Protein detail
CXCR3
C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183)
Protein symbol CXCR3 | UniProt ID | EVMP score 0.25 |
Frequency 3 | Transmembrane count 7 | Protein classification CD markersG-protein coupled receptorsPredicted membrane proteins |
Basic Information
Protein Names
C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183)
Protein Class
CD markersG-protein coupled receptorsPredicted membrane proteins
Protein Function
- G-protein coupled receptors:Chemokines and chemotactic factors receptors
- CD markers
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
54..80; Helical; Name=1; 90..110; Helical; Name=2; 126..147; Helical; Name=3; 170..189; Helical; Name=4; 213..233; Helical; Name=5; 256..277; Helical; Name=6; 299..321; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
CD183CKR-L2CMKAR3GPR9IP10-RMigR
Gene Description
C-X-C motif chemokine receptor 3
Chromosome
X
Position
71615916-71618511
Frequency
3
EVMP Score
0.25
Fluorescence & Localization
Function & Pathway
Protein Function
- G-protein coupled receptors:Chemokines and chemotactic factors receptors
- CD markers
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-380108 chemokine receptors bind chemokines
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-9942503 differentiation of naive cd t cells to t helper 1 cells th1 cells
- R-hsa-500792 gpcr ligand binding
- R-hsa-418594 g alpha i signalling events
- R-hsa-375276 peptide ligand binding receptors
- R-hsa-372790 signaling by gpcr
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
66 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | DGIdb | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
Regulatory Interaction Network
3 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
368
Mass
40,660
Sequence
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=CXCR3-A; IsoId=P49682-1; Sequence=Displayed; Name=2; Synonyms=CXCR3-B; IsoId=P49682-2; Sequence=VSP_015684; Name=3; Synonyms=CXCR3-alt; IsoId=P49682-3; Sequence=VSP_015685
Alternative Sequence
1..4; MVLE -> MELRKYGPGRLAGTVIGGAAQSKSQTKSDSITKEFLPGLYTAPSSPFPPSQ (in isoform 2); 210..368; VGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL -> GSSSGSGCGCCSCAWAAPTREGSRGSHRLPAGIHPGLRPQRPPTRACEAGIRAPLSPI (in isoform 3)
3D Structural Models
Turn
81..83; 196..199; 282..284; 319..321
Helix
61..80; 88..114; 122..154; 156..162; 169..183; 187..189; 209..244; 249..281; 290..318; 323..334
Beta Strand
190..193; 202..205
3D Structure
Electron microscopy (12)
Domain & Motif Annotations
Compositional Bias
357..368; Low complexity
Region
342..368; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Biomarker
Preclinical; Discontinued in Phase 1; Discontinued in Phase 2
Antibody