Protein detail
CML2
Chemerin-like receptor 2 (Chemerin chemokine-like receptor 2) (Chemokine-like receptor 2) (G-protein coupled receptor 1)
Protein symbol CML2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Chemerin-like receptor 2 (Chemerin chemokine-like receptor 2) (Chemokine-like receptor 2) (G-protein coupled receptor 1)
Protein Class
G-protein coupled receptorsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
42..62; Helical; Name=1; 74..94; Helical; Name=2; 113..133; Helical; Name=3; 155..175; Helical; Name=4; 211..231; Helical; Name=5; 248..268; Helical; Name=6; 287..307; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
GPR1
Gene Description
Chemerin chemokine-like receptor 2
Chromosome
2
Position
206175316-206218047
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecifictestisCell SpecificEarly spermatidsSingle-Nuclei Brain Specificependymal cell
Function & Pathway
Protein Function
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Metabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
45 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| rhodopsin | receptor | Almen2009 | No | Yes | No | No | No |
| gpcr | receptor | UniProt_keyword | No | Yes | No | No | No |
| rhodopsin | receptor | Surfaceome | No | Yes | No | No | No |
| gpcr | receptor | Surfaceome | No | Yes | No | No | No |
| class_a_rhodopsin | receptor | GPCRdb | No | Yes | No | No | No |
| class_a_rhodopsin_protein | receptor | GPCRdb | No | Yes | No | No | No |
| class_a_rhodopsin_protein_chemerin_receptor | receptor | GPCRdb | No | Yes | No | No | No |
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
355
Mass
41,431
Sequence
MEDLEETLFEEFENYSYDLDYYSLESDLEEKVQLGVVHWVSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARFRSSVAEILKYTLWEVSCSGTVSEQLRNSETKNLCLLETAQ
3D Structural Models
Turn
142..146; 235..237; 268..274
Helix
36..64; 72..88; 90..98; 108..140; 151..175; 199..214; 216..234; 242..267; 280..303; 309..324
Beta Strand
25..29; 176..181; 184..189; 196..198; 305..308
3D Structure
Electron microscopy (3)
Domain & Motif Annotations
Protein Families
Chemokine-like receptor (CMKLR) family
Sequence Similarities
Belongs to the chemokine-like receptor (CMKLR) family.
Clinical Relevance
Antibody