Protein detail

TSN5

Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)

Entry name TSN5	UniProt ID P62079	EVMP confidence score 0.50
Supporting publications (n) 4	Transmembrane count 4	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information7

Protein Names

Tetraspanin-5 (Tspan-5) (Tetraspan NET-4) (Transmembrane 4 superfamily member 9)

Transmembrane

18..38; Helical; 62..82; Helical; 93..113; Helical; 233..253; Helical

Transmembrane Count

Ensembl

ENSG00000168785

Entrez Gene Symbol

TSPAN5

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization2

Tissue Specificsmooth muscleCell SpecificAlveolar cells type 1

Function & Pathway5

Cellular Component (4)

Molecular Function (2)

Biological Process (3)

Reactome

R-hsa-977225 amyloid fiber formation

Mediation Categories (2)

Clinical-translation mediationMetabolism mediation

Relations & Evidence27

Ligand-Receptor Signaling (21)

21 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Protein Complex Composition (5)

5 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database
IMMP1L KLHL2 TMEM248 TSPAN5	O95198 P62079 Q96LU5 Q9NWD8	0:0:0:0	hu.MAP
NAT8L TSPAN5	P62079 Q8N9F0	0:0	hu.MAP2
IMMP1L NAT8L TMEM248 TSPAN5	P62079 Q8N9F0 Q96LU5 Q9NWD8	0:0:0:0	hu.MAP
IMMP1L PIEZO1 TMEM248 TSPAN5	P62079 Q92508 Q96LU5 Q9NWD8	0:0:0:0	hu.MAP
IMMP1L SNX25 TMEM248 TSPAN5	P62079 Q96LU5 Q9H3E2 Q9NWD8	0:0:0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	30646616 32089743

Sequence, Structure & Domains5

Sequences

Length

268

Mass

30,337

Sequence

MSGKHYKGPEVSCCIKYFIFGFNVIFWFLGITFLGIGLWAWNEKGVLSNISSITDLGGFDPVWLFLVVGGVMFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVRASW

Domain & Motif Annotations

Protein Families

Tetraspanin (TM4SF) family

Sequence Similarities

Belongs to the tetraspanin (TM4SF) family.

Clinical Relevance5

Drug Targets

Literature-reported target

Drugs

SEROTONIN

Interaction Protein

ENSG00000137845

Interaction Count

Interaction Dataset

intact_biogrid

Supporting Publications4

PMID	Title	Abstract
24505114	Proteomics analysis of cancer exosomes using a novel modified aptamer-based array (SOMAscan™) platform.	These included proteins of known association with cancer exosomes such as MFG-E8, integrins, and MET, and also those less widely reported as exosomally associated, such as ROR1 and ITIH4.
31588238	Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available
41233846	Inflammation-related proteomics of extracellular vesicles as novel biomarkers for systemic lupus erythematosus revealed by proximity extension assay.	No abstract available