Protein detail
ATP4B
Potassium-transporting ATPase subunit beta (Gastric H(+)/K(+) ATPase subunit beta) (Proton pump beta chain)
Protein symbol ATP4B | UniProt ID | EVMP score 0.50 |
Frequency 2 | Transmembrane count 1 | Protein classification FDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Potassium-transporting ATPase subunit beta (Gastric H(+)/K(+) ATPase subunit beta) (Proton pump beta chain)
Protein Class
FDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters
Protein Function
- Transporters:Primary Active Transporters
- FDA approved drug targets:Small molecule drugs
Transmembrane
37..57; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
ATP6B
Gene Description
ATPase H+/K+ transporting subunit beta
Chromosome
13
Position
113648804-113658198
Frequency
2
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificBreast lactating cells
Function & Pathway
Protein Function
- Transporters:Primary Active Transporters
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
- M190 Pid tcr jnk pathway
- M141 Pid pi3kci pathway
- M50 Pid ptp1b pathway
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
27 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| transporter | transporter | Surfaceome | No | Yes | No | No | No |
| hk_atpase | transporter | HGNC | No | Yes | No | No | No |
| transporter | transporter | HGNC | No | Yes | No | No | No |
| auxiliary_transport_unit | transporter | Almen2009 | No | Yes | No | No | No |
| atp1b | transporter | Surfaceome | No | Yes | No | No | No |
| auxillarytransportunit | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
291
Mass
33,367
Sequence
MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLYVLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGYSPAAQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFIIKMNRIVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPHYSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIEK
3D Structural Models
Domain & Motif Annotations
Domain (CC)
The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
Region
194..291; immunoglobulin-like
Protein Families
X(+)/potassium ATPases subunit beta family
Sequence Similarities
Belongs to the X(+)/potassium ATPases subunit beta family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs
VONOPRAZAN FUMARATEESOMEPRAZOLE STRONTIUMESOMEPRAZOLE SODIUMCLOTRIMAZOLERABEPRAZOLEOMEPRAZOLE MAGNESIUMFEXUPRAZANADPPIP2COMPOUND 5 [PMID: 29579323]ADENOSINE MONOPHOSPHATEADENOSINE TRIPHOSPHATEMECLOFENAMATEILAPRAZOLETEGOPRAZANAMP-PNP9-PHENANTHROLCA2+OMEPRAZOLELANSOPRAZOLECOMPOUND 6 [PMID: 29579323]BTP2SPERMINELBADECAVANADATEADENOSINEESOMEPRAZOLE MAGNESIUMPANTOPRAZOLE SODIUM