Protein detail

DEST

Destrin (Actin-depolymerizing factor) (ADF)

Entry name
DEST
UniProt ID
P60981
EVMP confidence score
0.88
Supporting publications (n)
30
Transmembrane count
Protein classification
Plasma proteinsPredicted intracellular proteins
Basic Information
Protein Names
Destrin (Actin-depolymerizing factor) (ADF)
Protein Class (2)
Plasma proteinsPredicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
ENSG00000125868
Entrez Gene Symbol
DSTN
Gene Synonym (2)
ACTDPADF
Gene Description
Destrin, actin depolymerizing factor
Chromosome
20
Position
17570075-17609919
Supporting publications (n)
30
EVMP confidence score
0.88
Fluorescence & Localization
Tissue SpecificbrainCell SpecificDifferentiating spermatogoniaBlood Cell SpecificT-reg
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (7)
Molecular Function (2)
Biological Process (3)
Mediation Categories
Fusion and delivery mediation
Relations & Evidence16

Enzyme-Mediated Modification (5)

5 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
DSTNTESK2Q96S53S3phosphorylationPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperHPRDKEASIGNOR_ProtMapperHPRD:19413330HPRD:11418599HPRD:19651622ProtMapper:11418599HPRD:20068231KEA:11418599
DSTNSSH1Q8WYL5S3dephosphorylationDEPODDEPOD:11832213
DSTNLIMK2P53671S3phosphorylationPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
DSTNLIMK1P53667S3phosphorylationPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
DSTNTESK1Q15569S3phosphorylationPhosphoSite

Ligand-Receptor Signaling (3)

3 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularComPPI
intracellularintracellularGO_Intercell
intracellularintracellularOmniPath

Regulatory Interaction Network (2)

2 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
TESK2Q96S53DESTP60981YesYesPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDKEAHPRD_KEASIGNOR_ProtMapperHPRD-phosHPRD:11418599HPRD-phos:11418599ProtMapper:11418599ProtMapper:19651622ProtMapper:20068231HPRD-phos:20068231KEA:11418599HPRD-phos:19413330SIGNOR:11418599HPRD-phos:19651622ProtMapper:19413330
LIMK2P53671DESTP60981YesPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperACSNPhosphoSitePhosphoSite_ProtMapperACSN:11340065PhosphoSite:7615564ACSN:10613909ACSN:10559936ACSN:11950587ACSN:11413130ACSN:10461188

Protein Complex Composition (5)

5 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
COX17DSTNHAAOPIN1P46952P60981Q13526Q140610:0:0:0hu.MAP2
DSTNGCNT4PCBD1TSTD1P60981P61457Q8NFU3Q9P1090:0:0:0hu.MAP2
CROTDPP3DSTNLIMD1MDP1MYG1NMIOTULINPIEZO1P60981Q13287Q86V88Q92508Q96BN8Q9HB07Q9NY33Q9UGP4Q9UKG90:0:0:0:0:0:0:0:0Havugimana2012Havugimana2012:C_568
COX17DSTNP60981Q140610:0hu.MAP2
ADSS1DSTNP60981Q8N1420:0hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Size Exclusion ChromatographyMass spectrometry131414377
Sequence, Structure & Domains

Sequences

Length
165
Mass
18,506
Sequence
MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDVGVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASSKDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P60981-1; Sequence=Displayed; Name=2; IsoId=P60981-2; Sequence=VSP_043069
Alternative Sequence
1..17; Missing (in isoform 2)

Domain & Motif Annotations

Motif
30..34; Nuclear localization signal
Domain (FT)
4..153; ADF-H
Protein Families
Actin-binding proteins ADF family
Sequence Similarities
Belongs to the actin-binding proteins ADF family.
Clinical Relevance
Antibody (2)
CAB037094HPA077782
Interaction Protein (4)
ENSG00000001626ENSG00000075624ENSG00000165410ENSG00000184009
Interaction Count
4
Interaction Dataset (2)
intact_biogridintact_biogrid_opencell
Supporting Publications30
PMIDTitleRelated sentences
34064677Ubiquinone Metabolism and Transcription HIF-1 Targets Pathway Are Toxicity Signature Pathways Present in Extracellular Vesicles of Paraquat-Exposed Human Brain Microvascular Endothelial Cells.No related sentences available
34473505Column-based Technology for CD9-HPLC Immunoaffinity Isolation of Serum Extracellular Vesicles.Column-based Technology for CD9-HPLC Immunoaffinity Isolation of Serum Extracellular Vesicles.
34576246Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators.No related sentences available
36064647Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.No related sentences available
36146834Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.No related sentences available
36497184Oxidative Stress and Extracellular Matrix Remodeling Are Signature Pathways of Extracellular Vesicles Released upon Morphine Exposure on Human Brain Microvascular Endothelial Cells.No related sentences available
37204515Proteomic profiling and functional characterization of serum-derived extracellular vesicles in the mucinous and non-mucinous colon adenocarcinoma.No related sentences available
37322475Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.No related sentences available
37438638Extracellular Vesicles Play a Central Role in Cerebral Venous Disease-Associated Brain Atrophy.No related sentences available
37926756Extracellular vesicles from non-neuroendocrine SCLC cells promote adhesion and survival of neuroendocrine SCLC cells.No related sentences available
Page 2 of 3PreviousNext