Protein detail
GPC3
Glypican-3 (GTR2-2) (Intestinal protein OCI-5) (MXR7) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit]
Entry name GPC3 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information6
Protein Names
Glypican-3 (GTR2-2) (Intestinal protein OCI-5) (MXR7) [Cleaved into: Glypican-3 alpha subunit; Glypican-3 beta subunit]
Protein Function (5)
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Cancers:Cancers of the urinary system
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
Ensembl
Entrez Gene Symbol
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization4
Tissue Specificfallopian tubeCell SpecificEndometrial ciliated cellsSingle-Nuclei Brain Specificependymal cell
Function & Pathway7
Protein Function (5)
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Cancers:Cancers of the urinary system
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
Cellular Component (7)
Molecular Function (2)
Biological Process (3)
Reactome (29)
- R-hsa-9694614 attachment and entry
- R-hsa-3560783 defective b4galt7 causes eds progeroid type
- R-hsa-3656237 defective ext2 causes exostoses 2
- R-hsa-9918485 dengue virus attachment and entry
- R-hsa-9918481 dengue virus host interactions
- R-hsa-9839923 dengue virus infection
- R-hsa-3560782 diseases associated with glycosaminoglycan metabolism
- R-hsa-3781865 diseases of glycosylation
- R-hsa-5668914 diseases of metabolism
- R-hsa-9772572 early sars cov 2 infection events
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Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence38
Ligand-Receptor Signaling (35)
35 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor_regulator | receptor_regulator | OmniPath | Yes | No | Yes | No | No |
| glypican | ligand_regulator | HGNC | Yes | No | Yes | No | No |
| glypican | ligand_regulator | Matrisome | Yes | No | Yes | No | No |
| ligand_regulator | ligand_regulator | OmniPath | Yes | No | Yes | No | No |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | Yes | No | No |
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | Yes | No | No |
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | No | Yes | No | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | Yes | No | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | Yes | No | No |
| transmembrane | transmembrane | TopDB | No | No | Yes | No | No |
Regulatory Interaction Network (2)
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| GPC3 | P51654 | SHH | Q15465 | Yes | Yes | No | SignaLink3 | SignaLink3:18505598SignaLink3:23331499 |
| GPC3 | P51654 | DPP4 | P27487 | Yes | No | Yes | SIGNOR | SIGNOR:17549790 |
Sequence, Structure & Domains11
Sequences
Length
580
Mass
65,563
Sequence
MAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQVCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVRHAKNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYTQLMNPGLPDSALDINECLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINTTDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILSLEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNAGKLTTTIGKLCAHSQQRQYRSAYYPEDLFIDKKVLKVAHVEHEETLSSRRRELIQKLKSFISFYSALPGYICSHSPVAENDTLCWNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSMPKGRVLDKNLDEEGFESGDCGDDEDECIGGSGDGMIKVKNQLRFLAELAYDLDVDDAPGNSQQATPKDNEISTFHNLGNVHSPLKLLTSMAISVVCFFFLVH
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P51654-1; Sequence=Displayed; Name=2; Synonyms=Variant B; IsoId=P51654-2; Sequence=VSP_046117; Name=3; Synonyms=Variant C; IsoId=P51654-3; Sequence=VSP_046703
Alternative Sequence
59..112; Missing (in isoform 2); 344; T -> TETEKKIWHFKYPIFFLCIGLDLQ (in isoform 3)
3D Structural Models
Turn
205..210; 397..403
Helix
75..133; 135..137; 140..156; 163..181; 195..204; 211..243; 250..260; 262..265; 275..285; 287..290; 292..309; 316..321; 323..335; 338..348; 384..396; 405..411; 457..474
Beta Strand
63..65; 420..423; 425..431
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Protein Families
Glypican family
Sequence Similarities
Belongs to the glypican family.
Clinical Relevance4
Related Diseases (4)
Biomarker
Phase 2; Phase 1
Drug Targets
Clinical trial target
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No abstract available |