Protein detail
EMP2
Epithelial membrane protein 2 (EMP-2) (Protein XMP)
Entry name EMP2 | UniProt ID | EVMP confidence score 0.53 |
Supporting publications (n) 2 | Transmembrane count 4 | Protein classification Disease related genesHuman disease related genesPredicted membrane proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Epithelial membrane protein 2 (EMP-2) (Protein XMP)
Protein Class (3)
Disease related genesHuman disease related genesPredicted membrane proteins
Protein Function (2)
- Disease related genes
- Human disease related genes:Urinary system diseases:Kidney diseases
Transmembrane
1..21; Helical; 67..87; Helical; 95..115; Helical; 143..163; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
XMP
Gene Description
Epithelial membrane protein 2
Chromosome
16
Position
10528422-10580632
Supporting publications (n)
2
EVMP confidence score
0.53
Fluorescence & Localization
Function & Pathway
Protein Function (2)
- Disease related genes
- Human disease related genes:Urinary system diseases:Kidney diseases
Cellular Component (11)
- GO:0000139 Golgi membrane
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0016324 apical plasma membrane
- GO:0031410 cytoplasmic vesicle
- GO:0045177 apical part of cell
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Molecular Function (4)
Mediation Categories (4)
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence19
Ligand-Receptor Signaling (16)
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| transmembrane | transmembrane | UniProt_location | |||||
| transmembrane | transmembrane | UniProt_topology | |||||
| transmembrane | transmembrane | UniProt_keyword | |||||
| transmembrane | transmembrane | Ramilowski_location | |||||
| transmembrane | transmembrane | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location |
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Protein Complex Composition (2)
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster92 | KPNB1NEMP1NEMP2NXF1NXF2BNXF3NXT1NXT2RANBP2RGPD1RGPD2RGPD3RGPD4RGPD6RGPD8 | A6NFY4A6NKT7O14524O14715P0DJD0P0DJD1P49792Q14974Q7Z3J3Q99666Q9GZY0Q9H4D5Q9NPJ8Q9UBU9Q9UKK6 | 1:1:1:1:1:1:1:1:1:2:2:1:1:1:1 | Compleat | Compleat:HC577 | 22036573 |
| ATP13A3NEMP2RANRANGRFRGPD8 | A6NFY4O14715P62826Q9H7F0Q9HD47 | 0:0:0:0:0 | hu.MAP2 |
Sequence, Structure & Domains
Sequences
Length
167
Mass
19,199
Sequence
MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQEYSTLQAVQATMILSTILCCIAFFIFVLQLFRLKQGERFVLTSIIQLMSCLCVMIAASIYTDRREDIHDKNAKFYPVTREGSYGYSYILAWVAFACTFISGMMYLILRKRK
Domain & Motif Annotations
Protein Families
PMP-22/EMP/MP20 family
Sequence Similarities
Belongs to the PMP-22/EMP/MP20 family.
Clinical Relevance
Disease Involvement
Disease variant
Drugs (2)
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 27605433 | Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo. | No related sentences available |
| 28396511 | Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker. | No related sentences available |