EV MemProt Atlas

Basic Information11

Protein Names

Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)

Protein Class (6)

Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function (7)

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes
Kinases:CK1 Ser/Thr protein kinases

Ensembl

ENSG00000141551

Entrez Gene Symbol

CSNK1D

Gene Synonym (3)

CKIDCKIdeltaHCKID

Gene Description

Casein kinase 1 delta

Chromosome

17

Position

82239023-82273700

Supporting publications (n)

2

EVMP confidence score

0.50

Function & Pathway7

Protein Function (7)

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes
Kinases:CK1 Ser/Thr protein kinases

Cellular Component (12)

Page 1 of 2

Molecular Function (8)

Biological Process (3)

KEGG (4)

Reactome (24)

Page 1 of 3

Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence72

Enzyme-Mediated Modification (7)

7 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
CSNK1D	PRKCA	P17252	T	176	phosphorylation	PhosphoSite
CSNK1D	PRKCA	P17252	T	174	phosphorylation	PhosphoSite
CSNK1D	PRKCA	P17252	S	181	phosphorylation	PhosphoSite
CSNK1D	PRKCA	P17252	S	53	phosphorylation	PhosphoSite
CSNK1D	PRKCA	P17252	S	298	phosphorylation	PhosphoSite
CSNK1D	PRKCA	P17252	T	161	phosphorylation	PhosphoSite
CSNK1D	PRKCA	P17252	S	191	phosphorylation	PhosphoSite

Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network (47)

47 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KC1D	P48730	MDM2	Q00987	Yes	No	Yes	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperELMHINTKEAphosphoELM_KEAIntActSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:15703839 PhosphoSite:26294215 HINT:16870621 PhosphoSite:11850850 PhosphoSite:19008219 ProtMapper:20708156 PhosphoSite:28049764 ProtMapper:12167711 PhosphoSite:15688025 HINT:20708156 PhosphoSite:15024078 SIGNOR:20708156 ELM:20708156 PhosphoSite:33618712 PhosphoSite:19630168 KEA:15610030 IntAct:20708156 PhosphoSite:27617579 PhosphoSite:20708156 KEA:16055726 SIGNOR:12167711
KC1D	P48730	P53	P04637	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperHINTPhosphoSite_KEALit-BM-17NCI-PID_ProtMapperHPRDWangPhosphoSite_ProtMapperNetworKIN_KEAphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperPhosphoSiteSPIKE_LC	KEA:10606744 KEA:10747897 Lit-BM-17:16870621 KEA:11551930 HINT:16870621 SIGNOR:10606744 Lit-BM-17:17101137 HINT:17101137 KEA:10673501 ProtMapper:10734067 SIGNOR:10734067 KEA:10951572 Lit-BM-17:18246126 KEA:11709713 Lit-BM-17:25241761 HPRD:9349507 ProtMapper:10606744 SPIKE_LC:16713569 PhosphoSite:19345189 KEA:17570479 KEA:11883897 HPRD:10606744 PhosphoSite:10930428
KC1D	P48730	LEF1	Q9UJU2	Yes	No	Yes	SIGNORACSN	ACSN:15747065 ACSN:15327769 SIGNOR:15747065
KC1D	P48730	PER1	O15534	Yes	No	Yes	SIGNORPhosphoPointHPRDHINTBioGRIDSPIKE_LC	SIGNOR:11865049 SPIKE_LC:16189514 HPRD:11165242 HINT:32707033 HINT:33961781 BioGRID:11165242 SIGNOR:11165242
KC1D	P48730	YAP1	P46937	Yes	No	Yes	PhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapper	SIGNOR:24715453 ProtMapper:23431053 SIGNOR:23431053 ProtMapper:24715453
KC1D	P48730	CDK5	Q00535	Yes	Yes	No	WangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper	ProtMapper:10500146 SIGNOR:10500146 HPRD:10500146 KEA:10500146
FA83A	Q86UY5	KC1D	P48730	Yes	Yes	No	SIGNOR	SIGNOR:29789297
KC1D	P48730	TAU	P10636	Yes	No	Yes	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperHINTKEASIGNOR_ProtMapperNetworKIN_KEA	HINT:17101137 HINT:14761950 HINT:19014373 SIGNOR:14761950 ProtMapper:14761950 HINT:16618118 KEA:17570479
KC1D	P48730	ZN322	Q6U7Q0	Yes	No	Yes	PhosphoSite_norefSIGNORiPTMnetProtMapperSIGNOR_ProtMapperPhosphoSite_ProtMapper	ProtMapper:28581525 SIGNOR:28581525
KC1D	P48730	TOP2B	Q02880	Yes	No	Yes	PhosphoSite_norefSIGNOR	SIGNOR:32015321

Page 2 of 5Previous Next

Protein Complex Composition (8)

8 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster465	CSNK1A1 CSNK1A1L CSNK1D CSNK1E	P48729 P48730 P49674 Q8N752	1:1:1:1	Compleat	Compleat:HC2234	22036573
HT_SC_Cluster5	AATF BMS1 BYSL CSNK1A1 CSNK1A1L CSNK1D CSNK1E DCAF13 DDX18 DHX15 DHX37 DIMT1 DQX1 DRG1 EIF2A ELAVL1 EMG1 FBL FBLL1 HEATR1 IMP3 KRI1 KRR1 LARP1 LARP1B LTV1 MPHOSPH10 MYEF2 NAT10 NOB1 NOC4L NOL10 NOL6 NOP14 NOP56 NOP58 PNO1 PWP2 PYM1 RACK1 RIOK2 RPS10 RPS11 RPS13 RPS15A RPS17 RPS18 RPS24 RPS28 RPS4X RPS4Y1 RPS4Y2 RPS7 RPS8 RPS9 RRP12 RSL1D1 SRSF2 TFB1M TOP2A TOP2B TSR1 UTP20 UTP4 UTP6 WDR3 WDR31 WDR46	A6NHQ2 O00566 O00567 O15213 O43143 O75691 O76021 P08708 P11388 P22087 P22090 P46781 P46783 P48729 P48730 P49674 P62081 P62241 P62244 P62269 P62277 P62280 P62701 P62847 P62857 P63244 P78316 Q01130 Q02880 Q13601 Q13895 Q14692 Q15269 Q15717 Q2NL82 Q5JTH9 Q659C4 Q6PKG0 Q8IY37 Q8N752 Q8N9T8 Q8NA23 Q8TD47 Q8TE96 Q8WVM0 Q92979 Q969X6 Q96GA3 Q9BRP8 Q9BSC4 Q9BVI4 Q9BVS4 Q9BY44 Q9H0A0 Q9H583 Q9H6R4 Q9NRX1 Q9NV06 Q9NV31 Q9NVP1 Q9NY61 Q9NYH9 Q9P2K5 Q9ULX3 Q9UNQ2 Q9UNX4 Q9Y295 Q9Y2X3	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC1682
	CSNK1D IGF2BP3 LAPTM4A USP16	O00425 P48730 Q15012 Q9Y5T5	0:0:0:0	Havugimana2012	Havugimana2012:C_391
	CSNK1D PER2	O15055 P48730	2:2	PDB	PDB:8d7mPDB:8d7nPDB:8d7o
	CSNK1D CSNK1E FAM110B PER2 RPS4Y2	O15055 P48730 P49674 Q8TC76 Q8TD47	0:0:0:0:0	hu.MAP2
	CSNK1D	P48730	4	PDB	PDB:7qr9PDB:6hmrPDB:6pxnPDB:5oktPDB:3uytPDB:5mqvPDB:6gzmPDB:6f1wPDB:6rchPDB:7p7fPDB:4tw9PDB:7nzyPDB:9b3sPDB:8izcPDB:3uzpPDB:4hgtPDB:3uysPDB:4twcPDB:6pxpPDB:6hmpPDB:4kbkPDB:4kbaPDB:8vxfPDB:5w4wPDB:7qrbPDB:8vxdPDB:7p7hPDB:7qraPDB:4hnfPDB:4kbcPDB:4tn6PDB:7p7gPDB:6pxoPDB:6f26PDB:4kb8
	CSNK1D CSNK1E	P48730 P49674	0:0	hu.MAP2
	CSNK1D TP63	P48730 Q9H3D4	2:1	PDB	PDB:6ru8PDB:6ru6PDB:6ru7

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	2	38113368 30875722

Sequence, Structure & Domains14

Sequences

Length

415

Mass

47,330

Sequence

MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48730-1; Sequence=Displayed; Name=2; IsoId=P48730-2; Sequence=VSP_010253

Alternative Sequence

400..415; IPGRVASSGLQSVVHR -> NSIPFEHHGK (in isoform 2)

3D Structural Models

Turn

6..8; 29..32; 96..98; 159..161; 212..215; 241..243

Helix

49..59; 89..95; 102..121; 131..133; 139..141; 177..179; 182..185; 192..208; 221..233; 237..240; 247..257; 266..279; 280..283; 289..292

Beta Strand

3..5; 9..18; 21..28; 33..41; 44..46; 68..74; 77..83; 134..136; 145..147; 154..157; 217..219

3D Structure

X-ray crystallography (46)

Domain & Motif Annotations

Compositional Bias

301..315; Basic and acidic residues; 347..358; Polar residues; 380..400; Polar residues

Domain (FT)

9..277; Protein kinase

Region

278..364; Centrosomal localization signal (CLS); 301..415; Disordered; 317..342; Autoinhibitory

Protein Families (3)

Protein kinase superfamily
CK1 Ser/Thr protein kinase family
Casein kinase I subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

Clinical Relevance8

Disease Involvement

Disease variant

Related Diseases (2)

Mature B-cell leukaemia Pancreatic cancer

Biomarker

Preclinical

Antibody (3)

CAB015410 HPA070888 HPA072593

Interaction Protein (11)

ENSG00000107816ENSG00000112578ENSG00000113712ENSG00000132326ENSG00000135679ENSG00000157657ENSG00000161202ENSG00000165219ENSG00000171444ENSG00000189269ENSG00000213923

Interaction Count

11

Interaction Dataset (3)

intact_biogridbiogrid_opencellintact_biogrid_opencell

Supporting Publications2

PMID	Title	Abstract
14602237	Exosomes bearing HLA-G are released by melanoma cells.	Thus, the presence of tolerogenic HLA-G molecules on melanoma-derived exosomes may provide a novel way for tumors to modulate host's immune response. Besides the expression of well-described proteins such as Lamp-2, notably, these melanoma-derived exosomes bore HLA-G1. In addition, exosomes harboring HLA-G1 were secreted by the HLA-G-negative M8 melanoma cells transfected with the HLA-G1 cDNA.
38627767	Exosomes biogenesis was increased in metformin-treated human ovary cancer cells; possibly to mediate resistance.	After treatment with metformin, exosomes were isolated from cells and quantified by acetylcholinesterase (AChE) assay, Dynamic Light Scattering (DLS), and their markers. In vitro scratch assay showed that the cell migration rate of metformin-treated cells was decreased (P < 0.05), whereas AChE activity of exosomes from metformin-treated cells was increased (P < 0.05).

Entry name KC1D	UniProt ID P48730	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count	Protein classification Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteins

KC1D