Protein detail
TUB
Tubby protein homolog
Protein symbol TUB | UniProt ID | EVMP score 0.50 |
Frequency 6 | Transmembrane count | Protein classification Disease related genesPredicted intracellular proteins |
Basic Information
Protein Names
Tubby protein homolog
Protein Class
Disease related genesPredicted intracellular proteins
Protein Function
- Disease related genes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
rd5
Gene Description
TUB bipartite transcription factor
Chromosome
11
Position
8019244-8106243
Frequency
6
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificMicrogliaSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificeosinophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Disease related genes
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
17 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | OmniPath | No | No | Yes | No | No |
| secreted | secreted | UniProt_keyword | No | No | Yes | No | No |
| secreted | secreted | UniProt_location | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
| ligand | ligand | CellChatDB | Yes | No | Yes | No | No |
| ligand | ligand | OmniPath | Yes | No | Yes | No | No |
| receptor | receptor | CellCellInteractions | No | Yes | Yes | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
170 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ATAD3ATUBA1CTUBB4ATUBB6 | P04350Q9BQE3Q9BUF5Q9NVI7 | 0:0:0:0 | hu.MAP | |||
| ANP32BNOP10RBM4BRPLP0TUBA8 | P05388Q92688Q9BQ04Q9NPE3Q9NY65 | 0:0:0:0:0 | hu.MAP2 | |||
| CSNK1A1HSP90AA1SYT11SYT9TUBB | P07437P07900P48729Q86SS6Q9BT88 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6200 | ||
| CCT2CCT3CCT4CCT5CCT6ACCT7CCT8TCP1TUBB | P07437P17987P40227P48643P49368P50990P50991P78371Q99832 | 1:2:2:2:2:2:2:2:2 | PDB | PDB:7tubPDB:7ttnPDB:7tttPDB:7trgPDB:7x0s | ||
| CADQ99867TUBA1ATUBA1BTUBA1CTUBA4ATUBBTUBB2ATUBB3TUBB4BTUBB6 | P07437P27708P68363P68366P68371Q13509Q13885Q71U36Q99867Q9BQE3Q9BUF5 | 0:0:0:0:0:0:0:0:0:0:0 | Havugimana2012 | Havugimana2012:C_596 | ||
| CLIP1DNAH8HCFC1PAFAH1B1TUBA1ATUBB | P07437P30622P43034P51610Q71U36Q96JB1 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9767 | ||
| POLR2BTUBBTUBB2ATUBB4B | P07437P30876P68371Q13885 | 0:0:0:0 | hu.MAP | |||
| TUBA1BTUBB | P07437P68363 | 6:6 | PDB | PDB:9bp6PDB:5n5nPDB:6i2iPDB:8v2j | ||
| CAMSAP1TUBA1BTUBB | P07437P68363Q5T5Y3 | 2:2:1 | PDB | PDB:6qusPDB:6qvj | ||
| TUBBTUBB4B | P07437P68371 | 0:0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
506
Mass
55,651
Sequence
MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAALAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P50607-1; Sequence=Displayed; Name=2; IsoId=P50607-2; Sequence=VSP_023030
Alternative Sequence
1..13; MTSKPHSDWIPYS -> MGARTPLPSFWVSFFAETGILFPGGTPWPMGSQHSKQHRKPGPLKRGHRRDRRTTRRKYWKEGREIAR (in isoform 2)
3D Structural Models
Turn
355..357; 434..437
Helix
251..255; 276..278; 318..322; 406..408; 410..415; 488..500
Beta Strand
265..272; 283..289; 295..303; 311..316; 329..334; 338..348; 358..363; 366..372; 385..390; 421..427; 431..433; 438..440; 455..459; 467..474; 477..482
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
70..87; Low complexity; 101..116; Low complexity; 196..206; Acidic residues; 207..221; Low complexity; 230..243; Low complexity
Region
36..244; Disordered
Protein Families
TUB family
Sequence Similarities
Belongs to the TUB family.
Clinical Relevance
Disease Involvement
Obesity
Related Diseases
Biomarker
Discontinued in Phase 3; Phase 1; Approved; Investigative; Discontinued in Phase 1; Phase 3; Phase 2
Drugs