Protein detail
ROR2
Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2)
Entry name ROR2 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 7 | Transmembrane count 1 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2)
Protein Function (7)
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:Tyr protein kinases
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
Transmembrane
404..424; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Supporting publications (n)
7
EVMP confidence score
0.38
Fluorescence & Localization2
Tissue SpecificintestineCell SpecificBreast lactating cells
Function & Pathway8
Protein Function (7)
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- ENZYME proteins:Transferases
- Potential drug targets
- Enzymes
- Kinases:Tyr protein kinases
- Disease related genes
- Human disease related genes:Congenital malformations:Other congenital malformations
Cellular Component (9)
Molecular Function (7)
Biological Process (3)
Reactome (4)
Canonical Pathways (3)
- M209 Pid p38 gamma delta pathway
- M69 Pid reelin pathway
- M87 Pid lkb1 pathway
Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence77
Enzyme-Mediated Modification (3)
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ROR2 | GSK3B | P49841 | S | 864 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | ProtMapper:21078818SIGNOR:21078818 |
| ROR2 | APC | P25054 | S | 864 | phosphorylation | SIGNOR | SIGNOR:21078818 |
| ROR2 | AXIN1 | O15169 | S | 864 | phosphorylation | SIGNOR | SIGNOR:21078818 |
Ligand-Receptor Signaling (62)
62 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| activating_cofactor | receptor_regulator | CellChatDB | Yes | No | No | Yes | No |
| receptor_regulator | receptor_regulator | OmniPath | Yes | No | No | Yes | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| matrix_adhesion | matrix_adhesion | Cellinker | No | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| matrix_adhesion | matrix_adhesion | OmniPath | No | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
Regulatory Interaction Network (10)
10 records.
Protein Complex Composition (1)
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| PRotein Organic Solvent Precipitation；Differential Ultracentrifugation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains12
Sequences
Length
943
Mass
104,757
Sequence
MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA
3D Structural Models
Turn
262..264; 352..354; 687..689; 692..695
Helix
183..186; 198..216; 221..235; 253..261; 265..273; 275..278; 286..288; 295..297; 307..309; 311..313; 356..358; 368..370; 470..472; 518..530; 561..566; 589..608; 618..620; 625..627; 639..644; 656..658; 661..666; 671..686; 698..706; 719..728; 733..735; 739..747
Beta Strand
174..176; 190..192; 194..197; 279..281; 344..346; 372..381; 385..389; 473..481; 486..492; 502..508; 539..543; 545..548; 550..554; 621..623; 629..631; 648..652
3D Structure
X-ray crystallography (6)
Domain & Motif Annotations
Compositional Bias
765..791; Low complexity; 857..872; Low complexity; 873..883; Polar residues
Domain (FT)
55..145; Ig-like C2-type; 169..303; FZ; 316..394; Kringle; 473..746; Protein kinase
Region
757..796; Disordered; 850..931; Disordered
Protein Families (3)
- Protein kinase superfamily
- Tyr protein kinase family
- ROR subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
Clinical Relevance6
Related Diseases (2)
Biomarker
Phase 2; Phase 1/2
Drugs
Interaction Protein (4)
ENSG00000100324ENSG00000120149ENSG00000183283ENSG00000204525
Interaction Count
4
Interaction Dataset (2)
intact_biogridbiogrid_bioplex
Supporting Publications7
| PMID | Title | Abstract |
|---|---|---|
| 30760538 | Microvesicle Proteomic Profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection. | No abstract available |
| 32795414 | Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers. | Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. |
| 33709510 | Unbiased proteomic profiling of host cell extracellular vesicle composition and dynamics upon HIV-1 infection. | No abstract available |
| 38321535 | Identification of specific markers for human pluripotent stem cell-derived small extracellular vesicles. | No abstract available |
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No abstract available |
| 39873726 | Size-Dependent Separation of Extracellular Vesicle Subtypes with Exodisc Enabling Proteomic Analysis in Prostate Cancer. | No abstract available |
| 41201090 | Identification of molecular markers and exploration of the oncogenic role of exomeres in hepatocellular carcinoma. | No abstract available |