Protein detail

GDIB

Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2)

Entry name GDIB	UniProt ID P50395	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2)

Protein Class (2)

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000057608

Entrez Gene Symbol

GDI2

Gene Synonym

RABGDIB

Gene Description

GDP dissociation inhibitor 2

Chromosome

Position

5765223-5842132

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway5

Protein Function

Predicted intracellular proteins

Cellular Component (11)

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Molecular Function (5)

Reactome (6)

Mediation Categories (4)

Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence35

Enzyme-Mediated Modification (2)

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
GDI2	PAK1	Q13153	T	248	phosphorylation	PhosphoSite
GDI2	PAK1	Q13153	S	382	phosphorylation	PhosphoSite

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (1)

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PAK1	Q13153	GDIB	P50395	Yes	No	No	PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:33914026

Protein Complex Composition (24)

24 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
HT_SC_Cluster313	CHM CHML GDI1 GDI2 JAZF1	P24386 P26374 P31150 P50395 Q86VZ6	1:1:1:1:1	Compleat	Compleat:HC1565
	AIP GDI1 GDI2 RAB11A RAB11B RAB1A RAB1B RAB7A	O00170 P31150 P50395 P51149 P62491 P62820 Q15907 Q9H0U4	0:0:0:0:0:0:0:0	Havugimana2012	Havugimana2012:C_552
	AFG2A CHM GDI2 RAB1A RAB32 RAB3A RAB4A RAB5A RAB6A RAB7A RABAC1 RABIF UBC ZNF593	O00488 P0CG48 P20336 P20338 P20339 P20340 P24386 P47224 P50395 P51149 P62820 Q13637 Q8NB90 Q9UI14	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5312
	AFG2A CHM CHML GDI2 PA2G4 RAB1A RAB3A RAB4A RAB5A RAB7A RABAC1 RABGGTB RABIF UBC ZNF593	O00488 P0CG48 P20336 P20338 P20339 P24386 P26374 P47224 P50395 P51149 P53611 P62820 Q8NB90 Q9UI14 Q9UQ80	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8408
	BLTP2 GDI2 KIF3A KIF3B KIF3C RAB24 RAB29 RAB4A RAB5A RAB6A RAB7A RABAC1 UBC YIF1B	O14782 O14966 O15066 P0CG48 P20338 P20339 P20340 P50395 P51149 Q14667 Q5BJH7 Q969Q5 Q9UI14 Q9Y496	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8518
	GDI1 GDI2 RAB24 RAB29 RAB4A RAB5A RAB6A RAB9A RABAC1 SLC30A9 TM9SF2 UBC YIF1B YIPF5	O14966 P0CG48 P20338 P20339 P20340 P31150 P50395 P51151 Q5BJH7 Q6PML9 Q969M3 Q969Q5 Q99805 Q9UI14	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6261
	CHML GDI2 RAB1A RAB20 RAB34 RAB4A RAB5A RAB6A RAB7A RABAC1 RABGEF1 UBC YIF1A YIPF5	O95070 P0CG48 P0DI83 P20338 P20339 P20340 P26374 P50395 P51149 P62820 Q969M3 Q9NX57 Q9UI14 Q9UJ41	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9369
	CHM GDI2 RAB24 RAB32 RAB33B RAB4A RAB5A RAB6A RAB7A RABAC1 RABGEF1 UBC YIF1A YIPF5	O95070 P0CG48 P20338 P20339 P20340 P24386 P50395 P51149 Q13637 Q969M3 Q969Q5 Q9H082 Q9UI14 Q9UJ41	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3996
	CHML GDI2 RAB1A RAB24 RAB34 RAB3A RAB4A RAB5A RAB9A RABAC1 YIF1A YIPF1 YIPF5	O95070 P0DI83 P20336 P20338 P20339 P26374 P50395 P51151 P62820 Q969M3 Q969Q5 Q9UI14 Q9Y548	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4158
	CHML GDI2 OCRL RAB1A RAB31 RAB34 RAB3A RAB5A RAB6A RAB7A RABAC1 RABGGTB YIF1A YIPF5	O95070 P0DI83 P20336 P20339 P20340 P26374 P50395 P51149 P53611 P62820 Q01968 Q13636 Q969M3 Q9UI14	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3995

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	3	37786918 27894104 38321535

Sequence, Structure & Domains7

Sequences

Length

445

Mass

50,663

Sequence

MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESASITPLEDLYKRFKIPGSPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVTEGSFVYKGGKIYKVPSTEAEALASSLMGLFEKRRFRKFLVYVANFDEKDPRTFEGIDPKKTTMRDVYKKFDLGQDVIDFTGHALALYRTDDYLDQPCYETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPIEEIIVQNGKVIGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRVICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISFAHNVAAQGKYIAIVSTTVETKEPEKEIRPALELLEPIEQKFVSISDLLVPKDLGTESQIFISRTYDATTHFETTCDDIKNIYKRMTGSEFDFEEMKRKKNDIYGED

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P50395-1; Sequence=Displayed; Name=2; IsoId=P50395-2; Sequence=VSP_043469

Alternative Sequence

86..130; Missing (in isoform 2)

Domain & Motif Annotations

Protein Families

Rab GDI family

Sequence Similarities

Belongs to the Rab GDI family.

Clinical Relevance5

Drugs

PF-9363

Antibody (2)

HPA049290 HPA057668

Interaction Protein (15)

ENSG00000080371ENSG00000084733ENSG00000104388ENSG00000105649ENSG00000108774ENSG00000111737ENSG00000123595ENSG00000129472ENSG00000138069ENSG00000144566ENSG00000154917ENSG00000168118ENSG00000169228ENSG00000174903ENSG00000203879

Interaction Count

Interaction Dataset (5)

biogrid_opencellbiogrid_bioplexbiogrid_opencell_bioplexintact_biogrid_bioplexintact_biogrid_opencell_bioplex

Supporting Publications1

PMID	Title	Abstract
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No abstract available