Protein detail
EMP2
Epithelial membrane protein 2 (EMP-2) (Protein XMP)
Entry name EMP2 | UniProt ID | EVMP confidence score 0.25 |
Supporting publications (n) 2 | Transmembrane count 4 | Protein classification Disease related genesHuman disease related genesPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Epithelial membrane protein 2 (EMP-2) (Protein XMP)
Protein Class (3)
Disease related genesHuman disease related genesPredicted membrane proteins
Protein Function (2)
- Disease related genes
- Human disease related genes:Urinary system diseases:Kidney diseases
Transmembrane
1..21; Helical; 67..87; Helical; 95..115; Helical; 143..163; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Gene Synonym
XMP
Gene Description
Epithelial membrane protein 2
Chromosome
16
Position
10528422-10580632
Supporting publications (n)
2
EVMP confidence score
0.25
Fluorescence & Localization1
Function & Pathway5
Protein Function (2)
- Disease related genes
- Human disease related genes:Urinary system diseases:Kidney diseases
Cellular Component (11)
- GO:0000139 Golgi membrane
- GO:0005634 nucleus
- GO:0005737 cytoplasm
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0009986 cell surface
- GO:0016020 membrane
- GO:0016324 apical plasma membrane
- GO:0031410 cytoplasmic vesicle
- GO:0045177 apical part of cell
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Molecular Function (4)
Mediation Categories (4)
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence19
Ligand-Receptor Signaling (16)
16 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| apical_cell_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | No | No |
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
| plasma_membrane_regulator | plasma_membrane_regulator | Almen2009 | No | No | No | No | No |
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Protein Complex Composition (2)
2 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| HT_DM_Cluster92 | KPNB1NEMP1NEMP2NXF1NXF2BNXF3NXT1NXT2RANBP2RGPD1RGPD2RGPD3RGPD4RGPD6RGPD8 | A6NFY4A6NKT7O14524O14715P0DJD0P0DJD1P49792Q14974Q7Z3J3Q99666Q9GZY0Q9H4D5Q9NPJ8Q9UBU9Q9UKK6 | 1:1:1:1:1:1:1:1:1:2:2:1:1:1:1 | Compleat | Compleat:HC577 | 22036573 |
| ATP13A3NEMP2RANRANGRFRGPD8 | A6NFY4O14715P62826Q9H7F0Q9HD47 | 0:0:0:0:0 | hu.MAP2 |
Sequence, Structure & Domains5
Sequences
Length
167
Mass
19,199
Sequence
MLVLLAFIIAFHITSAALLFIATVDNAWWVGDEFFADVWRICTNNTNCTVINDSFQEYSTLQAVQATMILSTILCCIAFFIFVLQLFRLKQGERFVLTSIIQLMSCLCVMIAASIYTDRREDIHDKNAKFYPVTREGSYGYSYILAWVAFACTFISGMMYLILRKRK
Domain & Motif Annotations
Protein Families
PMP-22/EMP/MP20 family
Sequence Similarities
Belongs to the PMP-22/EMP/MP20 family.
Clinical Relevance3
Disease Involvement
Disease variant
Drugs (2)