Protein detail

ATP4B

Potassium-transporting ATPase subunit beta (Gastric H(+)/K(+) ATPase subunit beta) (Proton pump beta chain)

Entry name
ATP4B
UniProt ID
P51164
EVMP confidence score
0.40
Supporting publications (n)
2
Transmembrane count
1
Protein classification
FDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters
Basic Information
Protein Names
Potassium-transporting ATPase subunit beta (Gastric H(+)/K(+) ATPase subunit beta) (Proton pump beta chain)
Protein Class (4)
FDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters
Protein Function (2)
  • Transporters:Primary Active Transporters
  • FDA approved drug targets:Small molecule drugs
Transmembrane
37..57; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
ENSG00000186009
Entrez Gene Symbol
ATP4B
Gene Synonym
ATP6B
Gene Description
ATPase H+/K+ transporting subunit beta
Chromosome
13
Position
113648804-113658198
Supporting publications (n)
2
EVMP confidence score
0.40
Fluorescence & Localization
ATP4B fluorescence
Cell SpecificBreast lactating cells
Function & Pathway
Protein Function (2)
  • Transporters:Primary Active Transporters
  • FDA approved drug targets:Small molecule drugs
Cellular Component (4)
Molecular Function (4)
Biological Process (3)
KEGG (4)
Reactome (3)
Canonical Pathways (3)
  • M190 Pid tcr jnk pathway
  • M141 Pid pi3kci pathway
  • M50 Pid ptp1b pathway
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence28

Ligand-Receptor Signaling (27)

27 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembraneUniProt_location
transmembranetransmembraneUniProt_topology
transmembranetransmembraneUniProt_keyword
transmembrane_predictedtransmembraneOmniPath
transmembranetransmembraneLOCATE
transmembranetransmembraneRamilowski_location
transmembranetransmembraneOmniPath
plasma_membraneplasma_membraneUniProt_location
apical_cell_membraneplasma_membraneUniProt_location
plasma_membraneplasma_membraneOmniPath
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationMass spectrometry52316151328396511327954144121688432795414
Sequence, Structure & Domains

Sequences

Length
291
Mass
33,367
Sequence
MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLYVLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGYSPAAQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFIIKMNRIVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPHYSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIEK

Domain & Motif Annotations

Domain (CC)
The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.
Region
194..291; immunoglobulin-like
Protein Families
X(+)/potassium ATPases subunit beta family
Sequence Similarities
Belongs to the X(+)/potassium ATPases subunit beta family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Drug Targets
FDA approved drug targets
Drugs (28)
VONOPRAZAN FUMARATEESOMEPRAZOLE STRONTIUMESOMEPRAZOLE SODIUMCLOTRIMAZOLERABEPRAZOLEOMEPRAZOLE MAGNESIUMFEXUPRAZANADPPIP2COMPOUND 5 [PMID: 29579323]ADENOSINE MONOPHOSPHATEADENOSINE TRIPHOSPHATEMECLOFENAMATEILAPRAZOLETEGOPRAZANAMP-PNP9-PHENANTHROLCA2+OMEPRAZOLELANSOPRAZOLECOMPOUND 6 [PMID: 29579323]BTP2SPERMINELBADECAVANADATEADENOSINEESOMEPRAZOLE MAGNESIUMPANTOPRAZOLE SODIUM
Antibody (2)
HPA045400HPA052649
Supporting Publications2
PMIDTitleRelated sentences
32795414Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
39940641Disease-Associated Signatures Persist in Extracellular Vesicles from Reprogrammed Cells of Osteoarthritis Patients.No related sentences available