Protein detail

ATP4B

Potassium-transporting ATPase subunit beta (Gastric H(+)/K(+) ATPase subunit beta) (Proton pump beta chain)

Entry name ATP4B	UniProt ID P51164	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count 1	Protein classification FDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Potassium-transporting ATPase subunit beta (Gastric H(+)/K(+) ATPase subunit beta) (Proton pump beta chain)

Protein Class (4)

FDA approved drug targetsMetabolic proteinsPredicted membrane proteinsTransporters

Protein Function (2)

Transporters:Primary Active Transporters
FDA approved drug targets:Small molecule drugs

Transmembrane

37..57; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000186009

Entrez Gene Symbol

ATP4B

Gene Synonym

ATP6B

Gene Description

ATPase H+/K+ transporting subunit beta

Chromosome

Position

113648804-113658198

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Cell SpecificBreast lactating cells

Function & Pathway8

Protein Function (2)

Transporters:Primary Active Transporters
FDA approved drug targets:Small molecule drugs

Cellular Component (4)

Molecular Function (4)

Biological Process (3)

KEGG (4)

Reactome (3)

Canonical Pathways (3)

M190 Pid tcr jnk pathway
M141 Pid pi3kci pathway
M50 Pid ptp1b pathway

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationImmune mediation

Relations & Evidence28

Ligand-Receptor Signaling (27)

27 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
apical_cell_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry	5	23161513 28396511 32795414 41216884 32795414

Sequence, Structure & Domains7

Sequences

Length

291

Mass

33,367

Sequence

MAALQEKKTCGQRMEEFQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLYVLMQTVDPYTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGYSPAAQEDSINCTSEQYFFQESFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFIIKMNRIVKFLPSNGSAPRVDCAFLDQPRELGQPLQVKYYPPNGTFSLHYFPYYGKKAQPHYSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFKLKIEK

Domain & Motif Annotations

Domain (CC)

The C-terminal lobe folds into an immunoglobulin-like domain and mediates cell adhesion properties.

Region

194..291; immunoglobulin-like

Protein Families

X(+)/potassium ATPases subunit beta family

Sequence Similarities

Belongs to the X(+)/potassium ATPases subunit beta family.

Clinical Relevance4

Disease Involvement

FDA approved drug targets

Drug Targets

FDA approved drug targets

Antibody (2)

HPA045400 HPA052649

Supporting Publications2

PMID	Title	Abstract
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
39940641	Disease-Associated Signatures Persist in Extracellular Vesicles from Reprogrammed Cells of Osteoarthritis Patients.	No abstract available