Protein detail
S26A2
Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2)
Protein symbol S26A2 | UniProt ID | EVMP score 0.25 |
Frequency 5 | Transmembrane count 8 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2)
Protein Class
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
Transmembrane
112..132; Helical; 137..157; Helical; 219..239; Helical; 242..262; Helical; 378..398; Helical; 420..440; Helical; 455..475; Helical; 524..544; Helical
Transmembrane Count
8
Ensembl
Entrez Gene Symbol
Gene Synonym
DTDDTDST
Gene Description
Solute carrier family 26 member 2
Chromosome
5
Position
149960758-149993455
Frequency
5
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificAstrocytes
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
Cellular Component
Molecular Function
- GO:0005452 solute:inorganic anion antiporter activity
- GO:0008271 secondary active sulfate transmembrane transporter activity
- GO:0015106 bicarbonate transmembrane transporter activity
- GO:0015108 chloride transmembrane transporter activity
- GO:0015116 sulfate transmembrane transporter activity
- GO:0019531 oxalate transmembrane transporter activity
Biological Process
Reactome
- R-hsa-3560782 diseases associated with glycosaminoglycan metabolism
- R-hsa-3781865 diseases of glycosylation
- R-hsa-5668914 diseases of metabolism
- R-hsa-5619115 disorders of transmembrane transporters
- R-hsa-1630316 glycosaminoglycan metabolism
- R-hsa-427601 inorganic anion exchange by slc26 transporters
- R-hsa-71387 metabolism of carbohydrates and carbohydrate derivatives
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9958790 slc mediated transport of inorganic anions
- R-hsa-5619102 slc transporter disorders
- R-hsa-174362 transport and metabolism of paps
- R-hsa-382551 transport of small molecules
Canonical Pathways
- M158 Pid integrin4 pathway
- M5887 Naba basement membranes
- M53 Pid integrin3 pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | No | No |
| transmembrane | transmembrane | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometryMass spectrometry [LTQ-FT Ultra]R Sequencing | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
739
Mass
81,662
Sequence
MSSESKEQHNVSPRDSAEGNDSYPSGIHLELQRESSTDFKQFETNDQCRPYHRILIERQEKSDTNFKEFVIKKLQKNCQCSPAKAKNMILGFLPVLQWLPKYDLKKNILGDVMSGLIVGILLVPQSIAYSLLAGQEPVYGLYTSFFASIIYFLLGTSRHISVGIFGVLCLMIGETVDRELQKAGYDNAHSAPSLGMVSNGSTLLNHTSDRICDKSCYAIMVGSTVTFIAGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLGLNLPRTNGVGSLITTWIHVFRNIHKTNLCDLITSLLCLLVLLPTKELNEHFKSKLKAPIPIELVVVVAATLASHFGKLHENYNSSIAGHIPTGFMPPKVPEWNLIPSVAVDAIAISIIGFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCFTTSAALAKTLVKESTGCHTQLSGVVTALVLLLVLLVIAPLFYSLQKSVLGVITIVNLRGALRKFRDLPKMWSISRMDTVIWFVTMLSSALLSTEIGLLVGVCFSIFCVILRTQKPKSSLLGLVEESEVFESVSAYKNLQIKPGIKIFRFVAPLYYINKECFKSALYKQTVNPILIKVAWKKAAKRKIKEKVVTLGGIQDEMSVQLSHDPLELHTIVIDCSAIQFLDTAGIHTLKEVRRDYEAIGIQVLLAQCNPTVRDSLTNGEYCKKEEENLLFYSVYEAMAFAEVSKNQKGVCVPNGLSLSSD
3D Structural Models
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Domain (FT)
568..719; STAS
Region
1..27; Disordered
Protein Families
SLC26A/SulP transporter (TC 2.A.53) family
Sequence Similarities
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Clinical Relevance
Disease Involvement
Disease variantDwarfism
Drugs
Interaction Protein
ENSG00000131981
Interaction Count
1
Interaction Dataset
biogrid_bioplex