Protein detail

GDIB

Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2)

Protein symbol GDIB	UniProt ID P50395	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Plasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Rab GDP dissociation inhibitor beta (Rab GDI beta) (Guanosine diphosphate dissociation inhibitor 2) (GDI-2)

Protein Class

Plasma proteinsPredicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000057608

Entrez Gene Symbol

GDI2

Gene Synonym

RABGDIB

Gene Description

GDP dissociation inhibitor 2

Chromosome

Position

5765223-5842132

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Protein Function

Predicted intracellular proteins

Cellular Component

Molecular Function

Reactome

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
GDI2	PAK1	Q13153	T	248	phosphorylation	PhosphoSite
GDI2	PAK1	Q13153	S	382	phosphorylation	PhosphoSite

Ligand-Receptor Signaling

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

1 record.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PAK1	Q13153	GDIB	P50395	Yes	No	No	PhosphoSite_norefPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:33914026

Protein Complex Composition

24 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CHML GDI2 RAB1A RAB24 RAB33B RAB34 RAB4A RAB5A RAB7A RABAC1 RABGEF1 USP6NL YIF1A YIPF5	O95070 P0DI83 P20338 P20339 P26374 P50395 P51149 P62820 Q92738 Q969M3 Q969Q5 Q9H082 Q9UI14 Q9UJ41	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4474
CHML FTSJ1 GDI1 GDI2 RAB1A RAB24 RAB27A RAB34 RAB5A RAB6A RAB9A RABAC1 RABGGTB YIF1A	O95070 P0DI83 P20339 P20340 P26374 P31150 P50395 P51151 P51159 P53611 P62820 Q969Q5 Q9UET6 Q9UI14	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4913
CHM GDI1 GDI2 RAB24 RAB32 RAB4A RAB5A RAB6A RAB9A RABAC1 RABEPK SH3PXD2A YIF1A YIPF5	O95070 P20338 P20339 P20340 P24386 P31150 P50395 P51151 Q13637 Q5TCZ1 Q7Z6M1 Q969M3 Q969Q5 Q9UI14	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5411
CHM GDI2 RAB17 RAB32 RAB4A RAB5A RAB5B RAB6A RAB7A RABAC1 RIN1 YIF1A YIPF5 YWHAE	O95070 P20338 P20339 P20340 P24386 P50395 P51149 P61020 P62258 Q13637 Q13671 Q969M3 Q9H0T7 Q9UI14	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5171
CHM CHML GDI2 RAB1A RAB2A RAB3A RAB4A RAB5A RAB6A RAB7A RABAC1 RABGGTB TBC1D13 UBC YIF1B	P0CG48 P20336 P20338 P20339 P20340 P24386 P26374 P50395 P51149 P53611 P61019 P62820 Q5BJH7 Q9NVG8 Q9UI14	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3643
CHM GDI2 KYAT3 RAB1A RAB32 RAB3A RAB4A RAB5A RAB6A RAB7A RABAC1 RABIF UBC YIF1B	P0CG48 P20336 P20338 P20339 P20340 P24386 P47224 P50395 P51149 P62820 Q13637 Q5BJH7 Q6YP21 Q9UI14	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5276
CHM GDI2 RAB1A RAB2A RAB32 RAB3A RAB4A RAB5A RAB9A RABAC1 TBC1D13 UBC YIF1B YIPF1	P0CG48 P20336 P20338 P20339 P24386 P50395 P51151 P61019 P62820 Q13637 Q5BJH7 Q9NVG8 Q9UI14 Q9Y548	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7536
CHM FTSJ1 GDI1 GDI2 RAB24 RAB27A RAB32 RAB4A RAB5A RAB6A RAB9A RABAC1 UBC YIF1B	P0CG48 P20338 P20339 P20340 P24386 P31150 P50395 P51151 P51159 Q13637 Q5BJH7 Q969Q5 Q9UET6 Q9UI14	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5228
CHM GDI2 RAB17 RAB32 RAB37 RAB4A RAB5A RAB6A RAB7A RABAC1 UBC USP6NL YIF1B YIPF5	P0CG48 P20338 P20339 P20340 P24386 P50395 P51149 Q13637 Q5BJH7 Q92738 Q969M3 Q96AX2 Q9H0T7 Q9UI14	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8763
CHM CHML GDI2 RAB11A RAB1A RAB32 RAB3A RAB4A RAB5A RAB6A RAB7A RABAC1 RABGGTB RABIF	P20336 P20338 P20339 P20340 P24386 P26374 P47224 P50395 P51149 P53611 P62491 P62820 Q13637 Q9UI14	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8820

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	3	37786918 27894104 38321535

Sequence, Structure & Domains

Sequences

Length

445

Mass

50,663

Sequence

MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESASITPLEDLYKRFKIPGSPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDFKVTEGSFVYKGGKIYKVPSTEAEALASSLMGLFEKRRFRKFLVYVANFDEKDPRTFEGIDPKKTTMRDVYKKFDLGQDVIDFTGHALALYRTDDYLDQPCYETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPIEEIIVQNGKVIGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRVICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYVCMISFAHNVAAQGKYIAIVSTTVETKEPEKEIRPALELLEPIEQKFVSISDLLVPKDLGTESQIFISRTYDATTHFETTCDDIKNIYKRMTGSEFDFEEMKRKKNDIYGED

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P50395-1; Sequence=Displayed; Name=2; IsoId=P50395-2; Sequence=VSP_043469

Alternative Sequence

86..130; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Protein Families

Rab GDI family

Sequence Similarities

Belongs to the Rab GDI family.

Clinical Relevance

Drugs

PF-9363

Antibody

HPA049290 HPA057668

Interaction Protein

ENSG00000080371ENSG00000084733ENSG00000104388ENSG00000105649ENSG00000108774ENSG00000111737ENSG00000123595ENSG00000129472ENSG00000138069ENSG00000144566ENSG00000154917ENSG00000168118ENSG00000169228ENSG00000174903ENSG00000203879

Interaction Count

Interaction Dataset

biogrid_opencellbiogrid_bioplexbiogrid_opencell_bioplexintact_biogrid_bioplexintact_biogrid_opencell_bioplex