Protein detail

EI2BB

Translation initiation factor eIF2B subunit beta (S20I15) (S20III15) (eIF2B GDP-GTP exchange factor subunit beta)

Entry name EI2BB	UniProt ID P49770	EVMP confidence score 0.50
Supporting publications (n) 7	Transmembrane count	Protein classification Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Translation initiation factor eIF2B subunit beta (S20I15) (S20III15) (eIF2B GDP-GTP exchange factor subunit beta)

Protein Class (4)

Disease related genesEssential proteinsHuman disease related genesPredicted intracellular proteins

Protein Function (4)

Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Predicted intracellular proteins

Ensembl

ENSG00000119718

Entrez Gene Symbol

EIF2B2

Gene Synonym (3)

EIF-2BbetaEIF2BEIF2Bbeta

Gene Description

Eukaryotic translation initiation factor 2B subunit beta

Chromosome

Position

75002921-75012366

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Cell SpecificAdipocytes

Function & Pathway7

Protein Function (4)

Human disease related genes:Nervous system diseases:Neurodegenerative diseases
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of lipid/glycolipid metabolism
Predicted intracellular proteins

Cellular Component (3)

Molecular Function (5)

Biological Process (3)

KEGG

hsa05168 Herpes simplex virus 1 infection

Reactome (3)

Mediation Categories (2)

Immune mediationMetabolism mediation

Relations & Evidence29

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (5)

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
EI2BB	P49770	IF2G	P41091	Yes	Yes	No	SIGNOR	SIGNOR:15054402
EI2BB	P49770	IF2B	P20042	Yes	Yes	No	SIGNOR	SIGNOR:15054402
EI2BB	P49770		COMPLEX:CHEBI:15996_CHEBI:16635_P05198_P20042_P41091	Yes	Yes	No	SIGNOR	SIGNOR:15054402
GSK3B	P49841	EI2BB	P49770	Yes	No	Yes	SIGNOR	SIGNOR:21798082
EI2BB	P49770	IF2A	P05198	Yes	Yes	No	HPRDHINTSIGNOR	HINT:31048492 HPRD:8887689 HINT:34876589 HINT:31048491 HINT:8887689 SIGNOR:15054402

Protein Complex Composition (18)

18 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CPS1 DDX24 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 IST1 MRPL4 UBC	P05198 P0CG48 P20042 P31327 P41091 P49770 P53990 Q13144 Q14232 Q9BYD3 Q9GZR7 Q9NR50 Q9UI10	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4966
CPS1 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3 EIF5 PUM1 UBC YWHAG	P05198 P0CG48 P20042 P31327 P41091 P49770 P55010 P61981 Q13144 Q14232 Q14671 Q9NR50 Q9UI10	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8103
EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S2 EIF2S3	P05198 P20042 P41091 P49770 Q13144 Q14232 Q9NR50 Q9UI10	1:1:1:2:2:2:2:2	PDB	PDB:6k72PDB:6k71PDB:7d43
EIF2B2 EIF2B3 EIF2B4 EIF2S1 EIF2S2 FOXRED1	P05198 P20042 P49770 Q96CU9 Q9NR50 Q9UI10	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4376
EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 EIF2S1 EIF2S3	P05198 P41091 P49770 Q13144 Q14232 Q9NR50 Q9UI10	2:2:2:2:2:2:2	PDB	PDB:6o81PDB:6o85
EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 HEATR3 SAAL1 SCMH1 ZSWIM6	P49770 Q13144 Q14232 Q7Z4Q2 Q96ER3 Q96GD3 Q9HCJ5 Q9NR50 Q9UI10	0:0:0:0:0:0:0:0:0	hu.MAP
EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5 HEATR3 SAAL1	P49770 Q13144 Q14232 Q7Z4Q2 Q96ER3 Q9NR50 Q9UI10	0:0:0:0:0:0:0	hu.MAP
ADI1 EIF2B1 EIF2B2 EIF2B3 EIF2B4 EIF2B5	P49770 Q13144 Q14232 Q9BV57 Q9NR50 Q9UI10	0:0:0:0:0:0	hu.MAP2

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass spectrometry [LTQ-FT Ultra]Mass spectrometry	1	32384937

Sequence, Structure & Domains9

Sequences

Length

351

Mass

38,990

Sequence

MPGSAAKGSELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIITDHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRVLKIIREEYGRLHGRSDESDQQESLHKLLTSGGLNEDFSFHYAQLQSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTIGFSRTVEAFLKEAARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVIIGTKTILANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFDYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL

3D Structural Models

Turn

156..158; 182..184; 279..281

Helix

9..24; 31..48; 54..71; 76..97; 109..114; 129..145; 147..152; 172..181; 200..209; 219..221; 222..225; 226..228; 251..260; 271..273; 291..293; 297..299; 301..304; 318..320; 333..335; 336..343; 346..348

Beta Strand

28..30; 164..169; 188..193; 195..197; 213..218; 230..234; 237..239; 241..243; 245..248; 265..268; 283..286; 305..308; 313..316; 323..326; 329..331

3D Structure

Electron microscopy (22)

Domain & Motif Annotations

Protein Families

EIF-2B alpha/beta/delta subunits family

Sequence Similarities

Belongs to the eIF-2B alpha/beta/delta subunits family.

Clinical Relevance5

Disease Involvement (2)

Disease variantLeukodystrophy

Antibody (3)

HPA005841 CAB037105 HPA048028

Interaction Protein (5)

ENSG00000070785ENSG00000100664ENSG00000111361ENSG00000115211ENSG00000145191

Interaction Count

Interaction Dataset (3)

intact_biogrid_bioplexbiogrid_opencellintact_biogrid

Supporting Publications7

PMID	Title	Abstract
27821849	Detailed Analysis of Protein Topology of Extracellular Vesicles-Evidence of Unconventional Membrane Protein Orientation.	No abstract available
31382537	An Insight into the Proteome of Uveal Melanoma-Derived Ectosomes Reveals the Presence of Potentially Useful Biomarkers.	No abstract available
34815502	The von Willebrand factor stamps plasmatic extracellular vesicles from glioblastoma patients.	No abstract available
35119778	Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis.	No abstract available
36394150	A large-scale targeted proteomics of plasma extracellular vesicles shows utility for prognosis prediction subtyping in colorectal cancer.	No abstract available
36736734	Extracellular vesicle proteomics and phosphoproteomics identify pathways for increased risk in patients hospitalized with COVID-19 and type 2 diabetes mellitus.	No abstract available
38716512	Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics.	No abstract available