Protein detail

EI2BB

Translation initiation factor eIF2B subunit beta (S20I15) (S20III15) (eIF2B GDP-GTP exchange factor subunit beta)

Protein symbol EI2BB	UniProt ID P49770	EVMP score 0.50
Frequency 7	Transmembrane count	Protein classification Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteins

Basic Information

Protein Names

Translation initiation factor eIF2B subunit beta (S20I15) (S20III15) (eIF2B GDP-GTP exchange factor subunit beta)

Protein Class

Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteins

Protein Function

Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Predicted intracellular proteins

Ensembl

ENSG00000119718

Entrez Gene Symbol

EIF2B2

Gene Synonym

EIF-2BbetaEIF2BEIF2Bbeta

Gene Description

Eukaryotic translation initiation factor 2B subunit beta

Chromosome

Position

75002921-75012366

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificAdipocytes

Function & Pathway

Protein Function

Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa05168 Herpes simplex virus 1 infection

Reactome

Mediation Categories

Immune mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
EI2BB	P49770	IF2G	P41091	Yes	Yes	No	SIGNOR	SIGNOR:15054402
EI2BB	P49770	IF2B	P20042	Yes	Yes	No	SIGNOR	SIGNOR:15054402
EI2BB	P49770		COMPLEX:CHEBI:15996_CHEBI:16635_P05198_P20042_P41091	Yes	Yes	No	SIGNOR	SIGNOR:15054402
GSK3B	P49841	EI2BB	P49770	Yes	No	Yes	SIGNOR	SIGNOR:21798082
EI2BB	P49770	IF2A	P05198	Yes	Yes	No	HPRDHINTSIGNOR	HINT:31048492 HPRD:8887689 HINT:34876589 HINT:31048491 HINT:8887689 SIGNOR:15054402

Protein Complex Composition

18 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
EIF2B1-EIF2B2-EIF2B3-EIF2B4-EIF2B5 complex	EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5	P49770 Q13144 Q14232 Q9NR50 Q9UI10	2:2:2:2:2	CORUMComplexPortalCompleathu.MAP2PDB	PDB:7kmfintact:EBI-46451339PDB:6EZOPDB:7d46PDB:6CAJPDB:6ezoPDB:8tqzPDB:6cajCompleat:HC1542CORUM:7292PDB:7l7gPDB:7TRJPDB:7trjPDB:7l70	35416150 8506384 29599245 29599213 14755292 24532666
EIF2B2-EIF2B3-EIF2B4-EIF2B5 complex	EIF2B2 EIF2B3 EIF2B4 EIF2B5	P49770 Q13144 Q9NR50 Q9UI10	1:1:1:1	CORUMHavugimana2012hu.MAP2PDB	Havugimana2012:C_209CORUM:7291PDB:8tqo	24532666
HT_SC_Cluster31	CDC123 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3	O75794 P05198 P20042 P41091 P49770 Q13144 Q14232 Q9NR50 Q9UI10	1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC1360
eukaryotic translation initiation factor 2B complex	EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1	P05198 P49770 Q13144 Q14232 Q9NR50 Q9UI10	2:2:2:2:2:2	CompleatPDB	PDB:6o9zCompleat:HC2479PDB:7d45PDB:7d44	11323413
	AHCY CPS1 EIF1B EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 EIF5 PINX1 UBC	O60739 P05198 P0CG48 P20042 P23526 P31327 P41091 P49770 P55010 Q13144 Q14232 Q96BK5 Q9NR50 Q9UI10	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4765
	CPS1 EIF1B EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 EIF4G2 EIF5 UBC	O60739 P05198 P0CG48 P20042 P31327 P41091 P49770 P55010 P78344 Q13144 Q14232 Q9NR50 Q9UI10	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7076
	CPS1 CYLC2 EIF1B EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 EIF5 SLTM UBC	O60739 P05198 P0CG48 P20042 P31327 P41091 P49770 P55010 Q13144 Q14093 Q14232 Q9NR50 Q9NWH9 Q9UI10	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3674
	CPS1 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 EIF5 IST1 UBC XYLB	O75191 P05198 P0CG48 P20042 P31327 P41091 P49770 P53990 P55010 Q13144 Q14232 Q9NR50 Q9UI10	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4781
	CPS1 DNPEP EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 IST1 KIF4A UBC	O95239 P05198 P0CG48 P20042 P31327 P41091 P49770 P53990 Q13144 Q14232 Q9NR50 Q9UI10 Q9ULA0	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6108
	CPS1 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 GSK3A IST1 UBC UHMK1	P05198 P0CG48 P20042 P31327 P41091 P49770 P49840 P53990 Q13144 Q14232 Q8TAS1 Q9NR50 Q9UI10	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6368

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass spectrometry [LTQ-FT Ultra]Mass spectrometry	1	32384937

Sequence, Structure & Domains

Sequences

Length

351

Mass

38,990

Sequence

MPGSAAKGSELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIITDHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRVLKIIREEYGRLHGRSDESDQQESLHKLLTSGGLNEDFSFHYAQLQSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKEAARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL

3D Structural Models

Turn

156..158; 182..184; 279..281

Helix

9..24; 31..48; 54..71; 76..97; 109..114; 129..145; 147..152; 172..181; 200..209; 219..221; 222..225; 226..228; 251..260; 271..273; 291..293; 297..299; 301..304; 318..320; 333..335; 336..343; 346..348

Beta Strand

28..30; 164..169; 188..193; 195..197; 213..218; 230..234; 237..239; 241..243; 245..248; 265..268; 283..286; 305..308; 313..316; 323..326; 329..331

3D Structure

Electron microscopy (22)

Domain & Motif Annotations

Protein Families

EIF-2B alpha/beta/delta subunits family

Sequence Similarities

Belongs to the eIF-2B alpha/beta/delta subunits family.

Clinical Relevance

Disease Involvement

Disease variantLeukodystrophy

Antibody

HPA005841 CAB037105 HPA048028

Interaction Protein

ENSG00000070785ENSG00000100664ENSG00000111361ENSG00000115211ENSG00000145191

Interaction Count

Interaction Dataset

intact_biogrid_bioplexbiogrid_opencellintact_biogrid