Protein detail

TUB

Tubby protein homolog

Entry name TUB	UniProt ID P50607	EVMP confidence score 0.38
Supporting publications (n) 6	Transmembrane count	Protein classification Disease related genesPredicted intracellular proteins

Basic Information

Protein Names

Tubby protein homolog

Protein Class (2)

Disease related genesPredicted intracellular proteins

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000166402

Entrez Gene Symbol

TUB

Gene Synonym

rd5

Gene Description

TUB bipartite transcription factor

Chromosome

Position

8019244-8106243

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization

Cell SpecificMicrogliaSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (3)

Biological Process (3)

Mediation Categories (3)

Clinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence188

Ligand-Receptor Signaling (17)

17 records.

Category	Parent	Database	Transmitter	Receiver	Secreted
receptor	receptor	OmniPath		Yes	Yes
ecm	ecm	MatrixDB	Yes		Yes
ecm	ecm	OmniPath	Yes		Yes
extracellular	extracellular	OmniPath			Yes
intracellular	intracellular	LOCATE			Yes
intracellular	intracellular	ComPPI			Yes
intracellular	intracellular	GO_Intercell			Yes
intracellular	intracellular	UniProt_location			Yes
intracellular	intracellular	OmniPath			Yes
plasma_membrane	plasma_membrane	UniProt_location			Yes

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Protein Complex Composition (170)

170 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
TUBG1 TUBGCP4 TUBGCP5 TUBGCP6	P23258 Q96RT7 Q96RT8 Q9UGJ1	4:1:1:2	PDB	PDB:7qje
TUBG1 TUBGCP4	P23258 Q9UGJ1	0:0	Havugimana2012	Havugimana2012:C_6
ACAT1 MALSU1 MIER1 SSBP1 TUBB1	P24752 Q04837 Q8N108 Q96EH3 Q9H4B7	0:0:0:0:0	Havugimana2012	Havugimana2012:C_425
RBM23 RPA1 TBCB TUBA4A	P27694 P68366 Q86U06 Q99426	1:1:1:1	NetworkBlastCompleat	Compleat:HC9545
CLIP1 TUBA1B	P30622 P68363	1:1	PDB	PDB:2e4h
CLIP1 GPHN MAPRE2 TBCB TUBA4A	P30622 P68366 Q15555 Q99426 Q9NQX3	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9823
DNAJA1 TUBA1C TUBB4B TUBB6	P31689 P68371 Q9BQE3 Q9BUF5	0:0:0:0	hu.MAP2
DNAJA1 TUBA1C TUBB6	P31689 Q9BQE3 Q9BUF5	0:0:0	hu.MAP2
HSPA4 STUB1	P34932 Q9UNE7	0:0	hu.MAP2
ARL2 CAPS EML6 TUBB2B	P36404 Q13938 Q6ZMW3 Q9BVA1	0:0:0:0	hu.MAP

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	3	38343172 40222457 40595564

Sequence, Structure & Domains

Sequences

Length

506

Mass

55,651

Sequence

MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P50607-1; Sequence=Displayed; Name=2; IsoId=P50607-2; Sequence=VSP_023030

Alternative Sequence

1..13; MTSKPHSDWIPYS -> MGARTPLPSFWVSFFAETGILFPGGTPWPMGSQHSKQHRKPGPLKRGHRRDRRTTRRKYWKEGREIAR (in isoform 2)

3D Structural Models

Turn

355..357; 434..437

Helix

251..255; 276..278; 318..322; 406..408; 410..415; 488..500

Beta Strand

265..272; 283..289; 295..303; 311..316; 329..334; 338..348; 358..363; 366..372; 385..390; 421..427; 431..433; 438..440; 455..459; 467..474; 477..482

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

70..87; Low complexity; 101..116; Low complexity; 196..206; Acidic residues; 207..221; Low complexity; 230..243; Low complexity

Region

36..244; Disordered

Protein Families

TUB family

Sequence Similarities

Belongs to the TUB family.

Clinical Relevance

Disease Involvement

Obesity

Related Diseases (12)

Obesity Bladder cancer Brain cancer Breast cancer Central nervous system disease Epidermal dysplasias Gout Immune system disease Ovarian cancer Pancreatic cancer Sarcoma Solid tumour/cancer

Biomarker

Discontinued in Phase 3; Phase 1; Approved; Investigative; Discontinued in Phase 1; Phase 3; Phase 2

Drugs (17)

VINORELBINE COLCHICINE LISAVANBULIN NULL CRYPTOPHYCIN 52 INDIBULIN SOBLIDOTIN ERIBULIN MESYLATE E-7974 DOLASTATIN-10 BMS-184476 IXABEPILONE BMS-275183 BMS-188797 CABAZITAXEL MILATAXEL DOCETAXEL ANHYDROUS

Antibody (2)

HPA017997 HPA049019

Supporting Publications6

PMID	Title	Related sentences
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No related sentences available
35111156	Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response.	No related sentences available
37686366	Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.	No related sentences available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No related sentences available
39290459	Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease.	No related sentences available
40091455	Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.	No related sentences available