Protein detail
GPC3
Glypican-3 (GTR2-2) (Intestinal protein OCI-5) (MXR7) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit]
Protein symbol GPC3 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count | Protein classification |
Basic Information
Protein Names
Glypican-3 (GTR2-2) (Intestinal protein OCI-5) (MXR7) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit]
Protein Function
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Cancers:Cancers of the urinary system
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Tissue Specificfallopian tubeCell SpecificEndometrial ciliated cellsSingle-Nuclei Brain Specificependymal cell
Function & Pathway
Protein Function
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Cancers:Cancers of the urinary system
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
Cellular Component
Biological Process
Reactome
- R-hsa-9694614 attachment and entry
- R-hsa-3560783 defective b4galt7 causes eds progeroid type
- R-hsa-3656237 defective ext2 causes exostoses 2
- R-hsa-9918485 dengue virus attachment and entry
- R-hsa-9918481 dengue virus host interactions
- R-hsa-9839923 dengue virus infection
- R-hsa-3560782 diseases associated with glycosaminoglycan metabolism
- R-hsa-3781865 diseases of glycosylation
- R-hsa-5668914 diseases of metabolism
- R-hsa-9772572 early sars cov 2 infection events
- R-hsa-1630316 glycosaminoglycan metabolism
- R-hsa-1971475 glycosaminoglycan protein linkage region biosynthesis
- R-hsa-1638091 heparan sulfate heparin hs gag metabolism
- R-hsa-2022928 hs gag biosynthesis
- R-hsa-2024096 hs gag degradation
- R-hsa-5663205 infectious disease
- R-hsa-71387 metabolism of carbohydrates and carbohydrate derivatives
- R-hsa-6806667 metabolism of fat soluble vitamins
- R-hsa-196854 metabolism of vitamins and cofactors
- R-hsa-597592 post translational protein modification
- R-hsa-381426 regulation of insulin like growth factor igf transport and uptake by insulin like growth factor binding proteins igfbps
- R-hsa-9820952 respiratory syncytial virus infection pathway
- R-hsa-9820960 respiratory syncytial virus rsv attachment and entry
- R-hsa-9833110 rsv host interactions
- R-hsa-9694516 sars cov 2 infection
- R-hsa-9679506 sars cov infections
- R-hsa-9709957 sensory perception
- R-hsa-9824446 viral infection pathways
- R-hsa-2187338 visual phototransduction
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
35 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | GO_Intercell | No | Yes | Yes | No | No |
| receptor | receptor | Baccin2019 | No | Yes | Yes | No | No |
| receptor | receptor | OmniPath | No | Yes | Yes | No | No |
| extracellular | extracellular | LOCATE | No | No | Yes | No | No |
| extracellular | extracellular | OmniPath | No | No | Yes | No | No |
| intracellular | intracellular | LOCATE | No | No | Yes | No | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | No | No |
| intracellular | intracellular | OmniPath | No | No | Yes | No | No |
| glypican | receptor_regulator | HGNC | Yes | No | Yes | No | No |
| glypican | receptor_regulator | Matrisome | Yes | No | Yes | No | No |
Page 1 of 4Next
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GPC3 | P51654 | SHH | Q15465 | Yes | Yes | No | SignaLink3 | SignaLink3:18505598SignaLink3:23331499 |
| GPC3 | P51654 | DPP4 | P27487 | Yes | No | Yes | SIGNOR | SIGNOR:17549790 |
Protein Complex Composition
0 records.
Sequence, Structure & Domains
Sequences
Length
580
Mass
65,563
Sequence
MAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYTQLMNPGLPDSALDINECLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNAGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVAHVEHEETLSSRRRELIQKLKSFISFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSMPKGRVLDKNLDEEGFESGDCGDDEDECIGGSGDGMIKVKNQLRFLAELAYDLDVDDAPGNSQQATPKDNEISTFHNLGNVHSPLKLLTSMAISVVCFFFLVH
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P51654-1; Sequence=Displayed; Name=2; Synonyms=Variant B; IsoId=P51654-2; Sequence=VSP_046117; Name=3; Synonyms=Variant C; IsoId=P51654-3; Sequence=VSP_046703
Alternative Sequence
59..112; Missing (in isoform 2); 344; T -> TETEKKIWHFKYPIFFLCIGLDLQ (in isoform 3)
3D Structural Models
Turn
205..210; 397..403
Helix
75..133; 135..137; 140..156; 163..181; 195..204; 211..243; 250..260; 262..265; 275..285; 287..290; 292..309; 316..321; 323..335; 338..348; 384..396; 405..411; 457..474
Beta Strand
63..65; 420..423; 425..431
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Protein Families
Glypican family
Sequence Similarities
Belongs to the glypican family.
Clinical Relevance
Biomarker
Phase 2; Phase 1
Drug Targets
Clinical trial target