Protein detail
DEST
Destrin (Actin-depolymerizing factor) (ADF)
Protein symbol DEST | UniProt ID | EVMP score 0.75 |
Frequency 30 | Transmembrane count | Protein classification Plasma proteinsPredicted intracellular proteins |
Basic Information
Protein Names
Destrin (Actin-depolymerizing factor) (ADF)
Protein Class
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
ACTDPADF
Gene Description
Destrin, actin depolymerizing factor
Chromosome
20
Position
17570075-17609919
Frequency
30
EVMP Score
0.75
Fluorescence & Localization
Tissue SpecificbrainCell SpecificDifferentiating spermatogoniaBlood Cell SpecificT-reg
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Fusion and delivery mediation
Relations & Evidence
Enzyme-Mediated Modification
5 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| DSTN | TESK2 | Q96S53 | S | 3 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperHPRDKEASIGNOR_ProtMapper | HPRD:19413330HPRD:11418599HPRD:19651622ProtMapper:11418599HPRD:20068231KEA:11418599 |
| DSTN | SSH1 | Q8WYL5 | S | 3 | dephosphorylation | DEPOD | DEPOD:11832213 |
| DSTN | LIMK2 | P53671 | S | 3 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| DSTN | LIMK1 | P53667 | S | 3 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| DSTN | TESK1 | Q15569 | S | 3 | phosphorylation | PhosphoSite |
Ligand-Receptor Signaling
3 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TESK2 | Q96S53 | DEST | P60981 | Yes | No | Yes | PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | HPRD:11418599HPRD-phos:11418599ProtMapper:11418599ProtMapper:19651622ProtMapper:20068231HPRD-phos:20068231KEA:11418599HPRD-phos:19413330SIGNOR:11418599HPRD-phos:19651622ProtMapper:19413330 |
| LIMK2 | P53671 | DEST | P60981 | Yes | No | No | PhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperACSNPhosphoSitePhosphoSite_ProtMapper | ACSN:11340065PhosphoSite:7615564ACSN:10613909ACSN:10559936ACSN:11950587ACSN:11413130ACSN:10461188 |
Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| COX17DSTNHAAOPIN1 | P46952P60981Q13526Q14061 | 0:0:0:0 | hu.MAP2 | |||
| DSTNGCNT4PCBD1TSTD1 | P60981P61457Q8NFU3Q9P109 | 0:0:0:0 | hu.MAP2 | |||
| CROTDPP3DSTNLIMD1MDP1MYG1NMIOTULINPIEZO1 | P60981Q13287Q86V88Q92508Q96BN8Q9HB07Q9NY33Q9UGP4Q9UKG9 | 0:0:0:0:0:0:0:0:0 | Havugimana2012 | Havugimana2012:C_568 | ||
| COX17DSTN | P60981Q14061 | 0:0 | hu.MAP2 | |||
| ADSS1DSTN | P60981Q8N142 | 0:0 | hu.MAP2 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 31414377 |
Sequence, Structure & Domains
Sequences
Length
165
Mass
18,506
Sequence
MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDVGVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASSKDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P60981-1; Sequence=Displayed; Name=2; IsoId=P60981-2; Sequence=VSP_043069
Alternative Sequence
1..17; Missing (in isoform 2)
3D Structural Models
Domain & Motif Annotations
Motif
30..34; Nuclear localization signal
Domain (FT)
4..153; ADF-H
Protein Families
Actin-binding proteins ADF family
Sequence Similarities
Belongs to the actin-binding proteins ADF family.