Protein detail
KC1D
Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
Entry name KC1D | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 2 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
Protein Class (6)
Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function (7)
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
- Kinases:CK1 Ser/Thr protein kinases
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
CKIDCKIdeltaHCKID
Gene Description
Casein kinase 1 delta
Chromosome
17
Position
82239023-82273700
Supporting publications (n)
2
EVMP confidence score
0.50
Function & Pathway7
Protein Function (7)
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
- Kinases:CK1 Ser/Thr protein kinases
Cellular Component (12)
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005794 Golgi apparatus
- GO:0005813 centrosome
- GO:0005819 spindle
- GO:0005829 cytosol
- GO:0005876 spindle microtubule
- GO:0005886 plasma membrane
- GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
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Molecular Function (8)
Biological Process (3)
KEGG (4)
Reactome (24)
- R-hsa-5620912 anchoring of the basal body to the plasma membrane
- R-hsa-446203 asparagine n linked glycosylation
- R-hsa-8854518 aurka activation by tpx2
- R-hsa-1640170 cell cycle
- R-hsa-69278 cell cycle mitotic
- R-hsa-5617833 cilium assembly
- R-hsa-9909396 circadian clock
- R-hsa-204005 copii mediated vesicle transport
- R-hsa-199977 er to golgi anterograde transport
- R-hsa-199991 membrane trafficking
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Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence72
Enzyme-Mediated Modification (7)
7 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CSNK1D | PRKCA | P17252 | T | 176 | phosphorylation | PhosphoSite | |
| CSNK1D | PRKCA | P17252 | T | 174 | phosphorylation | PhosphoSite | |
| CSNK1D | PRKCA | P17252 | S | 181 | phosphorylation | PhosphoSite | |
| CSNK1D | PRKCA | P17252 | S | 53 | phosphorylation | PhosphoSite | |
| CSNK1D | PRKCA | P17252 | S | 298 | phosphorylation | PhosphoSite | |
| CSNK1D | PRKCA | P17252 | T | 161 | phosphorylation | PhosphoSite | |
| CSNK1D | PRKCA | P17252 | S | 191 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling (9)
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network (47)
47 records.
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Protein Complex Composition (8)
8 records.
Sequence, Structure & Domains14
Sequences
Length
415
Mass
47,330
Sequence
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48730-1; Sequence=Displayed; Name=2; IsoId=P48730-2; Sequence=VSP_010253
Alternative Sequence
400..415; IPGRVASSGLQSVVHR -> NSIPFEHHGK (in isoform 2)
3D Structural Models
Turn
6..8; 29..32; 96..98; 159..161; 212..215; 241..243
Helix
49..59; 89..95; 102..121; 131..133; 139..141; 177..179; 182..185; 192..208; 221..233; 237..240; 247..257; 266..279; 280..283; 289..292
Beta Strand
3..5; 9..18; 21..28; 33..41; 44..46; 68..74; 77..83; 134..136; 145..147; 154..157; 217..219
3D Structure
X-ray crystallography (46)
Domain & Motif Annotations
Compositional Bias
301..315; Basic and acidic residues; 347..358; Polar residues; 380..400; Polar residues
Domain (FT)
9..277; Protein kinase
Region
278..364; Centrosomal localization signal (CLS); 301..415; Disordered; 317..342; Autoinhibitory
Protein Families (3)
- Protein kinase superfamily
- CK1 Ser/Thr protein kinase family
- Casein kinase I subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Clinical Relevance8
Disease Involvement
Disease variant
Related Diseases (2)
Biomarker
Preclinical
Drugs (22)
Interaction Protein (11)
ENSG00000107816ENSG00000112578ENSG00000113712ENSG00000132326ENSG00000135679ENSG00000157657ENSG00000161202ENSG00000165219ENSG00000171444ENSG00000189269ENSG00000213923
Interaction Count
11
Interaction Dataset (3)
intact_biogridbiogrid_opencellintact_biogrid_opencell
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 14602237 | Exosomes bearing HLA-G are released by melanoma cells. | Thus, the presence of tolerogenic HLA-G molecules on melanoma-derived exosomes may provide a novel way for tumors to modulate host's immune response. Besides the expression of well-described proteins such as Lamp-2, notably, these melanoma-derived exosomes bore HLA-G1. In addition, exosomes harboring HLA-G1 were secreted by the HLA-G-negative M8 melanoma cells transfected with the HLA-G1 cDNA. |
| 38627767 | Exosomes biogenesis was increased in metformin-treated human ovary cancer cells; possibly to mediate resistance. | After treatment with metformin, exosomes were isolated from cells and quantified by acetylcholinesterase (AChE) assay, Dynamic Light Scattering (DLS), and their markers. In vitro scratch assay showed that the cell migration rate of metformin-treated cells was decreased (P < 0.05), whereas AChE activity of exosomes from metformin-treated cells was increased (P < 0.05). |