Protein detail
UBE2A
Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)
Protein symbol UBE2A | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)
Protein Function
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Disease related genes
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-983168 antigen processing ubiquitination proteasome degradation
- R-hsa-983169 class i mhc mediated antigen processing presentation
- R-hsa-8866654 e3 ubiquitin ligases ubiquitinate target proteins
- R-hsa-597592 post translational protein modification
- R-hsa-8852135 protein ubiquitination
- R-hsa-8866652 synthesis of active ubiquitin roles of e1 and e2 enzymes
Canonical Pathways
- M5887 Naba basement membranes
- M3008 Naba ecm glycoproteins
- M5884 Naba core matrisome
Mediation Categories
Fusion and delivery mediationImmune mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
12 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| UBE2A | CDK1 | P06493 | S | 120 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:11953320KEA:11953320ProtMapper:11953320HPRD:11953320phosphoELM:11953320 |
| UBE2A | CDK1 | P06493 | S | 90 | phosphorylation | HPRDKEA | HPRD:11953320KEA:11953320 |
| UBE2A | CDK1 | P06493 | S | 45 | phosphorylation | KEA | KEA:11953320 |
| UBE2A | CDK2 | P24941 | S | 120 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:11953320KEA:11953320ProtMapper:11953320KEA:17570479HPRD:11953320phosphoELM:11953320 |
| UBE2A | CDK2 | P24941 | S | 90 | phosphorylation | HPRDKEA | HPRD:11953320KEA:11953320 |
| UBE2A | CDK2 | P24941 | S | 45 | phosphorylation | KEA | KEA:11953320 |
| UBE2A | CDK5 | Q00535 | S | 120 | phosphorylation | PhosphoNetworks | |
| UBE2A | GSK3B | P49841 | S | 120 | phosphorylation | PhosphoNetworksKEA | KEA:17570479 |
| UBE2A | MAPK1 | P28482 | S | 120 | phosphorylation | PhosphoNetworks | |
| UBE2A | MAPK8 | P45983 | S | 120 | phosphorylation | PhosphoNetworks |
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Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
12 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:A0AVT1_P62987 | UBE2A | P49459 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| CDK2 | P24941 | UBE2A | P49459 | Yes | Yes | No | phosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_ProtMapperHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phosNetworKIN_KEA | SIGNOR:11953320HPRD-phos:11953320KEA:11953320ProtMapper:11953320KEA:17570479HPRD:11953320phosphoELM:11953320 |
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Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
152
Mass
17,315
Sequence
MSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIMVWNAVIFGPEGTPFEDGTFKLTIEFTEEYPNKPPTVRFVSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWRDC
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P49459-1; Sequence=Displayed; Name=2; IsoId=P49459-2; Sequence=VSP_043852; Name=3; IsoId=P49459-3; Sequence=VSP_043851
Alternative Sequence
1..75; Missing (in isoform 3); 51..80; Missing (in isoform 2)
3D Structural Models
Turn
47..50; 61..64
Helix
4..18; 90..93; 102..114; 124..132; 134..148
Beta Strand
24..28; 35..42; 52..58; 69..72; 85..87
3D Structure
Electron microscopy (1); X-ray crystallography (3)
Domain & Motif Annotations
Domain (FT)
4..150; UBC core
Protein Families
Ubiquitin-conjugating enzyme family
Sequence Similarities
Belongs to the ubiquitin-conjugating enzyme family.
Clinical Relevance
Interaction Protein
ENSG00000070950ENSG00000103549ENSG00000155827
Interaction Count
3
Interaction Dataset
intact_biogridbiogrid_opencell