Protein detail
CML2
Chemerin-like receptor 2 (Chemerin chemokine-like receptor 2) (Chemokine-like receptor 2) (G-protein coupled receptor 1)
Entry name CML2 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Chemerin-like receptor 2 (Chemerin chemokine-like receptor 2) (Chemokine-like receptor 2) (G-protein coupled receptor 1)
Protein Class (3)
G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins
Protein Function (2)
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
42..62; Helical; Name=1; 74..94; Helical; Name=2; 113..133; Helical; Name=3; 155..175; Helical; Name=4; 211..231; Helical; Name=5; 248..268; Helical; Name=6; 287..307; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
GPR1
Gene Description
Chemerin chemokine-like receptor 2
Chromosome
2
Position
206175316-206218047
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization3
Tissue SpecifictestisCell SpecificEarly spermatidsSingle-Nuclei Brain Specificependymal cell
Function & Pathway5
Protein Function (2)
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (4)
Molecular Function (5)
Biological Process (3)
Mediation Categories (2)
Metabolism mediationReceptor-signaling mediation
Relations & Evidence46
Ligand-Receptor Signaling (45)
45 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | No | No |
| receptor | receptor | ICELLNET | No | Yes | No | No | No |
| receptor | receptor | CellChatDB | No | Yes | No | No | No |
| receptor | receptor | CellTalkDB | No | Yes | No | No | No |
| receptor | receptor | Surfaceome | No | Yes | No | No | No |
| receptor | receptor | Ramilowski2015 | No | Yes | No | No | No |
| receptor | receptor | Guide2Pharma | No | Yes | No | No | No |
| gpcr | receptor | DGIdb | No | Yes | No | No | No |
| receptor | receptor | LRdb | No | Yes | No | No | No |
| gpcr | receptor | Almen2009 | No | Yes | No | No | No |
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Sequence, Structure & Domains9
Sequences
Length
355
Mass
41,431
Sequence
MEDLEETLFEEFENYSYDLDYYSLESDLEEKVQLGVVHWVSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARFRSSVAEILKYTLWEVSCSGTVSEQLRNSETKNLCLLETAQ
3D Structural Models
Turn
142..146; 235..237; 268..274
Helix
36..64; 72..88; 90..98; 108..140; 151..175; 199..214; 216..234; 242..267; 280..303; 309..324
Beta Strand
25..29; 176..181; 184..189; 196..198; 305..308
3D Structure
Electron microscopy (3)
Domain & Motif Annotations
Protein Families
Chemokine-like receptor (CMKLR) family
Sequence Similarities
Belongs to the chemokine-like receptor (CMKLR) family.
Clinical Relevance1
Antibody
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 32384937 | Alzheimer's disease progression characterized by alterations in the molecular profiles and biogenesis of brain extracellular vesicles. | No abstract available |