Protein detail

ROR2

Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2)

Entry name ROR2	UniProt ID Q01974	EVMP score 0.38
Frequency 7	Transmembrane count 1	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2)

Protein Function

Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Kinases:Tyr protein kinases
Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations

Transmembrane

404..424; Helical

Transmembrane Count

Ensembl

ENSG00000169071

Entrez Gene Symbol

ROR2

Frequency

EVMP Score

0.38

Fluorescence & Localization

Tissue SpecificintestineCell SpecificBreast lactating cells

Function & Pathway

Protein Function

Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
ENZYME proteins:Transferases
Potential drug targets
Enzymes
Kinases:Tyr protein kinases
Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04310 Wnt signaling pathway

Reactome

Canonical Pathways

M209 Pid p38 gamma delta pathway
M69 Pid reelin pathway
M87 Pid lkb1 pathway

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

3 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
ROR2	GSK3B	P49841	S	864	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	ProtMapper:21078818 SIGNOR:21078818
ROR2	APC	P25054	S	864	phosphorylation	SIGNOR	SIGNOR:21078818
ROR2	AXIN1	O15169	S	864	phosphorylation	SIGNOR	SIGNOR:21078818

Ligand-Receptor Signaling

62 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
kinase	receptor	Almen2009	No	Yes	No	Yes	No
cytokine	receptor	Baccin2019	No	Yes	No	Yes	No
receptor_tyrosine_kinases_rtk	receptor	HPMR	No	Yes	No	Yes	No
ror	receptor	HPMR	No	Yes	No	Yes	No
kinase	receptor	Surfaceome	No	Yes	No	Yes	No
wnt_pathway	receptor	ICELLNET	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	HPMR	No	No	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No

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Regulatory Interaction Network

10 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
WNT5A	P41221	ROR2	Q01974	Yes	Yes	No	iTALKICELLNETSIGNORProtMapperSignaLink3HPRD_LRdbtalklrHPRDCui2007Ramilowski2015_Baccin2019WangRamilowski2015CellPhoneDBReactome_LRdbHPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellTalkDBFantom5_LRdbSparser_ProtMapperNetPathconnectomeDB2020SPIKE_LCLRdbSPIKE	ICELLNET:16602827 SIGNOR:26690702 SPIKE_LC:21069266 ProtMapper:22017973 SPIKE_LC:12839624 LRdb:12839624 SPIKE:12839624 SPIKE:20215527 SPIKE_LC:20215527 HPRD:12839624 Baccin2019:12839624 SignaLink3:17203201 SignaLink3:23331499 connectomeDB2020:12839624 Cellinker:18606138 CellTalkDB:12839624 SPIKE:21069266 NetPath:12839624
ROR2	Q01974	FLNA	P21333	Yes	Yes	No	SPIKESPIKE_LCSIGNOR	SPIKE_LC:20359892 SIGNOR:18667433 SPIKE:20359892
ROR2	Q01974	MAGD1	Q9Y5V3	Yes	Yes	No	PhosphoPointHPRDSignaLink3SPIKE_LCSPIKE	HPRD:12754255 SignaLink3:12754255 SPIKE_LC:12754255 SPIKE_LC:16713569 SignaLink3:23331499 SPIKE:12754255 SPIKE:16713569
ROR2	Q01974	BMR1B	O00238	Yes	Yes	No	SignaLink3	SignaLink3:15569154 SignaLink3:23331499
KC1E	P49674	ROR2	Q01974	Yes	Yes	No	SIGNORSignaLink3	SignaLink3:18848778 SIGNOR:15375164 SignaLink3:23331499
ROR2	Q01974	ARBK1	P25098	Yes	Yes	No	SignaLink3	SignaLink3:18848778 SignaLink3:23331499
TAB1	Q15750	ROR2	Q01974	Yes	No	Yes	SIGNOR	SIGNOR:18762249
GSK3B	P49841	ROR2	Q01974	Yes	No	Yes	SIGNOR_ProtMapperiPTMnetSIGNORProtMapper	ProtMapper:21078818 SIGNOR:21078818
ROR2	Q01974	MK08	P45983	Yes	Yes	No	WangSIGNOR	SIGNOR:18667433
	COMPLEX:O15169_P25054_P49841	ROR2	Q01974	Yes	No	Yes	SIGNOR	SIGNOR:21078818

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	ROR2	Q01974	2	PDB	PDB:3zzwPDB:4gt4

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
PRotein Organic Solvent Precipitation；Differential Ultracentrifugation	Mass spectrometry	1	32384937

Sequence, Structure & Domains

Sequences

Length

943

Mass

104,757

Sequence

MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA

3D Structural Models

Turn

262..264; 352..354; 687..689; 692..695

Helix

183..186; 198..216; 221..235; 253..261; 265..273; 275..278; 286..288; 295..297; 307..309; 311..313; 356..358; 368..370; 470..472; 518..530; 561..566; 589..608; 618..620; 625..627; 639..644; 656..658; 661..666; 671..686; 698..706; 719..728; 733..735; 739..747

Beta Strand

174..176; 190..192; 194..197; 279..281; 344..346; 372..381; 385..389; 473..481; 486..492; 502..508; 539..543; 545..548; 550..554; 621..623; 629..631; 648..652

3D Structure

X-ray crystallography (6)

Domain & Motif Annotations

Compositional Bias

765..791; Low complexity; 857..872; Low complexity; 873..883; Polar residues

Domain (FT)

55..145; Ig-like C2-type; 169..303; FZ; 316..394; Kringle; 473..746; Protein kinase

Region

757..796; Disordered; 850..931; Disordered

Protein Families

Protein kinase superfamily
Tyr protein kinase family
ROR subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.

Clinical Relevance

Related Diseases

Metastatic lymph node neoplasm Renal cell carcinoma

Biomarker

Phase 2; Phase 1/2

Drugs

NULL

Interaction Protein

ENSG00000100324ENSG00000120149ENSG00000183283ENSG00000204525

Interaction Count

Interaction Dataset

intact_biogridbiogrid_bioplex