Protein detail

AMPE

Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (Differentiation antigen gp160) (CD antigen CD249)

Entry name AMPE	UniProt ID Q07075	EVMP confidence score 0.25
Supporting publications (n) 1	Transmembrane count 1	Protein classification CD markersEnzymesPlasma proteinsPredicted membrane proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (Differentiation antigen gp160) (CD antigen CD249)

Protein Class (4)

CD markersEnzymesPlasma proteinsPredicted membrane proteins

Protein Function (4)

Peptidases:Metallopeptidases
Enzymes
CD markers
ENZYME proteins:Hydrolases

Transmembrane

19..39; Helical; Signal-anchor for type II membrane protein

Transmembrane Count

Ensembl

ENSG00000138792

Entrez Gene Symbol

ENPEP

Gene Synonym (2)

CD249gp160

Gene Description

Glutamyl aminopeptidase

Chromosome

Position

110365733-110565285

Supporting publications (n)

EVMP confidence score

0.25

Function & Pathway7

Protein Function (4)

Peptidases:Metallopeptidases
Enzymes
CD markers
ENZYME proteins:Hydrolases

Cellular Component (10)

Molecular Function (4)

Biological Process (3)

KEGG

hsa04614 Renin-angiotensin system

Reactome (2)

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationMetabolism mediation

Relations & Evidence26

Ligand-Receptor Signaling (25)

25 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_topology	No	No	No	No	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
cell_surface	cell_surface	Surfaceome	No	No	No	No	No

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	ELISA	1	26775013

Sequence, Structure & Domains10

Sequences

Length

957

Mass

109,244

Sequence

MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTRQMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG

3D Structural Models

Turn

223..226; 376..378; 401..403; 551..553; 574..577; 679..682; 706..708; 780..782; 842..844

Helix

87..89; 110..112; 164..166; 227..230; 284..286; 313..319; 320..336; 369..371; 381..397; 409..412; 413..430; 432..434; 436..443; 445..451; 467..472; 476..493; 495..508; 516..527; 531..535; 536..538; 621..623; 633..646; 647..649; 652..667; 673..678; 683..685; 689..705; 712..731; 739..754; 758..771; 783..794; 797..809; 813..823; 829..838; 847..849; 850..858; 863..873; 875..882; 887..891; 892..896; 902..914; 919..921; 922..953

Beta Strand

90..92; 97..109; 114..125; 129..135; 138..148; 157..163; 168..177; 181..183; 186..195; 200..210; 213..221; 241..250; 253..259; 261..276; 289..292; 295..300; 306..311; 342..344; 346..353; 355..359; 364..368; 404..408; 512..514; 545..550; 554..559; 581..587; 590..596; 618..620; 625..630

3D Structure

X-ray crystallography (7)

Domain & Motif Annotations

Region

44..83; Disordered

Protein Families

Peptidase M1 family

Sequence Similarities

Belongs to the peptidase M1 family.

Clinical Relevance4

Related Diseases

Hypertension

Biomarker

Phase 2

Drugs (4)

QGC-001 FIRIBASTAT TOSEDOSTAT SGI-1776

Antibody

HPA005128

Supporting Publications1

PMID	Title	Abstract
39120316	A Novel Liquid Biopsy Method Based on Specific Combinations of Vesicular Markers Allows Us to Discriminate Prostate Cancer from Hyperplasia.	Here, we present a novel liquid biopsy method for prostate cancer based on the identification of specific proteins in the extracellular vesicles isolated from the blood of patients with prostate cancer.