Protein detail

TUB

Tubby protein homolog

Entry name TUB	UniProt ID P50607	EVMP confidence score 0.38
Supporting publications (n) 6	Transmembrane count	Protein classification Disease related genesPredicted intracellular proteins

Basic Information

Protein Names

Tubby protein homolog

Protein Class (2)

Disease related genesPredicted intracellular proteins

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000166402

Entrez Gene Symbol

TUB

Gene Synonym

rd5

Gene Description

TUB bipartite transcription factor

Chromosome

Position

8019244-8106243

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization

Cell SpecificMicrogliaSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (3)

Biological Process (3)

Mediation Categories (3)

Clinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence188

Ligand-Receptor Signaling (17)

17 records.

Category	Parent	Database	Transmitter	Receiver	Secreted
plasma_membrane	plasma_membrane	OmniPath			Yes
secreted	secreted	UniProt_keyword			Yes
secreted	secreted	UniProt_location			Yes
secreted	secreted	OmniPath			Yes
ligand	ligand	CellChatDB	Yes		Yes
ligand	ligand	OmniPath	Yes		Yes
receptor	receptor	CellCellInteractions		Yes	Yes

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Protein Complex Composition (170)

170 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ARL2 CAPS TUBB2B	P36404 Q13938 Q9BVA1	0:0:0	hu.MAP2
ABCF2 EIF2S3 TUBA1B	P41091 P68363 Q9UG63	0:0:0	hu.MAP
CLIP4 DYNC1H1 HCFC1 KIF5A PAFAH1B1 TUBA1A	P43034 P51610 Q12840 Q14204 Q71U36 Q8N3C7	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8824
CLIP4 DYNC1H1 PAFAH1B1 PHB2 TIMM50 TUBA3E	P43034 Q14204 Q3ZCQ8 Q6PEY2 Q8N3C7 Q99623	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9241
TUBA1B TUBB3	P68363 Q13509	8:8	PDB	PDB:7pjfPDB:7m18PDB:6e7bPDB:9f3bPDB:6s8lPDB:7sj7PDB:5ij9PDB:9f3hPDB:8vt7PDB:5ij0PDB:7sj8PDB:7sjaPDB:7lxbPDB:7m20
MATCAP1 TUBA1B TUBB3	P68363 Q13509 Q68EN5	2:2:2	PDB	PDB:7z6s
MAPRE3 TUBA1B TUBB3	P68363 Q13509 Q9UPY8	6:6:2	PDB	PDB:9f3rPDB:9f3sPDB:7sj9
LTV1 RCN1 TUBA1B TUBB2A TUBB2B	P68363 Q13885 Q15293 Q96GA3 Q9BVA1	0:0:0:0:0	Havugimana2012	Havugimana2012:C_406
TCP11L2 TUBA1B TUBA3E	P68363 Q6PEY2 Q8N4U5	0:0:0	hu.MAP2
SVBP TUBA1B VASH1	P68363 Q7L8A9 Q8N300	1:1:1	PDB	PDB:6j8o

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	3	38343172 40222457 40595564

Sequence, Structure & Domains

Sequences

Length

506

Mass

55,651

Sequence

MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P50607-1; Sequence=Displayed; Name=2; IsoId=P50607-2; Sequence=VSP_023030

Alternative Sequence

1..13; MTSKPHSDWIPYS -> MGARTPLPSFWVSFFAETGILFPGGTPWPMGSQHSKQHRKPGPLKRGHRRDRRTTRRKYWKEGREIAR (in isoform 2)

3D Structural Models

Turn

355..357; 434..437

Helix

251..255; 276..278; 318..322; 406..408; 410..415; 488..500

Beta Strand

265..272; 283..289; 295..303; 311..316; 329..334; 338..348; 358..363; 366..372; 385..390; 421..427; 431..433; 438..440; 455..459; 467..474; 477..482

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

70..87; Low complexity; 101..116; Low complexity; 196..206; Acidic residues; 207..221; Low complexity; 230..243; Low complexity

Region

36..244; Disordered

Protein Families

TUB family

Sequence Similarities

Belongs to the TUB family.

Clinical Relevance

Disease Involvement

Obesity

Related Diseases (12)

Obesity Bladder cancer Brain cancer Breast cancer Central nervous system disease Epidermal dysplasias Gout Immune system disease Ovarian cancer Pancreatic cancer Sarcoma Solid tumour/cancer

Biomarker

Discontinued in Phase 3; Phase 1; Approved; Investigative; Discontinued in Phase 1; Phase 3; Phase 2

Drugs (17)

VINORELBINE COLCHICINE LISAVANBULIN NULL CRYPTOPHYCIN 52 INDIBULIN SOBLIDOTIN ERIBULIN MESYLATE E-7974 DOLASTATIN-10 BMS-184476 IXABEPILONE BMS-275183 BMS-188797 CABAZITAXEL MILATAXEL DOCETAXEL ANHYDROUS

Antibody (2)

HPA017997 HPA049019

Supporting Publications6

PMID	Title	Related sentences
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No related sentences available
35111156	Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response.	No related sentences available
37686366	Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.	No related sentences available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No related sentences available
39290459	Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease.	No related sentences available
40091455	Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.	No related sentences available