Protein detail
P
P protein (Melanocyte-specific transporter protein) (Pink-eyed dilution protein homolog)
Entry name P | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 12 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
P protein (Melanocyte-specific transporter protein) (Pink-eyed dilution protein homolog)
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Potential drug targets
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism
Transmembrane
180..197; Helical; 331..347; Helical; 354..370; Helical; 385..401; Helical; 424..440; Helical; 514..530; Helical; 621..637; Helical; 648..664; Helical; 680..696; Helical; 721..737; Helical; 761..777; Helical; 818..834; Helical
Transmembrane Count
12
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Potential drug targets
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism
Cellular Component
Molecular Function
Biological Process
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
11 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Ultrafiltration / Tangential Flow Filtration | Mass spectrometry [LTQ-FT Ultra]Mass spectrometry | 1 | 39222826 |
Sequence, Structure & Domains
Sequences
Length
838
Mass
92,850
Sequence
MHLEGRDGRRYPGAPAVELLQTSVPSGLAELVAGKRRLPRGAGGADPSHSCPRGAAGQSSWAPAGQEFASFLTKGRSHSSLPQMSSSRSKDSCFTENTPLLRNSLQEKGSRCIPVYHPEFITAEESWEDSSADWERRYLLSREVSGLSASASSEKGDLLDSPHIRLRLSKLRRCVQWLKVMGLFAFVVLCSILFSLYPDQGKLWQLLALSPLENYSVNLSSHVDSTLLQVDLAGALVASGPSRPGREEHIVVELTQADALGSRWRRPQQVTHNWTVYLNPRRSEHSVMSRTFEVLTRETVSISIRASLQQTQAVPLLMAHQYLRGSVETQVTIATAILAGVYALIIFEIVHRTLAAMLGSLAALAALAVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIVELKHEIHVWRLTAQRISPASREETAVRRLLLGKVLALEHLLARRLHTFHRQISQEDKNWETNIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVPGIHLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIKMVPEEQRLIAAIVLVVWVSALASSLIDNIPFTATMIPVLLNLSHDPEVGLPAPPLMYALAFGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFRLGFPMMVVSCTVGMCYLLVAHVVVGWN
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q04671-1; Sequence=Displayed; Name=2; IsoId=Q04671-2; Sequence=VSP_012284; Name=3; IsoId=Q04671-3; Sequence=VSP_012285, VSP_012286
Alternative Sequence
349..372; Missing (in isoform 2); 652..668; WIAILGAIWLLILADIH -> GLGLVQAGRYYLSTPES (in isoform 3); 669..838; Missing (in isoform 3)
3D Structural Models
Domain & Motif Annotations
Compositional Bias
78..87; Polar residues
Region
38..60; Disordered; 74..94; Disordered
Protein Families
CitM (TC 2.A.11) transporter family
Sequence Similarities
Belongs to the CitM (TC 2.A.11) transporter family.