Protein detail

TUB

Tubby protein homolog

Entry name TUB	UniProt ID P50607	EVMP confidence score 0.38
Supporting publications (n) 6	Transmembrane count	Protein classification Disease related genesPredicted intracellular proteins

Basic Information

Protein Names

Tubby protein homolog

Protein Class (2)

Disease related genesPredicted intracellular proteins

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Ensembl

ENSG00000166402

Entrez Gene Symbol

TUB

Gene Synonym

rd5

Gene Description

TUB bipartite transcription factor

Chromosome

Position

8019244-8106243

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization

Cell SpecificMicrogliaSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes

Function & Pathway

Protein Function (2)

Disease related genes
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (3)

Biological Process (3)

Mediation Categories (3)

Clinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence188

Ligand-Receptor Signaling (17)

17 records.

Category	Parent	Database	Transmitter	Receiver	Secreted
plasma_membrane	plasma_membrane	OmniPath			Yes
secreted	secreted	UniProt_keyword			Yes
secreted	secreted	UniProt_location			Yes
secreted	secreted	OmniPath			Yes
ligand	ligand	CellChatDB	Yes		Yes
ligand	ligand	OmniPath	Yes		Yes
receptor	receptor	CellCellInteractions		Yes	Yes

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Protein Complex Composition (170)

170 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Profilin 1 complex	ACTB ACTG1 CLTC HSPA8 PFN1 POTEF POTEI POTEJ TUBB2A TUBB2B VCP	A5A3E0 P07737 P0CG38 P0CG39 P11142 P55072 P60709 P63261 Q00610 Q13885 Q9BVA1	1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC1308	9463375
Profilin 1 complex	ACTG1 CLTC HSPA8 PFN1 TUBB2B VCP	P07737 P11142 P55072 P63261 Q00610 Q9BVA1	1:1:1:1:1:1	CompleatCORUM	Compleat:HC3403CORUM:2837	9463375
SNCA-TUBB3 complex	SNCA TUBB3	P37840 Q13509	0:0	CORUM	CORUM:7241	25028513
SNW1 complex	ABCF2 CDC5L DDB1 DDX23 EEF1A1 EEF1G EFTUD2 HNRNPU HSPA5 MATR3 MSH2 PFKL PRPF8 SFPQ SNRNP200 SNW1 TUBB UBR5	O75643 O95071 P07437 P11021 P17858 P23246 P26641 P43243 P43246 P68104 Q00839 Q13573 Q15029 Q16531 Q6P2Q9 Q99459 Q9BUQ8 Q9UG63	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	CompleatCORUM	Compleat:HC2657CORUM:1335	12840015
TBCE-TBCB-tubulin(alpha) complex	TBCB TBCE TUBA1A	Q15813 Q71U36 Q99426	0:0:0	CORUM	CORUM:6714	28126905
Tubulins	TUBA1A TUBA1B TUBA1C TUBA3C TUBA3D TUBA3E TUBA4A TUBA8 TUBAL3 TUBB TUBB1 TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBB8 TUBE1	A6NHL2 P04350 P07437 P0DPH7 P0DPH8 P68363 P68366 P68371 Q13509 Q13885 Q3ZCM7 Q6PEY2 Q71U36 Q9BQE3 Q9BUF5 Q9BVA1 Q9H4B7 Q9NY65 Q9UJT0	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC616	15321725
g-TuRC complex	TUBGCP2 TUBGCP3 TUBGCP4 TUBGCP5 TUBGCP6	Q96CW5 Q96RT7 Q96RT8 Q9BSJ2 Q9UGJ1	0:0:0:0:0	SIGNOR	SIGNOR:SIGNOR-C282
gamma-tubulin complex	BLOC1S2 CEP290 CKAP5 MARK4 TUBG1 UXT	O15078 P23258 Q14008 Q6QNY1 Q96L34 Q9UBK9	1:1:1:1:1:1	Compleat	Compleat:HC3065	15381421 14718566 14594945 16682973 16221885 9566969
gamma-tubulin complex	TUBG1 TUBG2 TUBGCP2 TUBGCP3	P23258 Q96CW5 Q9BSJ2 Q9NRH3	1:1:1:1	Compleat	Compleat:HC2915	9384578
gamma-tubulin ring complex	BRCA1 MZT1 MZT2A MZT2B TUBGCP4 TUBGCP5 TUBGCP6	P38398 Q08AG7 Q6NZ67 Q6P582 Q96RT7 Q96RT8 Q9UGJ1	1:1:1:1:1:1:1	Compleat	Compleat:HC1642	12214252 10562286 11694571

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometry	3	38343172 40222457 40595564

Sequence, Structure & Domains

Sequences

Length

506

Mass

55,651

Sequence

MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P50607-1; Sequence=Displayed; Name=2; IsoId=P50607-2; Sequence=VSP_023030

Alternative Sequence

1..13; MTSKPHSDWIPYS -> MGARTPLPSFWVSFFAETGILFPGGTPWPMGSQHSKQHRKPGPLKRGHRRDRRTTRRKYWKEGREIAR (in isoform 2)

3D Structural Models

Turn

355..357; 434..437

Helix

251..255; 276..278; 318..322; 406..408; 410..415; 488..500

Beta Strand

265..272; 283..289; 295..303; 311..316; 329..334; 338..348; 358..363; 366..372; 385..390; 421..427; 431..433; 438..440; 455..459; 467..474; 477..482

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

70..87; Low complexity; 101..116; Low complexity; 196..206; Acidic residues; 207..221; Low complexity; 230..243; Low complexity

Region

36..244; Disordered

Protein Families

TUB family

Sequence Similarities

Belongs to the TUB family.

Clinical Relevance

Disease Involvement

Obesity

Related Diseases (12)

Obesity Bladder cancer Brain cancer Breast cancer Central nervous system disease Epidermal dysplasias Gout Immune system disease Ovarian cancer Pancreatic cancer Sarcoma Solid tumour/cancer

Biomarker

Discontinued in Phase 3; Phase 1; Approved; Investigative; Discontinued in Phase 1; Phase 3; Phase 2

Drugs (17)

VINORELBINE COLCHICINE LISAVANBULIN NULL CRYPTOPHYCIN 52 INDIBULIN SOBLIDOTIN ERIBULIN MESYLATE E-7974 DOLASTATIN-10 BMS-184476 IXABEPILONE BMS-275183 BMS-188797 CABAZITAXEL MILATAXEL DOCETAXEL ANHYDROUS

Antibody (2)

HPA017997 HPA049019

Supporting Publications6

PMID	Title	Related sentences
33709510	Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection.	No related sentences available
35111156	Exosomes Recovered From the Plasma of COVID-19 Patients Expose SARS-CoV-2 Spike-Derived Fragments and Contribute to the Adaptive Immune Response.	No related sentences available
37686366	Identification of a Non-Invasive Urinary Exosomal Biomarker for Diabetic Nephropathy Using Data-Independent Acquisition Proteomics.	No related sentences available
38321535	Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles.	No related sentences available
39290459	Urinary extracellular vesicles as a monitoring tool for renal damage in patients not meeting criteria for chronic kidney disease.	No related sentences available
40091455	Potential Role of Menstrual Fluid-Derived Small Extracellular Vesicle Proteins in Endometriosis Pathogenesiss.	No related sentences available