Protein detail
JAM2
Junctional adhesion molecule B (JAM-B) (Junctional adhesion molecule 2) (JAM-2) (Vascular endothelial junction-associated molecule) (VE-JAM) (CD antigen CD322)
Protein symbol JAM2 | UniProt ID | EVMP score 0.63 |
Frequency 6 | Transmembrane count 1 | Protein classification |
Basic Information
Protein Names
Junctional adhesion molecule B (JAM-B) (Junctional adhesion molecule 2) (JAM-2) (Vascular endothelial junction-associated molecule) (VE-JAM) (CD antigen CD322)
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- CD markers
Transmembrane
239..259; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
6
EVMP Score
0.63
Fluorescence & Localization
Cell SpecificCardiomyocytes
Function & Pathway
Protein Function
- Human disease related genes:Nervous system diseases:Neurodegenerative diseases
- Disease related genes
- CD markers
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Canonical Pathways
- M290 Pid il12 stat4 pathway
- M88 Pid cd8 tcr pathway
- M34 Pid tcr pathway
Mediation Categories
Fusion and delivery mediationImmune mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
41 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | LOCATE | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | connectomeDB2020 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellChatDB | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | Baccin2019 | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | CellPhoneDB | Yes | No | No | Yes | No |
| cell_surface_ligand | cell_surface_ligand | OmniPath | Yes | No | No | Yes | No |
| ig_like | cell_adhesion | HGNC | Yes | Yes | No | Yes | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
298
Mass
33,207
Sequence
MARRSRHRLLLLLLRYLVVALGYHKAYGFSAPKDQQVVTAVEYQEAILACKTPKKTVSSRLEWKKLGRSVSFVYYQQTLQGDFKNRAEMIDFNIRIKNVTRSDAGKYRCEVSAPSEQGQNLEEDTVTLEVLVAPAVPSCEVPSSALSGTVVELRCQDKEGNPAPEYTWFKDGIRLLENPRLGSQSTNSSYTMNTKTGTLQFNTVSKLDTGEYSCEARNSVGYRRCPGKRMQVDDLNISGIIAAVVVVALVISVCGLGVCYAQRKGYFSKETSFQKSNSSSKATTMSENDFKHTKSFII
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P57087-1; Sequence=Displayed; Name=2; IsoId=P57087-2; Sequence=VSP_045153; Name=3; IsoId=P57087-3; Sequence=VSP_047352
Alternative Sequence
44..79; Missing (in isoform 2); 289..298; DFKHTKSFII -> VQWLTPVIPALWKAAAGGSRGQEF (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Domain (CC)
The Ig-like V-type domain is necessary and sufficient to mediate interaction with JAM3 and integrin alpha-4/beta-1..
Domain (FT)
32..127; Ig-like V-type; 134..238; Ig-like C2-type
Protein Families
Immunoglobulin superfamily
Sequence Similarities
Belongs to the immunoglobulin superfamily.