Protein detail
HINT1
Adenosine 5'-monophosphoramidase HINT1 (EC 3.9.1.-) (Desumoylating isopeptidase HINT1) (EC 3.4.22.-) (Histidine triad nucleotide-binding protein 1) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1)
Protein symbol HINT1 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Adenosine 5'-monophosphoramidase HINT1 (EC 3.9.1.-) (Desumoylating isopeptidase HINT1) (EC 3.4.22.-) (Histidine triad nucleotide-binding protein 1) (Protein kinase C inhibitor 1) (Protein kinase C-interacting protein 1) (PKCI-1)
Protein Class
Disease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Disease related genes
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
HINTPKCI-1PRKCNH1
Gene Description
Histidine triad nucleotide binding protein 1
Chromosome
5
Position
131155383-131224468
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificcDCSingle-Nuclei Brain Specificleukocyte
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Reactome
- R-hsa-9856651 mitf m dependent gene expression
- R-hsa-9730414 mitf m regulated melanocyte development
- R-hsa-9824594 regulation of mitf m dependent genes involved in apoptosis
- R-hsa-9825892 regulation of mitf m dependent genes involved in cell cycle and proliferation
- R-hsa-9856649 transcriptional and post translational regulation of mitf m expression and activity
Mediation Categories
Receptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
15 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GPX4HINT1 | P36969P49773 | 0:0 | hu.MAP | |||
| HINT1 | P49773 | 2 | PDB | PDB:6j64PDB:5waaPDB:5ipcPDB:6n3vPDB:8pwkPDB:6g9zPDB:6n3xPDB:5i2ePDB:5i2fPDB:5km1PDB:8paiPDB:4eqhPDB:6n3wPDB:5km2PDB:1kpbPDB:6j5sPDB:5ipbPDB:6j65PDB:7q2uPDB:5ipePDB:5wa8PDB:8pa6PDB:6j53PDB:5km4PDB:6j5zPDB:8pa9PDB:1av5PDB:8wzdPDB:4zkvPDB:1kpaPDB:5ed6PDB:3tw2PDB:1kpePDB:5ipdPDB:8p8pPDB:8pafPDB:4eqePDB:5kmaPDB:5kmcPDB:9gyqPDB:5klyPDB:5emtPDB:5klzPDB:9gypPDB:5ed3PDB:4zklPDB:4eqgPDB:6j58PDB:6yqmPDB:6n3yPDB:1kpcPDB:5wa9PDB:5km0PDB:5kmbPDB:5o8iPDB:5km3 | ||
| HINT1ME3 | P49773Q16798 | 0:0 | hu.MAP | |||
| HDAC7HINT1TTF2 | P49773Q8WUI4Q9UNY4 | 0:0:0 | hu.MAP2 | |||
| DHX36HEBP1HINT1 | P49773Q9H2U1Q9NRV9 | 0:0:0 | Havugimana2012 | Havugimana2012:C_141 |
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 38037300 |
Sequence, Structure & Domains
Sequences
Length
126
Mass
13,802
Sequence
MADEIAKAQVARPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
3D Structural Models
Helix
18..23; 63..65; 68..70; 71..87; 101..104
Beta Strand
31..34; 36..42; 47..58; 94..100; 108..110; 113..119
3D Structure
X-ray crystallography (59)
Domain & Motif Annotations
Motif
110..114; Histidine triad motif
Domain (FT)
18..126; HIT
Protein Families
HINT family
Sequence Similarities
Belongs to the HINT family.