Protein detail

TSN5

Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)

Protein symbol TSN5	UniProt ID P62079	EVMP score 0.50
Frequency 4	Transmembrane count 4	Protein classification

Basic Information

Protein Names

Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)

Transmembrane

18..38; Helical; 62..82; Helical; 93..113; Helical; 233..253; Helical

Transmembrane Count

Ensembl

ENSG00000168785

Entrez Gene Symbol

TSPAN5

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue Specificsmooth muscleCell SpecificAlveolar cells type 1

Function & Pathway

Cellular Component

Molecular Function

Biological Process

Reactome

R-hsa-977225 amyloid fiber formation

Mediation Categories

Clinical-translation mediationMetabolism mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

21 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
IMMP1L KLHL2 TMEM248 TSPAN5	O95198 P62079 Q96LU5 Q9NWD8	0:0:0:0	hu.MAP
NAT8L TSPAN5	P62079 Q8N9F0	0:0	hu.MAP2
IMMP1L NAT8L TMEM248 TSPAN5	P62079 Q8N9F0 Q96LU5 Q9NWD8	0:0:0:0	hu.MAP
IMMP1L PIEZO1 TMEM248 TSPAN5	P62079 Q92508 Q96LU5 Q9NWD8	0:0:0:0	hu.MAP
IMMP1L SNX25 TMEM248 TSPAN5	P62079 Q96LU5 Q9H3E2 Q9NWD8	0:0:0:0	hu.MAP

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	30646616 32089743

Sequence, Structure & Domains

Sequences

Length

268

Mass

30,337

Sequence

MSGKHYKGPEVSCCIKYFIFGFNVIFWFLGITFLGIGLWAWNEKGVLSNISSITDLGGFDPVWLFLVVGGVMFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVRASW

3D Structural Models

Domain & Motif Annotations

Protein Families

Tetraspanin (TM4SF) family

Sequence Similarities

Belongs to the tetraspanin (TM4SF) family.

Clinical Relevance

Drug Targets

Literature-reported target

Drugs

SEROTONIN

Interaction Protein

ENSG00000137845

Interaction Count

Interaction Dataset

intact_biogrid