Protein detail

TSN5

Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)

Protein symbol TSN5	UniProt ID P62079	EVMP score 0.50
Frequency 4	Transmembrane count 4	Protein classification

Basic Information

Protein Names

Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)

Transmembrane

18..38; Helical; 62..82; Helical; 93..113; Helical; 233..253; Helical

Transmembrane Count

Ensembl

ENSG00000168785

Entrez Gene Symbol

TSPAN5

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificsmooth muscleCell SpecificAlveolar cells type 1

Function & Pathway

Cellular Component

Molecular Function

Biological Process

Reactome

R-hsa-977225 amyloid fiber formation

Mediation Categories

Clinical-translation mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

21 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
adhesion	adhesion	MCAM	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	Cellinker	Yes	Yes	No	Yes	No
adhesion	adhesion	OmniPath	Yes	Yes	No	Yes	No
cell_adhesion	cell_adhesion	OmniPath	Yes	Yes	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
IMMP1L KLHL2 TMEM248 TSPAN5	O95198 P62079 Q96LU5 Q9NWD8	0:0:0:0	hu.MAP
NAT8L TSPAN5	P62079 Q8N9F0	0:0	hu.MAP2
IMMP1L NAT8L TMEM248 TSPAN5	P62079 Q8N9F0 Q96LU5 Q9NWD8	0:0:0:0	hu.MAP
IMMP1L PIEZO1 TMEM248 TSPAN5	P62079 Q92508 Q96LU5 Q9NWD8	0:0:0:0	hu.MAP
IMMP1L SNX25 TMEM248 TSPAN5	P62079 Q96LU5 Q9H3E2 Q9NWD8	0:0:0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	30646616 32089743

Sequence, Structure & Domains

Sequences

Length

268

Mass

30,337

Sequence

MSGKHYKGPEVSCCIKYFIFGFNVIFWFLGITFLGIGLWAWNEKGVLSNISSITDLGGFDPVWLFLVVGGVMFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVRASW

3D Structural Models

Domain & Motif Annotations

Protein Families

Tetraspanin (TM4SF) family

Sequence Similarities

Belongs to the tetraspanin (TM4SF) family.

Clinical Relevance

Drug Targets

Literature-reported target

Drugs

SEROTONIN

Interaction Protein

ENSG00000137845

Interaction Count

Interaction Dataset

intact_biogrid