Protein detail

P

P protein (Melanocyte-specific transporter protein) (Pink-eyed dilution protein homolog)

Entry name P	UniProt ID Q04671	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 12	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

P protein (Melanocyte-specific transporter protein) (Pink-eyed dilution protein homolog)

Protein Function (4)

Transporters:Electrochemical Potential-driven transporters
Disease related genes
Potential drug targets
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism

Transmembrane

180..197; Helical; 331..347; Helical; 354..370; Helical; 385..401; Helical; 424..440; Helical; 514..530; Helical; 621..637; Helical; 648..664; Helical; 680..696; Helical; 721..737; Helical; 761..777; Helical; 818..834; Helical

Transmembrane Count

Ensembl

ENSG00000104044

Entrez Gene Symbol

OCA2

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway6

Protein Function (4)

Transporters:Electrochemical Potential-driven transporters
Disease related genes
Potential drug targets
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism

Cellular Component (4)

Molecular Function (2)

Biological Process (3)

Reactome (2)

Mediation Categories (2)

Fusion and delivery mediationMetabolism mediation

Relations & Evidence14

Ligand-Receptor Signaling (11)

11 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No

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Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	HLA-DOA HTR3A OCA2	P06340 P46098 Q04671	0:0:0	hu.MAP2
	CHRND FICD OCA2	Q04671 Q07001 Q9BVA6	0:0:0	hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Ultrafiltration / Tangential Flow Filtration	Mass spectrometry [LTQ-FT Ultra]Mass spectrometry	1	39222826

Sequence, Structure & Domains9

Sequences

Length

838

Mass

92,850

Sequence

MHLEGRDGRRYPGAPAVELLQTSVPSGLAELVAGKRRLPRGAGGADPSHSCPRGAAGQSSWAPAGQEFASFLTKGRSHSSLPQMSSSRSKDSCFTENTPLLRNSLQEKGSRCIPVYHPEFITAEESWEDSSADWERRYLLSREVSGLSASASSEKGDLLDSPHIRLRLSKLRRCVQWLKVMGLFAFVVLCSILFSLYPDQGKLWQLLALSPLENYSVNLSSHVDSTLLQVDLAGALVASGPSRPGREEHIVVELTQADALGSRWRRPQQVTHNWTVYLNPRRSEHSVMSRTFEVLTRETVSISIRASLQQTQAVPLLMAHQYLRGSVETQVTIATAILAGVYALIIFEIVHRTLAAMLGSLAALAALAVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIVELKHEIHVWRLTAQRISPASREETAVRRLLLGKVLALEHLLARRLHTFHRQISQEDKNWETNIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVPGIHLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIKMVPEEQRLIAAIVLVVWVSALASSLIDNIPFTATMIPVLLNLSHDPEVGLPAPPLMYALAFGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFRLGFPMMVVSCTVGMCYLLVAHVVVGWN

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q04671-1; Sequence=Displayed; Name=2; IsoId=Q04671-2; Sequence=VSP_012284; Name=3; IsoId=Q04671-3; Sequence=VSP_012285, VSP_012286

Alternative Sequence

349..372; Missing (in isoform 2); 652..668; WIAILGAIWLLILADIH -> GLGLVQAGRYYLSTPES (in isoform 3); 669..838; Missing (in isoform 3)

Domain & Motif Annotations

Compositional Bias

78..87; Polar residues

Region

38..60; Disordered; 74..94; Disordered

Protein Families

CitM (TC 2.A.11) transporter family

Sequence Similarities

Belongs to the CitM (TC 2.A.11) transporter family.

Clinical Relevance1

Drugs (11)

CLEVUDINE ADEFOVIR DIPIVOXIL LB80380 TENOFOVIR ADEFOVIR VALTORCITABINE ENTECAVIR ANHYDROUS TELBIVUDINE LAMIVUDINE PRADEFOVIR MESYLATE ELVUCITABINE

Supporting Publications1

PMID	Title	Abstract
23161513	Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.	Exosomes from mutant KRAS cells contain many tumor-promoting proteins, including KRAS, EGFR, SRC family kinases, and integrins.