Protein detail

RAB25

Ras-related protein Rab-25 (EC 3.6.5.2) (CATX-8)

Entry name RAB25	UniProt ID P57735	EVMP confidence score 0.88
Supporting publications (n) 37	Transmembrane count	Protein classification Cancer-related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Ras-related protein Rab-25 (EC 3.6.5.2) (CATX-8)

Protein Class (2)

Cancer-related genesPredicted intracellular proteins

Protein Function (2)

Cancer-related genes:Candidate cancer biomarkers
Predicted intracellular proteins

Ensembl

ENSG00000132698

Entrez Gene Symbol

RAB25

Gene Synonym

CATX-8

Gene Description

RAB25, member RAS oncogene family

Chromosome

Position

156061160-156070504

Supporting publications (n)

EVMP confidence score

0.88

Fluorescence & Localization1

Function & Pathway7

Protein Function (2)

Cancer-related genes:Candidate cancer biomarkers
Predicted intracellular proteins

Cellular Component (7)

Molecular Function (4)

Biological Process (3)

Reactome (2)

Canonical Pathways (2)

M69 Pid reelin pathway
M163 Pid lis1 pathway

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence15

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

Protein Complex Composition (7)

7 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
EVI5L RAB11A RAB11B RAB11FIP1 RAB11FIP2 RAB11FIP5 RAB25 SH3BP5	O60239 P57735 P62491 Q15907 Q6WKZ4 Q7L804 Q96CN4 Q9BXF6	0:0:0:0:0:0:0:0	hu.MAP2
RAB11B RAB11FIP1 RAB11FIP2 RAB11FIP5 RAB25 SH3BP5 SH3BP5L	O60239 P57735 Q15907 Q6WKZ4 Q7L804 Q7L8J4 Q9BXF6	0:0:0:0:0:0:0	hu.MAP
RAB11B RAB25 SH3BP5 SH3BP5L	O60239 P57735 Q15907 Q7L8J4	0:0:0:0	hu.MAP
CHML D2HGDH POTEG RAB1A RAB25 RAB3A RAB3IL1 RAB3IP RABAC1 STX5 UBC YIF1B	P0CG48 P20336 P26374 P57735 P62820 Q13190 Q5BJH7 Q6S5H5 Q8N465 Q8TBN0 Q96QF0 Q9UI14	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4885
D2HGDH GDI1 RAB17 RAB22A RAB25 RAB33B RAB7A RABAC1 TBC1D13 UBC VPS33B YIF1B YIPF1 YIPF5	P0CG48 P31150 P51149 P57735 Q5BJH7 Q8N465 Q969M3 Q9H082 Q9H0T7 Q9H267 Q9NVG8 Q9UI14 Q9UL26 Q9Y548	1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC9123
RAB11A RAB11B RAB11FIP1 RAB11FIP2 RAB11FIP5 RAB25	P57735 P62491 Q15907 Q6WKZ4 Q7L804 Q9BXF6	0:0:0:0:0:0	hu.MAP2
RAB11FIP2 RAB25	P57735 Q7L804	2:2	PDB	PDB:3tso

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
PRotein Organic Solvent Precipitation；Differential Ultracentrifugation	Mass spectrometry	1	32384937

Sequence, Structure & Domains11

Sequences

Length

213

Mass

23,496

Sequence

MGNGTEEDYNFVFKVVLIGESGVGKTNLLSRFTRNEFSHDSRTTIGVEFSTRTVMLGTAAVKAQIWDTAGLERYRAITSAYYRGAVGALLVFDLTKHQTYAVVERWLKELYDHAEATIVVMLVGNKSDLSQAREVPTEEARMFAENNGLLFLETSALDSTNVELAFETVLKEIFAKVSKQRQNSIRTNAITLGSAQAGQEPGPGEKRACCISL

3D Structural Models

Turn

156..158

Helix

25..34; 78..82; 97..101; 103..111; 127..132; 137..146; 162..177

Beta Strand

11..19; 46..56; 59..68; 87..93; 119..125; 150..153

3D Structure

X-ray crystallography (2)

Domain & Motif Annotations

Motif

35..49; Switch 1; 67..84; Switch 2

Domain (CC)

Switch 1, switch 2 and the interswitch regions are characteristic of Rab GTPases and mediate the interactions with Rab downstream effectors. The switch regions undergo conformational changes upon nucleotide binding which drive interaction with specific sets of effector proteins, with most effectors only binding to GTP-bound Rab.

Protein Families (2)

Small GTPase superfamily
Rab family

Sequence Similarities

Belongs to the small GTPase superfamily. Rab family.

Clinical Relevance5

Disease Involvement

Cancer-related genes

Antibody (2)

HPA010940 CAB033645

Interaction Protein (2)

ENSG00000107560ENSG00000175137

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications37

PMID	Title	Abstract
30071318	Changes in the urinary extracellular vesicle proteome are associated with nephronophthisis-related ciliopathies.	No abstract available
30608700	Quantitative Proteomic Analysis of Small and Large Extracellular Vesicles (EVs) Reveals Enrichment of Adhesion Proteins in Small EVs.	No abstract available
30760538	Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection.	No abstract available
31366407	Proteomic and histopathological characterisation of sicca subjects and primary Sjögren's syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers.	No abstract available
31508500	Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping.	No abstract available
31685984	Tumour exosomal CEMIP protein promotes cancer cell colonization in brain metastasis.	Proteomic analysis identified cell migration-inducing and hyaluronan-binding protein (CEMIP) as elevated in exosomes from brain metastatic but not lung or bone metastatic cells.
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
32927759	Urinary Exosomes of Patients with Cystic Fibrosis Unravel CFTR-Related Renal Disease.	No abstract available
33114768	Proteomic Profiling of Two Distinct Populations of Extracellular Vesicles Isolated from Human Seminal Plasma.	No abstract available
33580265	Proteomic Profile of Urinary Extracellular Vesicles Identifies AGP1 as a Potential Biomarker of Primary Aldosteronism.	No abstract available

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