Protein detail

KC1D

Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)

Protein symbol KC1D	UniProt ID P48730	EVMP score 0.50
Frequency 2	Transmembrane count	Protein classification Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)

Protein Class

Disease related genesEnzymesHuman disease related genesPlasma proteinsPotential drug targetsPredicted intracellular proteins

Protein Function

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes
Kinases:CK1 Ser/Thr protein kinases

Ensembl

ENSG00000141551

Entrez Gene Symbol

CSNK1D

Gene Synonym

CKIDCKIdeltaHCKID

Gene Description

Casein kinase 1 delta

Chromosome

Position

82239023-82273700

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Protein Function

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes
Kinases:CK1 Ser/Thr protein kinases

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

7 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database
CSNK1D	PRKCA	P17252	T	176	phosphorylation	PhosphoSite
CSNK1D	PRKCA	P17252	T	174	phosphorylation	PhosphoSite
CSNK1D	PRKCA	P17252	S	181	phosphorylation	PhosphoSite
CSNK1D	PRKCA	P17252	S	53	phosphorylation	PhosphoSite
CSNK1D	PRKCA	P17252	S	298	phosphorylation	PhosphoSite
CSNK1D	PRKCA	P17252	T	161	phosphorylation	PhosphoSite
CSNK1D	PRKCA	P17252	S	191	phosphorylation	PhosphoSite

Ligand-Receptor Signaling

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network

47 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
KC1D	P48730	KI3L1	P43629	Yes	Yes	No	PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:17911614 PhosphoSite:17911614 SIGNOR:17911614
KC1D	P48730	BACE1	P56817	Yes	No	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phosPhosphoSite_ProtMapper	HPRD-phos:11278841 phosphoELM:11278841 KEA:11860271 ProtMapper:11278841 HPRD:11278841 SIGNOR:11278841 KEA:11278841
KC1D	P48730	NCOA3	Q9Y6Q9	Yes	Yes	No	PhosphoSite_MIMPMIMPiPTMnetSIGNORProtMapperELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ELM:19339517 ProtMapper:19339517 SIGNOR:19339517 PhosphoSite:19339517
KC1D	P48730	LZTS2	Q9BRK4	Yes	No	No	PhosphoSite_norefProtMapperHuRIPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:33420362
KC1D	P48730	EPAS1	Q99814	Yes	No	No	PhosphoSite_norefProtMapperELMPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:34285132 PhosphoSite:27686097 ELM:27686097
KC1D	P48730	TADBP	Q13148	Yes	No	No	PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:23922830
KC1D	P48730	CASL	Q14511	Yes	No	No	PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:29191835

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Protein Complex Composition

8 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster465	CSNK1A1 CSNK1A1L CSNK1D CSNK1E	P48729 P48730 P49674 Q8N752	1:1:1:1	Compleat	Compleat:HC2234	22036573
HT_SC_Cluster5	AATF BMS1 BYSL CSNK1A1 CSNK1A1L CSNK1D CSNK1E DCAF13 DDX18 DHX15 DHX37 DIMT1 DQX1 DRG1 EIF2A ELAVL1 EMG1 FBL FBLL1 HEATR1 IMP3 KRI1 KRR1 LARP1 LARP1B LTV1 MPHOSPH10 MYEF2 NAT10 NOB1 NOC4L NOL10 NOL6 NOP14 NOP56 NOP58 PNO1 PWP2 PYM1 RACK1 RIOK2 RPS10 RPS11 RPS13 RPS15A RPS17 RPS18 RPS24 RPS28 RPS4X RPS4Y1 RPS4Y2 RPS7 RPS8 RPS9 RRP12 RSL1D1 SRSF2 TFB1M TOP2A TOP2B TSR1 UTP20 UTP4 UTP6 WDR3 WDR31 WDR46	A6NHQ2 O00566 O00567 O15213 O43143 O75691 O76021 P08708 P11388 P22087 P22090 P46781 P46783 P48729 P48730 P49674 P62081 P62241 P62244 P62269 P62277 P62280 P62701 P62847 P62857 P63244 P78316 Q01130 Q02880 Q13601 Q13895 Q14692 Q15269 Q15717 Q2NL82 Q5JTH9 Q659C4 Q6PKG0 Q8IY37 Q8N752 Q8N9T8 Q8NA23 Q8TD47 Q8TE96 Q8WVM0 Q92979 Q969X6 Q96GA3 Q9BRP8 Q9BSC4 Q9BVI4 Q9BVS4 Q9BY44 Q9H0A0 Q9H583 Q9H6R4 Q9NRX1 Q9NV06 Q9NV31 Q9NVP1 Q9NY61 Q9NYH9 Q9P2K5 Q9ULX3 Q9UNQ2 Q9UNX4 Q9Y295 Q9Y2X3	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC1682
	CSNK1D IGF2BP3 LAPTM4A USP16	O00425 P48730 Q15012 Q9Y5T5	0:0:0:0	Havugimana2012	Havugimana2012:C_391
	CSNK1D PER2	O15055 P48730	2:2	PDB	PDB:8d7mPDB:8d7nPDB:8d7o
	CSNK1D CSNK1E FAM110B PER2 RPS4Y2	O15055 P48730 P49674 Q8TC76 Q8TD47	0:0:0:0:0	hu.MAP2
	CSNK1D	P48730	4	PDB	PDB:7qr9PDB:6hmrPDB:6pxnPDB:5oktPDB:3uytPDB:5mqvPDB:6gzmPDB:6f1wPDB:6rchPDB:7p7fPDB:4tw9PDB:7nzyPDB:9b3sPDB:8izcPDB:3uzpPDB:4hgtPDB:3uysPDB:4twcPDB:6pxpPDB:6hmpPDB:4kbkPDB:4kbaPDB:8vxfPDB:5w4wPDB:7qrbPDB:8vxdPDB:7p7hPDB:7qraPDB:4hnfPDB:4kbcPDB:4tn6PDB:7p7gPDB:6pxoPDB:6f26PDB:4kb8
	CSNK1D CSNK1E	P48730 P49674	0:0	hu.MAP2
	CSNK1D TP63	P48730 Q9H3D4	2:1	PDB	PDB:6ru8PDB:6ru6PDB:6ru7

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	2	38113368 30875722

Sequence, Structure & Domains

Sequences

Length

415

Mass

47,330

Sequence

MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P48730-1; Sequence=Displayed; Name=2; IsoId=P48730-2; Sequence=VSP_010253

Alternative Sequence

400..415; IPGRVASSGLQSVVHR -> NSIPFEHHGK (in isoform 2)

3D Structural Models

Turn

6..8; 29..32; 96..98; 159..161; 212..215; 241..243

Helix

49..59; 89..95; 102..121; 131..133; 139..141; 177..179; 182..185; 192..208; 221..233; 237..240; 247..257; 266..279; 280..283; 289..292

Beta Strand

3..5; 9..18; 21..28; 33..41; 44..46; 68..74; 77..83; 134..136; 145..147; 154..157; 217..219

3D Structure

X-ray crystallography (46)

Domain & Motif Annotations

Compositional Bias

301..315; Basic and acidic residues; 347..358; Polar residues; 380..400; Polar residues

Domain (FT)

9..277; Protein kinase

Region

278..364; Centrosomal localization signal (CLS); 301..415; Disordered; 317..342; Autoinhibitory

Protein Families

Protein kinase superfamily
CK1 Ser/Thr protein kinase family
Casein kinase I subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.

Clinical Relevance

Disease Involvement

Disease variant

Related Diseases

Mature B-cell leukaemia Pancreatic cancer

Biomarker

Preclinical

Antibody

CAB015410 HPA070888 HPA072593

Interaction Protein

ENSG00000107816ENSG00000112578ENSG00000113712ENSG00000132326ENSG00000135679ENSG00000157657ENSG00000161202ENSG00000165219ENSG00000171444ENSG00000189269ENSG00000213923

Interaction Count

Interaction Dataset

intact_biogridbiogrid_opencellintact_biogrid_opencell