Protein detail

SCN7A

Sodium channel protein type 7 subunit alpha (Atypical sodium channel Nav2.1) (Nax channel) (Sodium channel protein type VII subunit alpha)

Entry name SCN7A	UniProt ID Q01118	EVMP confidence score 0.50
Supporting publications (n) 5	Transmembrane count 24	Protein classification FDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Sodium channel protein type 7 subunit alpha (Atypical sodium channel Nav2.1) (Nax channel) (Sodium channel protein type VII subunit alpha)

Protein Class (5)

FDA approved drug targetsMetabolic proteinsPlasma proteinsPredicted intracellular proteinsPredicted membrane proteins

Protein Function (2)

FDA approved drug targets:Small molecule drugs
Predicted intracellular proteins

Transmembrane

118..137; Helical; Name=S1 of repeat I; 142..167; Helical; Name=S2 of repeat I; 179..196; Helical; Name=S3 of repeat I; 201..219; Helical; Name=S4 of repeat I; 238..259; Helical; Name=S5 of repeat I; 368..407; Helical; Name=S6 of repeat I; 506..521; Helical; Name=S1 of repeat II; 531..559; Helical; Name=S2 of repeat II; 569..586; Helical; Name=S3 of repeat II; 593..609; Helical; Name=S4 of repeat II; 627..655; Helical; Name=S5 of repeat II; 702..732; Helical; Name=S6 of repeat II; 935..953; Helical; Name=S1 of repeat III; 962..990; Helical; Name=S2 of repeat III; 999..1020; Helical; Name=S3 of repeat III; 1022..1040; Helical; Name=S4 of repeat III; 1056..1080; Helical; Name=S5 of repeat III; 1168..1202; Helical; Name=S6 of repeat III; 1251..1272; Helical; Name=S1 of repeat IV; 1277..1305; Helical; Name=S2 of repeat IV; 1313..1338; Helical; Name=S3 of repeat IV; 1342..1362; Helical; Name=S4 of repeat IV; 1378..1402; Helical; Name=S5 of repeat IV; 1469..1504; Helical; Name=S6 of repeat IV

Transmembrane Count

Ensembl

ENSG00000136546

Entrez Gene Symbol

SCN7A

Gene Synonym (4)

NaGNav2.1Nav2.2SCN6A

Gene Description

Sodium voltage-gated channel alpha subunit 7

Chromosome

Position

166403573-166611482

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization1

Function & Pathway8

Protein Function (2)

FDA approved drug targets:Small molecule drugs
Predicted intracellular proteins

Cellular Component (3)

Molecular Function (4)

Biological Process (3)

KEGG

hsa04261 Adrenergic signaling in cardiomyocytes

Reactome (6)

Canonical Pathways (3)

M190 Pid tcr jnk pathway
M20 Pid p38 mkk3 6pathway
M257 Pid ephrinb rev pathway

Mediation Categories (2)

Clinical-translation mediationFusion and delivery mediation

Relations & Evidence30

Ligand-Receptor Signaling (29)

29 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
peripheral	peripheral	UniProt_topology	No	No	No	No	No
peripheral	peripheral	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
cell_surface	cell_surface	Surfaceome	No	No	No	No	No
cell_surface	cell_surface	OmniPath	No	No	No	No	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	37588411

Sequence, Structure & Domains13

Sequences

Length

1,682

Mass

193,493

Sequence

MLASPEPKGLVPFTKESFELIKQHIAKTHNEDHEEEDLKPTPDLEVGKKLPFIYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNLPKWRPVLENTLLGIYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQENENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDYPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPKFQQTGKELQEGNETDEAKTIQIEMKKRSPISTDTSLDVLEDATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHPYGYFQVGWNIFDSMIVFHGLIELCLANVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAGQSWCIPFYLMVILIGNLLVLYLFLALVSSFSSCKDVTAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDFLKDKEKSSGTEKNATENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKEKIKQSSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTREELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDPTSGERFPSSEVMNKSRCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVIIDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFKITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDGDRDVHATKEGAYFDKAKEKSPIQSQI

3D Structural Models

Turn

175..177; 217..219; 292..294; 956..960; 1021..1023; 1090..1092; 1098..1100; 1306..1311; 1447..1449

Helix

106..115; 118..135; 144..166; 179..195; 202..210; 211..216; 221..236; 238..259; 262..264; 286..288; 330..332; 341..350; 355..365; 368..370; 371..381; 384..403; 508..523; 532..558; 561..564; 568..584; 596..609; 611..655; 657..659; 674..685; 691..699; 702..732; 922..932; 934..949; 950..953; 962..990; 992..996; 999..1016; 1024..1035; 1036..1040; 1042..1055; 1056..1058; 1059..1080; 1104..1108; 1128..1139; 1144..1151; 1167..1169; 1170..1179; 1182..1203; 1212..1224; 1246..1249; 1251..1268; 1277..1304; 1313..1334; 1344..1350; 1351..1357; 1364..1402; 1420..1431; 1436..1443; 1444..1446; 1469..1502

Beta Strand

170..174; 265..270; 320..324; 585..590; 1086..1088; 1111..1113; 1117..1119; 1156..1159; 1208..1210; 1272..1274; 1358..1362; 1413..1419

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Compositional Bias

804..819; Basic and acidic residues; 820..834; Polar residues

Repeat

100..401; I; 487..758; II; 916..1224; III; 1233..1531; IV

Domain (CC)

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

Region

801..871; Disordered

Protein Families (2)

Sodium channel (TC 1.A.1.10) family
SCN7A subfamily

Sequence Similarities

Belongs to the sodium channel (TC 1.A.1.10) family. SCN7A subfamily.

Clinical Relevance4

Disease Involvement

FDA approved drug targets

Drug Targets

FDA approved drug targets

Drugs (57)

DRONEDARONE HYDROCHLORIDE ORPHENADRINE HYDROCHLORIDE TOCAINIDE HYDROCHLORIDE EVENAMIDE ETHOTOIN MEPIVACAINE HYDROCHLORIDE ETIDOCAINE HYDROCHLORIDE RUFINAMIDE PROPOXYCAINE HYDROCHLORIDE CENOBAMATE DISOPYRAMIDE PHOSPHATE MEPHENYTOIN PROCAINE HYDROCHLORIDE RALFINAMIDE ESLICARBAZEPINE ACETATE CHLOROPROCAINE QUINIDINE SULFATE ZONISAMIDE SAFINAMIDE NERISPIRDINE TETRACAINE PROPAFENONE HYDROCHLORIDE PROPARACAINE HYDROCHLORIDE INDECAINIDE HYDROCHLORIDE RILUZOLE PRILOCAINE PROCAINAMIDE HYDROCHLORIDE TOPIRAMATE PRIMIDONE ESLICARBAZEPINE MERETHOXYLLINE PROCAINE COCAINE HYDROCHLORIDE PRILOCAINE HYDROCHLORIDE PHENYTOIN SODIUM OXCARBAZEPINE LIDOCAINE HYDROCHLORIDE LIDOCAINE IRAMPANEL DICHLOROBENZYL ALCOHOL PHENAZOPYRIDINE HYDROCHLORIDE QUINIDINE GLUCONATE DYCLONINE HYDROCHLORIDE ORPHENADRINE CITRATE QUINIDINE POLYGALACTURONATE MEXILETINE HYDROCHLORIDE ENCAINIDE HYDROCHLORIDE PHENACEMIDE ARTICAINE HYDROCHLORIDE LACOSAMIDE LAMOTRIGINE ROPIVACAINE HYDROCHLORIDE CARBAMAZEPINE NKTR-171 BENOXINATE HYDROCHLORIDE HEXYLCAINE HYDROCHLORIDE FOSPHENYTOIN MORICIZINE HYDROCHLORIDE

Antibody

HPA072715

Supporting Publications5

PMID	Title	Abstract
32795414	Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers.	Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers.
36406491	Automated Proteomics Sample Preparation of Phosphatidylserine-Positive Extracellular Vesicles from Human Body Fluids.	No abstract available
38225453	Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40829696	Mining the plasma proteome: Evaluation of enrichment methods for depth and reproducibility.	No abstract available