Protein detail
UB2D1
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Entry name UB2D1 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 2 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Protein Class (3)
EnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function (3)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (5)
E2(17)KB1SFTUBC4/5UBCH5UbcH5A
Gene Description
Ubiquitin conjugating enzyme E2 D1
Chromosome
10
Position
58334979-58370751
Supporting publications (n)
2
EVMP confidence score
0.38
Fluorescence & Localization5
Tissue Specificlymphoid tissueCell SpecificB-cellsSingle-Nuclei Brain SpecificleukocyteBlood Cell Specificmemory B-cellBlood Lineage SpecificB-cells
Function & Pathway8
Protein Function (3)
- ENZYME proteins:Transferases
- Enzymes
- Predicted intracellular proteins
Cellular Component (5)
Molecular Function (5)
Biological Process (3)
KEGG (4)
Reactome (69)
- R-hsa-9687136 aberrant regulation of mitotic exit in cancer due to rb1 defects
- R-hsa-176814 activation of apc c and apc c cdc20 mediated degradation of mitotic proteins
- R-hsa-1280218 adaptive immune system
- R-hsa-983168 antigen processing ubiquitination proteasome degradation
- R-hsa-179409 apc cdc20 mediated degradation of nek2a
- R-hsa-174048 apc c cdc20 mediated degradation of cyclin b
- R-hsa-174178 apc c cdh1 mediated degradation of cdc20 and other apc c cdh1 targeted proteins in late mitosis early g1
- R-hsa-174143 apc c mediated degradation of cell cycle proteins
- R-hsa-69017 cdk mediated phosphorylation and removal of cdc6
- R-hsa-8953897 cellular responses to stimuli
Page 1 of 7
Canonical Pathways (2)
- M44 Pid hif2pathway
- M255 Pid hif1 tfpathway
Mediation Categories (4)
Clinical-translation mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence36
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network (18)
18 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| SMUF2 | Q9HAU4 | UB2D1 | P51668 | Yes | Yes | No | HINTSIGNOR | HINT:24709419HINT:20858899HINT:32669362SIGNOR:24709419HINT:25723849 |
| UB2D1 | P51668 | ZSWM2 | Q8NEG5 | Yes | Yes | No | SIGNOR | SIGNOR:16522193 |
| PEX12 | O00623 | UB2D1 | P51668 | Yes | Yes | No | SIGNOR | SIGNOR:19687296 |
| COMPLEX:P22314_P62979 | UB2D1 | P51668 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P22314_P62987 | UB2D1 | P51668 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG47_P22314 | UB2D1 | P51668 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| COMPLEX:P0CG48_P22314 | UB2D1 | P51668 | Yes | Yes | No | SIGNOR | SIGNOR:34199813 | |
| UB2D1 | P51668 | COMPLEX:Q5XPI4_Q9BSL1 | Yes | Yes | No | SIGNOR | SIGNOR:15531880 |
Page 2 of 2Previous
Protein Complex Composition (12)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | R SequencingMass spectrometry | 1 | 27605433 |
Sequence, Structure & Domains10
Sequences
Length
147
Mass
16,602
Sequence
MALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDYPFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLVPDIAQIYKSDKEKYNRHAREWTQKYAM
3D Structural Models
Turn
44..47; 58..61; 90..92
Helix
1..15; 87..89; 99..111; 121..129; 131..146
Beta Strand
21..26; 29..38; 41..43; 49..55; 66..69; 115..117
3D Structure
X-ray crystallography (10)
Domain & Motif Annotations
Domain (FT)
1..147; UBC core
Protein Families
Ubiquitin-conjugating enzyme family
Sequence Similarities
Belongs to the ubiquitin-conjugating enzyme family.
Clinical Relevance5
Drugs
Antibody
Interaction Protein (34)
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
Interaction Count
34
Interaction Dataset
intact_biogrid
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 28396511 | Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker. | No abstract available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |