Protein detail

CADH4

Cadherin-4 (Retinal cadherin) (R-CAD) (R-cadherin)

Protein symbol CADH4	UniProt ID P55283	EVMP score 0.50
Frequency 1	Transmembrane count 1	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Cadherin-4 (Retinal cadherin) (R-CAD) (R-cadherin)

Transmembrane

735..756; Helical

Transmembrane Count

Ensembl

ENSG00000179242

Entrez Gene Symbol

CDH4

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificBreast lactating cellsBlood Cell Specificintermediate monocyteBlood Lineage Specificmonocytes

Function & Pathway

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Canonical Pathways

M166 Pid atf2 pathway

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

34 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellChatDB	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	OmniPath	Yes	No	No	Yes	No
type1_classical_cadherin	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	HGNC	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No

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Regulatory Interaction Network

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PROF1	P07737	CADH4	P55283	Yes	Yes	No	SIGNOR	SIGNOR:22820501
DIAP1	O60610	CADH4	P55283	Yes	Yes	No	SIGNOR	SIGNOR:22820501
CADH4	P55283	CTNB1	P35222	Yes	Yes	No	SIGNOR	SIGNOR:21255999
CADH4	P55283	RAC1	P63000	Yes	Yes	No	SIGNOR	SIGNOR:18701479

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	ELISA	2	26775013 40784529

Sequence, Structure & Domains

Sequences

Length

916

Mass

100,281

Sequence

MTAGAGVLLLLLSLSGALRAHNEDLTTRETCKAGFSEDDYTALISQNILEGEKLLQVKFSSCVGTKGTQYETNSMDFKVGADGTVFATRELQVPSEQVAFTVTAWDSQTAEKWDAVVRLLVAQTSSPHSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNLNAINITAADADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNGDCTTIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPEAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPGDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWGPRFKKLADMYGGGEED

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P55283-1; Sequence=Displayed; Name=2; IsoId=P55283-2; Sequence=VSP_045548

Alternative Sequence

1..74; Missing (in isoform 2)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

129..138; Basic residues

Domain (CC)

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

Domain (FT)

170..277; Cadherin 1; 278..392; Cadherin 2; 393..507; Cadherin 3; 508..613; Cadherin 4; 614..724; Cadherin 5

Region

124..168; Disordered; 806..838; Disordered

Clinical Relevance

Drugs

ZIPRASIDONE