Protein detail
RAB25
Ras-related protein Rab-25 (EC 3.6.5.2) (CATX-8)
Protein symbol RAB25 | UniProt ID | EVMP score 0.88 |
Frequency 37 | Transmembrane count | Protein classification Cancer-related genesPredicted intracellular proteins |
Basic Information
Protein Names
Ras-related protein Rab-25 (EC 3.6.5.2) (CATX-8)
Protein Class
Cancer-related genesPredicted intracellular proteins
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
CATX-8
Gene Description
RAB25, member RAS oncogene family
Chromosome
1
Position
156061160-156070504
Frequency
37
EVMP Score
0.88
Fluorescence & Localization
Function & Pathway
Protein Function
- Cancer-related genes:Candidate cancer biomarkers
- Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Canonical Pathways
- M69 Pid reelin pathway
- M163 Pid lis1 pathway
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
7 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
7 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| EVI5LRAB11ARAB11BRAB11FIP1RAB11FIP2RAB11FIP5RAB25SH3BP5 | O60239P57735P62491Q15907Q6WKZ4Q7L804Q96CN4Q9BXF6 | 0:0:0:0:0:0:0:0 | hu.MAP2 | |||
| RAB11BRAB11FIP1RAB11FIP2RAB11FIP5RAB25SH3BP5SH3BP5L | O60239P57735Q15907Q6WKZ4Q7L804Q7L8J4Q9BXF6 | 0:0:0:0:0:0:0 | hu.MAP | |||
| RAB11BRAB25SH3BP5SH3BP5L | O60239P57735Q15907Q7L8J4 | 0:0:0:0 | hu.MAP | |||
| CHMLD2HGDHPOTEGRAB1ARAB25RAB3ARAB3IL1RAB3IPRABAC1STX5UBCYIF1B | P0CG48P20336P26374P57735P62820Q13190Q5BJH7Q6S5H5Q8N465Q8TBN0Q96QF0Q9UI14 | 1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC4885 | ||
| D2HGDHGDI1RAB17RAB22ARAB25RAB33BRAB7ARABAC1TBC1D13UBCVPS33BYIF1BYIPF1YIPF5 | P0CG48P31150P51149P57735Q5BJH7Q8N465Q969M3Q9H082Q9H0T7Q9H267Q9NVG8Q9UI14Q9UL26Q9Y548 | 1:1:1:1:1:1:1:1:1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC9123 | ||
| RAB11ARAB11BRAB11FIP1RAB11FIP2RAB11FIP5RAB25 | P57735P62491Q15907Q6WKZ4Q7L804Q9BXF6 | 0:0:0:0:0:0 | hu.MAP2 | |||
| RAB11FIP2RAB25 | P57735Q7L804 | 2:2 | PDB | PDB:3tso |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| PRotein Organic Solvent Precipitation；Differential Ultracentrifugation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
213
Mass
23,496
Sequence
MGNGTEEDYNFVFKVVLIGESGVGKTNLLSRFTRNEFSHDSRTTIGVEFSTRTVMLGTAAVKAQIWDTAGLERYRAITSAYYRGAVGALLVFDLTKHQTYAVVERWLKELYDHAEATIVVMLVGNKSDLSQAREVPTEEARMFAENNGLLFLETSALDSTNVELAFETVLKEIFAKVSKQRQNSIRTNAITLGSAQAGQEPGPGEKRACCISL
3D Structural Models
Turn
156..158
Helix
25..34; 78..82; 97..101; 103..111; 127..132; 137..146; 162..177
Beta Strand
11..19; 46..56; 59..68; 87..93; 119..125; 150..153
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Motif
35..49; Switch 1; 67..84; Switch 2
Domain (CC)
Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.
Protein Families
- Small GTPase superfamily
- Rab family
Sequence Similarities
Belongs to the small GTPase superfamily. Rab family.