Protein detail
CXCR3
C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183)
Entry name CXCR3 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 3 | Transmembrane count 7 | Protein classification CD markersG-protein coupled receptorsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
C-X-C chemokine receptor type 3 (CXC-R3) (CXCR-3) (CKR-L2) (G protein-coupled receptor 9) (Interferon-inducible protein 10 receptor) (IP-10 receptor) (CD antigen CD183)
Protein Class (3)
CD markersG-protein coupled receptorsPredicted membrane proteins
Protein Function (3)
- G-protein coupled receptors:Chemokines and chemotactic factors receptors
- CD markers
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
54..80; Helical; Name=1; 90..110; Helical; Name=2; 126..147; Helical; Name=3; 170..189; Helical; Name=4; 213..233; Helical; Name=5; 256..277; Helical; Name=6; 299..321; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym (6)
CD183CKR-L2CMKAR3GPR9IP10-RMigR
Gene Description
C-X-C motif chemokine receptor 3
Chromosome
X
Position
71615916-71618511
Supporting publications (n)
3
EVMP confidence score
0.25
Function & Pathway7
Protein Function (3)
- G-protein coupled receptors:Chemokines and chemotactic factors receptors
- CD markers
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (4)
Molecular Function (8)
Biological Process (3)
KEGG (3)
Reactome (7)
- R-hsa-380108 chemokine receptors bind chemokines
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-9942503 differentiation of naive cd t cells to t helper 1 cells th1 cells
- R-hsa-500792 gpcr ligand binding
- R-hsa-418594 g alpha i signalling events
- R-hsa-375276 peptide ligand binding receptors
- R-hsa-372790 signaling by gpcr
Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence70
Ligand-Receptor Signaling (66)
66 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
Regulatory Interaction Network (3)
3 records.
Sequence, Structure & Domains13
Sequences
Length
368
Mass
40,660
Sequence
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=CXCR3-A; IsoId=P49682-1; Sequence=Displayed; Name=2; Synonyms=CXCR3-B; IsoId=P49682-2; Sequence=VSP_015684; Name=3; Synonyms=CXCR3-alt; IsoId=P49682-3; Sequence=VSP_015685
Alternative Sequence
1..4; MVLE -> MELRKYGPGRLAGTVIGGAAQSKSQTKSDSITKEFLPGLYTAPSSPFPPSQ (in isoform 2); 210..368; VGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL -> GSSSGSGCGCCSCAWAAPTREGSRGSHRLPAGIHPGLRPQRPPTRACEAGIRAPLSPI (in isoform 3)
3D Structural Models
Turn
81..83; 196..199; 282..284; 319..321
Helix
61..80; 88..114; 122..154; 156..162; 169..183; 187..189; 209..244; 249..281; 290..318; 323..334
Beta Strand
190..193; 202..205
3D Structure
Electron microscopy (12)
Domain & Motif Annotations
Compositional Bias
357..368; Low complexity
Region
342..368; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance4
Related Diseases (4)
Biomarker
Preclinical; Discontinued in Phase 1; Discontinued in Phase 2
Antibody
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 37686366 | Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics. | No abstract available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No abstract available |
| 38698420 | Single-sEV profiling identifies the TACSTD2 + sEV subpopulation as a factor of tumor susceptibility in the elderly. | No abstract available |