Protein detail
KC1D
Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
Protein symbol KC1D | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count | Protein classification Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
Protein Class
Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteins
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
- Kinases:CK1 Ser/Thr protein kinases
Ensembl
Entrez Gene Symbol
Gene Synonym
CKIDCKIdeltaHCKID
Gene Description
Casein kinase 1 delta
Chromosome
17
Position
82239023-82273700
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
- Kinases:CK1 Ser/Thr protein kinases
Cellular Component
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005737 cytoplasm
- GO:0005794 Golgi apparatus
- GO:0005813 centrosome
- GO:0005819 spindle
- GO:0005829 cytosol
- GO:0005876 spindle microtubule
- GO:0005886 plasma membrane
- GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
- GO:0036064 ciliary basal body
- GO:0048471 perinuclear region of cytoplasm
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-5620912 anchoring of the basal body to the plasma membrane
- R-hsa-446203 asparagine n linked glycosylation
- R-hsa-8854518 aurka activation by tpx2
- R-hsa-1640170 cell cycle
- R-hsa-69278 cell cycle mitotic
- R-hsa-5617833 cilium assembly
- R-hsa-9909396 circadian clock
- R-hsa-204005 copii mediated vesicle transport
- R-hsa-199977 er to golgi anterograde transport
- R-hsa-199991 membrane trafficking
- R-hsa-8953854 metabolism of rna
- R-hsa-453274 mitotic g2 g2 m phases
- R-hsa-68877 mitotic prometaphase
- R-hsa-68886 m phase
- R-hsa-1852241 organelle biogenesis and maintenance
- R-hsa-9931530 phosphorylation and nuclear translocation of the cry per kinase complex
- R-hsa-597592 post translational protein modification
- R-hsa-380270 recruitment of mitotic centrosome proteins and complexes
- R-hsa-380320 recruitment of numa to mitotic centrosomes
- R-hsa-2565942 regulation of plk1 activity at g2 m transition
- R-hsa-72312 rrna processing
- R-hsa-9931521 the cry per kinase complex represses transactivation by the bmal clock arntl clock complex
- R-hsa-948021 transport to the golgi and subsequent modification
- R-hsa-5653656 vesicle mediated transport
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
7 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CSNK1D | PRKCA | P17252 | T | 176 | phosphorylation | PhosphoSite | |
| CSNK1D | PRKCA | P17252 | T | 174 | phosphorylation | PhosphoSite | |
| CSNK1D | PRKCA | P17252 | S | 181 | phosphorylation | PhosphoSite | |
| CSNK1D | PRKCA | P17252 | S | 53 | phosphorylation | PhosphoSite | |
| CSNK1D | PRKCA | P17252 | S | 298 | phosphorylation | PhosphoSite | |
| CSNK1D | PRKCA | P17252 | T | 161 | phosphorylation | PhosphoSite | |
| CSNK1D | PRKCA | P17252 | S | 191 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| receptor | receptor | scConnect | No | Yes | No | No | No |
Regulatory Interaction Network
47 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| KC1D | P48730 | WEE1 | P30291 | Yes | No | Yes | iPTMnetPhosphoSite_norefSIGNORProtMapperPhosphoSite_ProtMapper | SIGNOR:24817118 |
| KC1D | P48730 | CADH1 | P12830 | Yes | No | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperKEAphosphoELM_KEAphosphoELMPhosphoSitePhosphoSite_ProtMapper | SIGNOR:17353278PhosphoSite:17353278KEA:17353278phosphoELM:17353278PhosphoSite:22770219 |
| KC1D | P48730 | PRPC | P02810 | Yes | Yes | No | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | ProtMapper:10684652SIGNOR:10684652 |
| KC1D | P48730 | UHRF1 | Q96T88 | Yes | Yes | No | iPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:23297342PhosphoSite:23297342ProtMapper:23297342 |
| KC1D | P48730 | DCK | P27707 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperPhosphoSite_ProtMapper | SIGNOR:20637175 |
| KC1D | P48730 | HIF1A | Q16665 | Yes | No | Yes | PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:20699359ELM:20699359ProtMapper:20699359PhosphoSite:20699359 |
| FA83H | Q6ZRV2 | KC1D | P48730 | Yes | Yes | No | HINTSIGNOR | SIGNOR:29789297HINT:29789297HINT:33961781HINT:32707033 |
| KC1D | P48730 | WWTR1 | Q9GZV5 | Yes | No | Yes | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | SIGNOR:24715453ProtMapper:24715453 |
| KC1D | P48730 | SMCA4 | P51532 | Yes | No | Yes | PhosphoSite_norefSIGNORProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:30177679PhosphoSite:30177679 |
| FA83E | Q2M2I3 | KC1D | P48730 | Yes | Yes | No | SIGNOR | SIGNOR:29789297 |
Protein Complex Composition
8 records.
Sequence, Structure & Domains
Sequences
Length
415
Mass
47,330
Sequence
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48730-1; Sequence=Displayed; Name=2; IsoId=P48730-2; Sequence=VSP_010253
Alternative Sequence
400..415; IPGRVASSGLQSVVHR -> NSIPFEHHGK (in isoform 2)
3D Structural Models
Turn
6..8; 29..32; 96..98; 159..161; 212..215; 241..243
Helix
49..59; 89..95; 102..121; 131..133; 139..141; 177..179; 182..185; 192..208; 221..233; 237..240; 247..257; 266..279; 280..283; 289..292
Beta Strand
3..5; 9..18; 21..28; 33..41; 44..46; 68..74; 77..83; 134..136; 145..147; 154..157; 217..219
3D Structure
X-ray crystallography (46)
Domain & Motif Annotations
Compositional Bias
301..315; Basic and acidic residues; 347..358; Polar residues; 380..400; Polar residues
Domain (FT)
9..277; Protein kinase
Region
278..364; Centrosomal localization signal (CLS); 301..415; Disordered; 317..342; Autoinhibitory
Protein Families
- Protein kinase superfamily
- CK1 Ser/Thr protein kinase family
- Casein kinase I subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.
Clinical Relevance
Disease Involvement
Disease variant
Related Diseases
Biomarker
Preclinical
Drugs
Interaction Protein
ENSG00000107816ENSG00000112578ENSG00000113712ENSG00000132326ENSG00000135679ENSG00000157657ENSG00000161202ENSG00000165219ENSG00000171444ENSG00000189269ENSG00000213923
Interaction Count
11
Interaction Dataset
intact_biogridbiogrid_opencellintact_biogrid_opencell