Protein detail
TSN5
Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)
Entry name TSN5 | UniProt ID | EVMP confidence score 0.28 |
Supporting publications (n) 4 | Transmembrane count 4 | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)
Transmembrane
18..38; Helical; 62..82; Helical; 93..113; Helical; 233..253; Helical
Transmembrane Count
4
Ensembl
Entrez Gene Symbol
Supporting publications (n)
4
EVMP confidence score
0.28
Fluorescence & Localization
Tissue Specificsmooth muscleCell SpecificAlveolar cells type 1
Function & Pathway
Cellular Component (4)
Molecular Function (2)
Biological Process (3)
Mediation Categories (2)
Clinical-translation mediationMetabolism mediation
Relations & Evidence27
Ligand-Receptor Signaling (21)
21 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | Yes |
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Protein Complex Composition (5)
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| IMMP1LKLHL2TMEM248TSPAN5 | O95198P62079Q96LU5Q9NWD8 | 0:0:0:0 | hu.MAP | |||
| NAT8LTSPAN5 | P62079Q8N9F0 | 0:0 | hu.MAP2 | |||
| IMMP1LNAT8LTMEM248TSPAN5 | P62079Q8N9F0Q96LU5Q9NWD8 | 0:0:0:0 | hu.MAP | |||
| IMMP1LPIEZO1TMEM248TSPAN5 | P62079Q92508Q96LU5Q9NWD8 | 0:0:0:0 | hu.MAP | |||
| IMMP1LSNX25TMEM248TSPAN5 | P62079Q96LU5Q9H3E2Q9NWD8 | 0:0:0:0 | hu.MAP |
Sequence, Structure & Domains
Sequences
Length
268
Mass
30,337
Sequence
MSGKHYKGPEVSCCIKYFIFGFNVIFWFLGITFLGIGLWAWNEKGVLSNISSITDLGGFDPVWLFLVVGGVMFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVRASW
Domain & Motif Annotations
Protein Families
Tetraspanin (TM4SF) family
Sequence Similarities
Belongs to the tetraspanin (TM4SF) family.
Clinical Relevance
Drug Targets
Literature-reported target
Drugs
Interaction Protein
ENSG00000137845
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications4
| PMID | Title | Related sentences |
|---|---|---|
| 24505114 | Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform. | These included proteins of known association with cancer exosomes such as MFG-E8, integrins, and MET, and also those less widely reported as exosomally associated, such as ROR1 and ITIH4. |
| 31588238 | Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment. | No related sentences available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No related sentences available |
| 41233846 | Inflammation-related proteomics of extracellular vesicles as novel biomarkers for systemic lupus erythematosus revealed by proximity extension assay. | No related sentences available |