Protein detail

AMPE

Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (Differentiation antigen gp160) (CD antigen CD249)

Entry name AMPE	UniProt ID Q07075	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification CD markersEnzymesPlasma proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (Differentiation antigen gp160) (CD antigen CD249)

Protein Class (4)

CD markersEnzymesPlasma proteinsPredicted membrane proteins

Protein Function (4)

Peptidases:Metallopeptidases
Enzymes
CD markers
ENZYME proteins:Hydrolases

Transmembrane

19..39; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000138792

Entrez Gene Symbol

ENPEP

Gene Synonym (2)

CD249gp160

Gene Description

Glutamyl aminopeptidase

Chromosome

Position

110365733-110565285

Supporting publications (n)

EVMP confidence score

0.25

Function & Pathway7

Protein Function (4)

Peptidases:Metallopeptidases
Enzymes
CD markers
ENZYME proteins:Hydrolases

Cellular Component (10)

Molecular Function (4)

Biological Process (3)

KEGG

hsa04614 Renin-angiotensin system

Reactome (2)

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationMetabolism mediation

Relations & Evidence26

Ligand-Receptor Signaling (25)

25 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	DGIdb	No	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
cell_surface_enzyme	cell_surface_enzyme	Surfaceome	Yes	No	No	No	No
m1_metallopeptidase	cell_surface_peptidase	OmniPath	Yes	No	No	No	No
cell_surface_enzyme	cell_surface_enzyme	OmniPath	Yes	No	No	No	No
cell_surface_peptidase	cell_surface_peptidase	OmniPath	Yes	No	No	No	No
transmembrane	transmembrane	UniProt_location	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	ELISA	1	26775013

Sequence, Structure & Domains10

Sequences

Length

957

Mass

109,244

Sequence

MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTRQMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG

3D Structural Models

Turn

223..226; 376..378; 401..403; 551..553; 574..577; 679..682; 706..708; 780..782; 842..844

Helix

87..89; 110..112; 164..166; 227..230; 284..286; 313..319; 320..336; 369..371; 381..397; 409..412; 413..430; 432..434; 436..443; 445..451; 467..472; 476..493; 495..508; 516..527; 531..535; 536..538; 621..623; 633..646; 647..649; 652..667; 673..678; 683..685; 689..705; 712..731; 739..754; 758..771; 783..794; 797..809; 813..823; 829..838; 847..849; 850..858; 863..873; 875..882; 887..891; 892..896; 902..914; 919..921; 922..953

Beta Strand

90..92; 97..109; 114..125; 129..135; 138..148; 157..163; 168..177; 181..183; 186..195; 200..210; 213..221; 241..250; 253..259; 261..276; 289..292; 295..300; 306..311; 342..344; 346..353; 355..359; 364..368; 404..408; 512..514; 545..550; 554..559; 581..587; 590..596; 618..620; 625..630

3D Structure

X-ray crystallography (7)

Domain & Motif Annotations

Region

44..83; Disordered

Protein Families

Peptidase M1 family

Sequence Similarities

Belongs to the peptidase M1 family.

Clinical Relevance4

Related Diseases

Hypertension

Biomarker

Phase 2

Drugs (4)

QGC-001 FIRIBASTAT TOSEDOSTAT SGI-1776

Antibody

HPA005128

Supporting Publications1

PMID	Title	Abstract
39120316	A Novel Liquid Biopsy Method Based on Specific Combinations of Vesicular Markers Allows Us to Discriminate Prostate Cancer from Hyperplasia.	Here, we present a novel liquid biopsy method for prostate cancer based on the identification of specific proteins in the extracellular vesicles isolated from the blood of patients with prostate cancer.