Protein detail
S26A2
Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2)
Entry name S26A2 | UniProt ID | EVMP confidence score 0.40 |
Supporting publications (n) 5 | Transmembrane count 8 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Sulfate transporter (Diastrophic dysplasia protein) (Solute carrier family 26 member 2)
Protein Class (7)
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
Transmembrane
112..132; Helical; 137..157; Helical; 219..239; Helical; 242..262; Helical; 378..398; Helical; 420..440; Helical; 455..475; Helical; 524..544; Helical
Transmembrane Count
8
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
DTDDTDST
Gene Description
Solute carrier family 26 member 2
Chromosome
5
Position
149960758-149993455
Supporting publications (n)
5
EVMP confidence score
0.40
Fluorescence & Localization
Cell SpecificAstrocytes
Function & Pathway
Protein Function (5)
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
Cellular Component (5)
Molecular Function (6)
- GO:0005452 solute:inorganic anion antiporter activity
- GO:0008271 secondary active sulfate transmembrane transporter activity
- GO:0015106 bicarbonate transmembrane transporter activity
- GO:0015108 chloride transmembrane transporter activity
- GO:0015116 sulfate transmembrane transporter activity
- GO:0019531 oxalate transmembrane transporter activity
Biological Process (3)
Reactome (12)
- R-hsa-3560782 diseases associated with glycosaminoglycan metabolism
- R-hsa-3781865 diseases of glycosylation
- R-hsa-5668914 diseases of metabolism
- R-hsa-5619115 disorders of transmembrane transporters
- R-hsa-1630316 glycosaminoglycan metabolism
- R-hsa-427601 inorganic anion exchange by slc26 transporters
- R-hsa-71387 metabolism of carbohydrates and carbohydrate derivatives
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9958790 slc mediated transport of inorganic anions
- R-hsa-5619102 slc transporter disorders
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Canonical Pathways (3)
- M158 Pid integrin4 pathway
- M5887 Naba basement membranes
- M53 Pid integrin3 pathway
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence27
Ligand-Receptor Signaling (25)
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | |||||
| cell_surface | cell_surface | Surfaceome | |||||
| cell_surface | cell_surface | OmniPath | |||||
| receptor | receptor | scConnect | Yes | ||||
| transmembrane | transmembrane_predicted | Phobius |
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Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometryMass spectrometry [LTQ-FT Ultra]R Sequencing | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
739
Mass
81,662
Sequence
MSSESKEQHNVSPRDSAEGNDSYPSGIHLELQRESSTDFKQFETNDQCRPYHRILIERQEKSDTNFKEFVIKKLQKNCQCSPAKAKNMILGFLPVLQWLPKYDLKKNILGDVMSGLIVGILLVPQSIAYSLLAGQEPVYGLYTSFFASIIYFLLGTSRHISVGIFGVLCLMIGETVDRELQKAGYDNAHSAPSLGMVSNGSTLLNHTSDRICDKSCYAIMVGSTVTFIAGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLGLNLPRTNGVGSLITTWIHVFRNIHKTNLCDLITSLLCLLVLLPTKELNEHFKSKLKAPIPIELVVVVAATLASHFGKLHENYNSSIAGHIPTGFMPPKVPEWNLIPSVAVDAIAISIIGFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCFTTSAALAKTLVKESTGCHTQLSGVVTALVLLLVLLVIAPLFYSLQKSVLGVITIVNLRGALRKFRDLPKMWSISRMDTVIWFVTMLSSALLSTEIGLLVGVCFSIFCVILRTQKPKSSLLGLVEESEVFESVSAYKNLQIKPGIKIFRFVAPLYYINKECFKSALYKQTVNPILIKVAWKKAAKRKIKEKVVTLGGIQDEMSVQLSHDPLELHTIVIDCSAIQFLDTAGIHTLKEVRRDYEAIGIQVLLAQCNPTVRDSLTNGEYCKKEEENLLFYSVYEAMAFAEVSKNQKGVCVPNGLSLSSD
3D Structural Models
3D Structure
Electron microscopy (4)
Domain & Motif Annotations
Domain (FT)
568..719; STAS
Region
1..27; Disordered
Protein Families
SLC26A/SulP transporter (TC 2.A.53) family
Sequence Similarities
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
Clinical Relevance
Disease Involvement (2)
Disease variantDwarfism
Related Diseases
Drugs (7)
Interaction Protein
ENSG00000131981
Interaction Count
1
Interaction Dataset
biogrid_bioplex
Supporting Publications5
| PMID | Title | Related sentences |
|---|---|---|
| 24700864 | Human urinary exosomes as innate immune effectors. | No related sentences available |
| 26775013 | Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers. | No related sentences available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 35085587 | Diagnosis of invasive non-functional pituitary adenomas using exosomal biomarkers. | No related sentences available |
| 40311616 | Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer. | No related sentences available |