Protein detail

CADH4

Cadherin-4 (Retinal cadherin) (R-CAD) (R-cadherin)

Entry name CADH4	UniProt ID P55283	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information7

Protein Names

Cadherin-4 (Retinal cadherin) (R-CAD) (R-cadherin)

Transmembrane

735..756; Helical

Transmembrane Count

Ensembl

ENSG00000179242

Entrez Gene Symbol

CDH4

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Cell SpecificBreast lactating cellsBlood Cell Specificintermediate monocyteBlood Lineage Specificmonocytes

Function & Pathway7

Cellular Component (3)

Molecular Function (3)

Biological Process (3)

KEGG (2)

Reactome (4)

Canonical Pathways

M166 Pid atf2 pathway

Mediation Categories (3)

Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence39

Ligand-Receptor Signaling (34)

34 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
icam	cell_adhesion	Zhong2015	Yes	Yes	No	Yes	No
classical_cadherin	cell_adhesion	Almen2009	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Almen2009	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	HGNC	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	Yes	No

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Regulatory Interaction Network (4)

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PROF1	P07737	CADH4	P55283	Yes	Yes	No	SIGNOR	SIGNOR:22820501
DIAP1	O60610	CADH4	P55283	Yes	Yes	No	SIGNOR	SIGNOR:22820501
CADH4	P55283	CTNB1	P35222	Yes	Yes	No	SIGNOR	SIGNOR:21255999
CADH4	P55283	RAC1	P63000	Yes	Yes	No	SIGNOR	SIGNOR:18701479

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	ELISA	2	26775013 40784529

Sequence, Structure & Domains9

Sequences

Length

916

Mass

100,281

Sequence

MTAGAGVLLLLLSLSGALRAHNEDLTTRETCKAGFSEDDYTALISQNILEGEKLLQVKFSSCVGTKGTQYETNSMDFKVGADGTVFATRELQVPSEQVAFTVTAWDSQTAEKWDAVVRLLVAQTSSPHSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLPKEAQICEKPNLNAINITAADADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNGDCTTIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPEAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPGDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWGPRFKKLADMYGGGEED

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P55283-1; Sequence=Displayed; Name=2; IsoId=P55283-2; Sequence=VSP_045548

Alternative Sequence

1..74; Missing (in isoform 2)

Domain & Motif Annotations

Compositional Bias

129..138; Basic residues

Domain (CC)

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.

Domain (FT)

170..277; Cadherin 1; 278..392; Cadherin 2; 393..507; Cadherin 3; 508..613; Cadherin 4; 614..724; Cadherin 5

Region

124..168; Disordered; 806..838; Disordered

Clinical Relevance1

Drugs

ZIPRASIDONE

Supporting Publications1

PMID	Title	Abstract
37403840	Phosphoproteome analysis of cerebrospinal fluid extracellular vesicles in primary central nervous system lymphoma.	No abstract available