Protein detail

UBE2A

Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)

Protein symbol UBE2A	UniProt ID P49459	EVMP score 0.38
Frequency 1	Transmembrane count	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A)

Protein Function

Human disease related genes:Other diseases:Mental and behavioural disorders
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes

Ensembl

ENSG00000077721

Entrez Gene Symbol

UBE2A

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue Specificchoroid plexusBrain Regional Specificchoroid plexusCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway

Protein Function

Human disease related genes:Other diseases:Mental and behavioural disorders
Predicted intracellular proteins
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Disease related genes

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04120 Ubiquitin mediated proteolysis

Reactome

Canonical Pathways

M5887 Naba basement membranes
M3008 Naba ecm glycoproteins
M5884 Naba core matrisome

Mediation Categories

Fusion and delivery mediationImmune mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

12 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
UBE2A	CDK9	P50750	S	120	phosphorylation	RLIMS-P_ProtMapperREACH_ProtMapperSparser_ProtMapperProtMapper	ProtMapper:22722497
UBE2A	MAPK14	Q16539	S	120	phosphorylation	KEA	KEA:17570479

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Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

12 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
	COMPLEX:A0AVT1_P62987	UBE2A	P49459	Yes	Yes	No	SIGNOR	SIGNOR:34199813
CDK2	P24941	UBE2A	P49459	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_ProtMapperHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phosNetworKIN_KEA	SIGNOR:11953320 HPRD-phos:11953320 KEA:11953320 ProtMapper:11953320 KEA:17570479 HPRD:11953320 phosphoELM:11953320

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Protein Complex Composition

11 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
RAD6A-KCMF1-UBR4 complex	KCMF1 UBE2A UBR4	P49459 Q5T4S7 Q9P0J7	0:0:0	CORUM	CORUM:6780	25582440
Ub:E2	UBB UBE2A	P0CG47 P49459	0:0	SIGNOR	SIGNOR:SIGNOR-C497
Ub:E2	UBC UBE2A	P0CG48 P49459	0:0	SIGNOR	SIGNOR:SIGNOR-C497
Ub:E2	RPS27A UBE2A	P49459 P62979	0:0	SIGNOR	SIGNOR:SIGNOR-C497
Ub:E2	UBA52 UBE2A	P49459 P62987	0:0	SIGNOR	SIGNOR:SIGNOR-C497
	POMP PSMA1 PSMA2 PSMA4 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 UBE2A UBR1	O14818 P20618 P25786 P25787 P25789 P28070 P28072 P28074 P49459 P49720 P49721 P60900 Q8IWV7 Q99436 Q9Y244	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9345
	POMP UBE2A UBE2V1 UGDH ULK4	O60701 P49459 Q13404 Q96C45 Q9Y244	0:0:0:0:0	Havugimana2012	Havugimana2012:C_489
	CSE1L TWF1 UBE2A UNC45A USP1 WDR5 ZBED1 ZWILCH	O94782 O96006 P49459 P55060 P61964 Q12792 Q9H3U1 Q9H900	0:0:0:0:0:0:0:0	Havugimana2012	Havugimana2012:C_551
	UBE2A UBR4	P49459 Q5T4S7	2:1	PDB	PDB:8btl
	RAD18 SLF1 SLF2 UBE2A	P49459 Q8IX21 Q9BQI6 Q9NS91	0:0:0:0	hu.MAP2

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	4	38731868 33709510 38490958 33580572

Sequence, Structure & Domains

Sequences

Length

152

Mass

17,315

Sequence

MSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIMVWNAVIFGPEGTPFEDGTFKLTIEFTEEYPNKPPTVRFVSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWRDC

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P49459-1; Sequence=Displayed; Name=2; IsoId=P49459-2; Sequence=VSP_043852; Name=3; IsoId=P49459-3; Sequence=VSP_043851

Alternative Sequence

1..75; Missing (in isoform 3); 51..80; Missing (in isoform 2)

3D Structural Models

Turn

47..50; 61..64

Helix

4..18; 90..93; 102..114; 124..132; 134..148

Beta Strand

24..28; 35..42; 52..58; 69..72; 85..87

3D Structure

Electron microscopy (1); X-ray crystallography (3)

Domain & Motif Annotations

Domain (FT)

4..150; UBC core

Protein Families

Ubiquitin-conjugating enzyme family

Sequence Similarities

Belongs to the ubiquitin-conjugating enzyme family.

Clinical Relevance

Interaction Protein

ENSG00000070950ENSG00000103549ENSG00000155827

Interaction Count

Interaction Dataset

intact_biogridbiogrid_opencell