Protein detail
EM55
55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1)
Entry name EM55 | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 17 | Transmembrane count | Protein classification Predicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1)
Protein Class
Predicted intracellular proteins
Protein Function
Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
DXS552EPEMP
Gene Description
MAGUK p55 scaffold protein 1
Chromosome
X
Position
154778684-154821007
Supporting publications (n)
17
EVMP confidence score
0.60
Fluorescence & Localization
Tissue Specificbone marrowCell SpecificNeutrophil progenitorsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificneutrophilBlood Lineage SpecificB-cells
Function & Pathway
Protein Function
Predicted intracellular proteins
Cellular Component (6)
Molecular Function (3)
Biological Process (3)
Reactome (3)
Canonical Pathways (3)
- M267 Pid anthrax pathway
- M69 Pid reelin pathway
- M12705 Sig cd40pathwaymap
Mediation Categories (2)
Fusion and delivery mediationImmune mediation
Relations & Evidence9
Ligand-Receptor Signaling (6)
6 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath |
Protein Complex Composition (2)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| PRotein Organic Solvent Precipitation；Differential Ultracentrifugation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
466
Mass
52,296
Sequence
MTLKASEGESGGSMHTALSDLYLEHLLQKRSRPEAVSHPLNTVTEDMYTNGSPAPGSPAQVKGQEVRKVRLIQFEKVTEEPMGITLKLNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKETKGMISLKVIPNQQSRLPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDSNWWQGRVEGSSKESAGLIPSPELQEWRVASMAQSAPSEAPSCSPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTDQGTQTEALQQLQKDSEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWVY
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q00013-1; Sequence=Displayed; Name=2; IsoId=Q00013-2; Sequence=VSP_042675; Name=3; IsoId=Q00013-3; Sequence=VSP_044634
Alternative Sequence
1..34; MTLKASEGESGGSMHTALSDLYLEHLLQKRSRPE -> MESW (in isoform 2); 161..180; Missing (in isoform 3)
3D Structural Models
Turn
125..127; 307..309; 391..393
Helix
104..108; 131..139; 295..305; 336..344; 363..371; 382..384; 385..388; 410..426; 427..429; 439..452
Beta Strand
70..76; 78..80; 83..88; 94..99; 101..103; 116..120; 142..149; 284..288; 348..354; 357..362; 375..379; 395..402; 405..407; 431..437
3D Structure
NMR spectroscopy (2); X-ray crystallography (1)
Domain & Motif Annotations
Domain (FT)
71..152; PDZ; 158..228; SH3; 282..451; Guanylate kinase-like
Region
268..466; Interaction with PALS1
Protein Families
MAGUK family
Sequence Similarities
Belongs to the MAGUK family.
Clinical Relevance
Antibody
Interaction Protein (2)
ENSG00000123240ENSG00000125257
Interaction Count
2
Interaction Dataset
intact_biogrid
Supporting Publications17
| PMID | Title | Related sentences |
|---|---|---|
| 38014595 | Proteome and immune responses of extracellular vesicles derived from macrophages infected with the periodontal pathogen Tannerella forsythia. | No related sentences available |
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No related sentences available |
| 38716512 | Assessment of urine sample collection and processing variables for extracellular vesicle-based proteomics. | No related sentences available |
| 40730843 | Single urinary extracellular vesicle proteomics identifies complement receptor CD35 as a biomarker for sepsis-associated acute kidney injury. | No related sentences available |
| 40840701 | Multiomics analysis to evaluate the enrichment of extracellular vesicles from human plasma. | No related sentences available |
| 41068253 | Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression. | No related sentences available |
| 41307968 | Extracellular Vesicles Define Discrete Nano-Based Niches Within the Human Haematopoietic System. | No related sentences available |
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