Protein detail

SCN7A

Sodium channel protein type 7 subunit alpha (Atypical sodium channel Nav2.1) (Nax channel) (Sodium channel protein type VII subunit alpha)

Protein symbol SCN7A	UniProt ID Q01118	EVMP score 0.50
Frequency 5	Transmembrane count 24	Protein classification FDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Basic Information

Protein Names

Sodium channel protein type 7 subunit alpha (Atypical sodium channel Nav2.1) (Nax channel) (Sodium channel protein type VII subunit alpha)

Protein Class

FDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function

FDA approved drug targets:Small molecule drugs
Predicted intracellular proteins

Transmembrane

118..137; Helical; Name=S1 of repeat I; 142..167; Helical; Name=S2 of repeat I; 179..196; Helical; Name=S3 of repeat I; 201..219; Helical; Name=S4 of repeat I; 238..259; Helical; Name=S5 of repeat I; 368..407; Helical; Name=S6 of repeat I; 506..521; Helical; Name=S1 of repeat II; 531..559; Helical; Name=S2 of repeat II; 569..586; Helical; Name=S3 of repeat II; 593..609; Helical; Name=S4 of repeat II; 627..655; Helical; Name=S5 of repeat II; 702..732; Helical; Name=S6 of repeat II; 935..953; Helical; Name=S1 of repeat III; 962..990; Helical; Name=S2 of repeat III; 999..1020; Helical; Name=S3 of repeat III; 1022..1040; Helical; Name=S4 of repeat III; 1056..1080; Helical; Name=S5 of repeat III; 1168..1202; Helical; Name=S6 of repeat III; 1251..1272; Helical; Name=S1 of repeat IV; 1277..1305; Helical; Name=S2 of repeat IV; 1313..1338; Helical; Name=S3 of repeat IV; 1342..1362; Helical; Name=S4 of repeat IV; 1378..1402; Helical; Name=S5 of repeat IV; 1469..1504; Helical; Name=S6 of repeat IV

Transmembrane Count

Ensembl

ENSG00000136546

Entrez Gene Symbol

SCN7A

Gene Synonym

NaGNav2.1Nav2.2SCN6A

Gene Description

Sodium voltage-gated channel alpha subunit 7

Chromosome

Position

166403573-166611482

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Protein Function

FDA approved drug targets:Small molecule drugs
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04261 Adrenergic signaling in cardiomyocytes

Reactome

Canonical Pathways

M190 Pid tcr jnk pathway
M20 Pid p38 mkk3 6pathway
M257 Pid ephrinb rev pathway

Mediation Categories

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

29 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
voltage_gated	ion_channel	Almen2009	No	Yes	No	No	No
voltage_gated	ion_channel	Surfaceome	No	Yes	No	No	No
transporter	transporter	OmniPath	No	Yes	No	No	No
ion_channel	ion_channel	OmniPath	No	Yes	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	GO_Intercell	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No

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Regulatory Interaction Network

0 records.

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	37588411

Sequence, Structure & Domains

Sequences

Length

1,682

Mass

193,493

Sequence

MLASPEPKGLVPFTKESFELIKQHIAKTHNEDHEEEDLKPTPDLEVGKKLPFIYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDGDRDVHATKEGAYFDKAKEKSPIQSQI

3D Structural Models

Turn

175..177; 217..219; 292..294; 956..960; 1021..1023; 1090..1092; 1098..1100; 1306..1311; 1447..1449

Helix

106..115; 118..135; 144..166; 179..195; 202..210; 211..216; 221..236; 238..259; 262..264; 286..288; 330..332; 341..350; 355..365; 368..370; 371..381; 384..403; 508..523; 532..558; 561..564; 568..584; 596..609; 611..655; 657..659; 674..685; 691..699; 702..732; 922..932; 934..949; 950..953; 962..990; 992..996; 999..1016; 1024..1035; 1036..1040; 1042..1055; 1056..1058; 1059..1080; 1104..1108; 1128..1139; 1144..1151; 1167..1169; 1170..1179; 1182..1203; 1212..1224; 1246..1249; 1251..1268; 1277..1304; 1313..1334; 1344..1350; 1351..1357; 1364..1402; 1420..1431; 1436..1443; 1444..1446; 1469..1502

Beta Strand

170..174; 265..270; 320..324; 585..590; 1086..1088; 1111..1113; 1117..1119; 1156..1159; 1208..1210; 1272..1274; 1358..1362; 1413..1419

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Compositional Bias

804..819; Basic and acidic residues; 820..834; Polar residues

Repeat

100..401; I; 487..758; II; 916..1224; III; 1233..1531; IV

Domain (CC)

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

Region

801..871; Disordered

Protein Families

Sodium channel (TC 1.A.1.10) family
SCN7A subfamily

Sequence Similarities

Belongs to the sodium channel (TC 1.A.1.10) family. SCN7A subfamily.

Clinical Relevance

Disease Involvement

FDA approved drug targets

Drug Targets

FDA approved drug targets

Drugs

DRONEDARONE HYDROCHLORIDE ORPHENADRINE HYDROCHLORIDE TOCAINIDE HYDROCHLORIDE EVENAMIDE ETHOTOIN MEPIVACAINE HYDROCHLORIDE ETIDOCAINE HYDROCHLORIDE RUFINAMIDE PROPOXYCAINE HYDROCHLORIDE CENOBAMATE DISOPYRAMIDE PHOSPHATE MEPHENYTOIN PROCAINE HYDROCHLORIDE RALFINAMIDE ESLICARBAZEPINE ACETATE CHLOROPROCAINE QUINIDINE SULFATE ZONISAMIDE SAFINAMIDE NERISPIRDINE TETRACAINE PROPAFENONE HYDROCHLORIDE PROPARACAINE HYDROCHLORIDE INDECAINIDE HYDROCHLORIDE RILUZOLE PRILOCAINE PROCAINAMIDE HYDROCHLORIDE TOPIRAMATE PRIMIDONE ESLICARBAZEPINE MERETHOXYLLINE PROCAINE COCAINE HYDROCHLORIDE PRILOCAINE HYDROCHLORIDE PHENYTOIN SODIUM OXCARBAZEPINE LIDOCAINE HYDROCHLORIDE LIDOCAINE IRAMPANEL DICHLOROBENZYL ALCOHOL PHENAZOPYRIDINE HYDROCHLORIDE QUINIDINE GLUCONATE DYCLONINE HYDROCHLORIDE ORPHENADRINE CITRATE QUINIDINE POLYGALACTURONATE MEXILETINE HYDROCHLORIDE ENCAINIDE HYDROCHLORIDE PHENACEMIDE ARTICAINE HYDROCHLORIDE LACOSAMIDE LAMOTRIGINE ROPIVACAINE HYDROCHLORIDE CARBAMAZEPINE NKTR-171 BENOXINATE HYDROCHLORIDE HEXYLCAINE HYDROCHLORIDE FOSPHENYTOIN MORICIZINE HYDROCHLORIDE

Antibody

HPA072715