EV MemProt Atlas

Basic Information

Protein Names

Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)

Protein Class

EnzymesPredicted intracellular proteins

Protein Function

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Ensembl

ENSG00000127947

Entrez Gene Symbol

PTPN12

Gene Synonym

PTP-PESTPTPG1

Gene Description

Protein tyrosine phosphatase non-receptor type 12

Chromosome

7

Position

77537295-77640069

Frequency

12

EVMP Score

0.60

Fluorescence & Localization

Function & Pathway

Protein Function

Enzymes
Predicted intracellular proteins
ENZYME proteins:Hydrolases

Cellular Component

Molecular Function

Biological Process

Reactome

Mediation Categories

Adhesion and uptake mediationClinical-translation mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

24 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PTPN12	PRKY	O43930	S	39	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PTPN12	PRKY	O43930	S	435	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PTPN12	PRKCB	P05771	S	39	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA	KEA:17570479
PTPN12	PRKCB	P05771	S	435	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PTPN12	PRKCG	P05129	S	39	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PTPN12	PRKCG	P05129	S	435	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PTPN12	PRKCD	Q05655	S	39	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PTPN12	PRKCD	Q05655	S	435	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PTPN12	PRKCE	Q02156	S	39	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
PTPN12	PRKCE	Q02156	S	435	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP

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Ligand-Receptor Signaling

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network

18 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PTN12	Q05209	FAK2	Q14289	Yes	No	Yes	WangAdhesomeSIGNORProtMapperDEPODHPRDSIGNOR_ProtMapperHPRD-phos	DEPOD:11337490 SIGNOR:11337490 HPRD-phos:12231407 Adhesome:11337490 ProtMapper:11337490 HPRD-phos:11337490 HPRD:15588985 HPRD:11337490 Adhesome:12231407 HPRD:12231407
PTN12	Q05209	ERBB2	P04626	Yes	No	Yes	HINTLit-BM-17SIGNORSPIKE_LC	SPIKE_LC:19167335 HINT:21376233 Lit-BM-17:19167335 SIGNOR:29330094 Lit-BM-17:21376233
PTN12	Q05209	SRC	P12931	Yes	Yes	Yes	Sparser_ProtMapperSIGNORProtMapperDEPODSIGNOR_ProtMapperREACH_ProtMapper	SIGNOR:19350555 SIGNOR:18482983 DEPOD:18482983 ProtMapper:18482983 ProtMapper:19595712 ProtMapper:19350555
CDK2	P24941	PTN12	Q05209	Yes	No	Yes	PhosphoSite_norefSIGNORPhosphoSite_ProtMapperProtMapper	SIGNOR:28842430
PTN12	Q05209	SHC1	P29353	Yes	No	Yes	WangAdhesomeSIGNORProtMapperHPRDHINTIntActSIGNOR_ProtMapperLit-BM-17	Adhesome:20697350 HPRD:11342545 Adhesome:7929214 HINT:24412244 HPRD:12052829 Adhesome:24412244 Lit-BM-17:7929214 HINT:7929214 Lit-BM-17:8626541 ProtMapper:8939605 SIGNOR:8939605 Adhesome:12052829 Lit-BM-17:24189400 Adhesome:11432829 Lit-BM-17:24412244 HINT:27880917 Adhesome:11342545 HPRD:7929214 Lit-BM-17:19380743 HINT:8626541 IntAct:24412244 HINT:33961781 Adhesome:20075861 HPRD:8626541 Adhesome:8626541 HPRD:11432829
PTN12	Q05209	ABL1	P00519	Yes	No	Yes	WangAdhesomeSIGNORProtMapperDEPODHPRDSIGNOR_ProtMapperHPRD-phos	HPRD:11163214 ProtMapper:11163214 HPRD:15588985 Adhesome:11163214 SIGNOR:11163214 DEPOD:11163214 HPRD-phos:11163214
KAPCA	P17612	PTN12	Q05209	Yes	Yes	No	phosphoELM_MIMPAdhesomeMIMPPhosphoSite_MIMPHPRD_MIMPPhosphoSite_norefPhosphoPointiPTMnetProtMapperHPRDPhosphoSite_KEAKEAKinexus_KEAHPRD_KEAWangPhosphoSiteHPRD-phosPhosphoSite_ProtMapper	ProtMapper:18767875 PhosphoSite:7520867 Adhesome:7520867 HPRD:7520867 ProtMapper:7520867 ProtMapper:19651622 ProtMapper:20068231 HPRD-phos:20068231 HPRD-phos:18669648 ProtMapper:18669648 KEA:7520867 KEA:94349924 HPRD-phos:18767875 HPRD-phos:19651622 HPRD-phos:7520867
MK03	P27361	PTN12	Q05209	Yes	No	No	Sparser_ProtMapperiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:21876001 PhosphoSite:21876001

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Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	PTPN12	Q05209	4	PDB	PDB:5j8r

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometryMass spectrometry [MALDI TOF]	1	40326690

Sequence, Structure & Domains

Sequences

Length

780

Mass

88,106

Sequence

MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKDVDVSEDSPPPLPERTPESFVLASEHNTPVRSEWSELQSQERSEQKKSEGLITSENEKCDHPAGGIHYEMCIECPPTFSDKREQISENPTEATDIGFGNRCGKPKGPRDPPSEWT

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q05209-1; Sequence=Displayed; Name=2; IsoId=Q05209-2; Sequence=VSP_046274; Name=3; IsoId=Q05209-3; Sequence=VSP_054168

Alternative Sequence

1..130; Missing (in isoform 2); 1..119; Missing (in isoform 3)

3D Structural Models

Turn

43..46; 111..113; 270..272

Helix

3..17; 27..42; 51..54; 56..61; 71..73; 114..123; 207..219; 236..252; 262..269; 280..298

Beta Strand

74..76; 90..94; 102..106; 128..131; 135..137; 155..157; 160..170; 173..182; 185..194; 222..225; 227..230; 232..235

3D Structure

NMR spectroscopy (1); X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

502..519; Polar residues; 521..533; Basic and acidic residues; 552..577; Polar residues; 587..601; Polar residues; 602..613; Basic and acidic residues; 622..639; Low complexity; 690..703; Polar residues; 704..725; Basic and acidic residues; 771..780; Basic and acidic residues

Domain (FT)

28..293; Tyrosine-protein phosphatase

Region

345..438; Interaction with TGFB1I1; 502..639; Disordered; 657..725; Disordered; 744..780; Disordered

Protein Families

Protein-tyrosine phosphatase family
Non-receptor class 4 subfamily

Sequence Similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.

Clinical Relevance

Drugs

SUNITINIB CHEMBL:CHEMBL601167 CRIZOTINIB

Antibody

HPA007038 HPA007097

Interaction Protein

ENSG00000050820ENSG00000089159ENSG00000111679ENSG00000140368ENSG00000146648ENSG00000160691

Interaction Count

6

Interaction Dataset

intact_biogridintact_biogrid_opencell

Protein symbol PTN12	UniProt ID Q05209	EVMP score 0.60
Frequency 12	Transmembrane count	Protein classification EnzymesPredicted intracellular proteins

PTN12