Protein detail

UBE2A

Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)

Entry name UBE2A	UniProt ID P49459	EVMP confidence score 0.38
Supporting publications (n) 1	Transmembrane count	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information6

Protein Names

Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)

Protein Function (6)

Human disease related genes:Other diseases:Mental and behavioural disorders
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes

Ensembl

ENSG00000077721

Entrez Gene Symbol

UBE2A

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization4

Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway8

Protein Function (6)

Human disease related genes:Other diseases:Mental and behavioural disorders
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes

Cellular Component (6)

Molecular Function (6)

Biological Process (3)

KEGG

hsa04120 Ubiquitin mediated proteolysis

Reactome (7)

Canonical Pathways (3)

M5887 Naba basement membranes
M3008 Naba ecm glycoproteins
M5884 Naba core matrisome

Mediation Categories (3)

Fusion and delivery mediationImmune mediationMetabolism mediation

Relations & Evidence41

Enzyme-Mediated Modification (12)

12 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
UBE2A	CDK1	P06493	S	120	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:11953320 KEA:11953320 ProtMapper:11953320 HPRD:11953320 phosphoELM:11953320
UBE2A	CDK1	P06493	S	90	phosphorylation	HPRDKEA	HPRD:11953320 KEA:11953320
UBE2A	CDK1	P06493	S	45	phosphorylation	KEA	KEA:11953320
UBE2A	CDK2	P24941	S	120	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:11953320 KEA:11953320 ProtMapper:11953320 KEA:17570479 HPRD:11953320 phosphoELM:11953320
UBE2A	CDK2	P24941	S	90	phosphorylation	HPRDKEA	HPRD:11953320 KEA:11953320
UBE2A	CDK2	P24941	S	45	phosphorylation	KEA	KEA:11953320
UBE2A	CDK5	Q00535	S	120	phosphorylation	PhosphoNetworks
UBE2A	GSK3B	P49841	S	120	phosphorylation	PhosphoNetworksKEA	KEA:17570479
UBE2A	MAPK1	P28482	S	120	phosphorylation	PhosphoNetworks
UBE2A	MAPK8	P45983	S	120	phosphorylation	PhosphoNetworks

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Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (12)

12 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
	COMPLEX:A0AVT1_P62987	UBE2A	P49459	Yes	Yes	No	SIGNOR	SIGNOR:34199813
CDK2	P24941	UBE2A	P49459	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_ProtMapperHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phosNetworKIN_KEA	SIGNOR:11953320 HPRD-phos:11953320 KEA:11953320 ProtMapper:11953320 KEA:17570479 HPRD:11953320 phosphoELM:11953320

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Protein Complex Composition (11)

11 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	RAD18 UBE2A	P49459 Q9NS91	0:0	SPIKEhu.MAPhu.MAP2

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	4	38731868 33709510 38490958 33580572

Sequence, Structure & Domains12

Sequences

Length

152

Mass

17,315

Sequence

MSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIMVWNAVIFGPEGTPFEDGTFKLTIEFTEEYPNKPPTVRFVSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWRDC

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P49459-1; Sequence=Displayed; Name=2; IsoId=P49459-2; Sequence=VSP_043852; Name=3; IsoId=P49459-3; Sequence=VSP_043851

Alternative Sequence

1..75; Missing (in isoform 3); 51..80; Missing (in isoform 2)

3D Structural Models

Turn

47..50; 61..64

Helix

4..18; 90..93; 102..114; 124..132; 134..148

Beta Strand

24..28; 35..42; 52..58; 69..72; 85..87

3D Structure

Electron microscopy (1); X-ray crystallography (3)

Domain & Motif Annotations

Domain (FT)

4..150; UBC core

Protein Families

Ubiquitin-conjugating enzyme family

Sequence Similarities

Belongs to the ubiquitin-conjugating enzyme family.

Clinical Relevance3

Interaction Protein (3)

ENSG00000070950ENSG00000103549ENSG00000155827

Interaction Count

Interaction Dataset (2)

intact_biogridbiogrid_opencell

Supporting Publications1

PMID	Title	Abstract
39535266	Divergent Proteomic Profiles and Uptake Mechanisms of Exosomes Derived from Human Dental Pulp Stem Cells, Endothelial Cells, and Fibroblasts.	No abstract available