Protein detail
AMPE
Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (Differentiation antigen gp160) (CD antigen CD249)
Protein symbol AMPE | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 1 | Protein classification CD markersEnzymesPlasma proteinsPredicted membrane proteins |
Basic Information
Protein Names
Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (Differentiation antigen gp160) (CD antigen CD249)
Protein Class
CD markersEnzymesPlasma proteinsPredicted membrane proteins
Protein Function
- Peptidases:Metallopeptidases
- Enzymes
- CD markers
- ENZYME proteins:Hydrolases
Transmembrane
19..39; Helical; Signal-anchor for type II membrane protein
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD249gp160
Gene Description
Glutamyl aminopeptidase
Chromosome
4
Position
110365733-110565285
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Function & Pathway
Protein Function
- Peptidases:Metallopeptidases
- Enzymes
- CD markers
- ENZYME proteins:Hydrolases
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
25 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_surface | cell_surface | OmniPath | No | No | No | No | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | No | No |
| transmembrane_phobius | transmembrane_predicted | Almen2009 | No | No | No | No | No |
| transmembrane_sosui | transmembrane_predicted | Almen2009 | No | No | No | No | No |
| transmembrane_tmhmm | transmembrane_predicted | Almen2009 | No | No | No | No | No |
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Regulatory Interaction Network
0 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | ELISA | 1 | 26775013 |
Sequence, Structure & Domains
Sequences
Length
957
Mass
109,244
Sequence
MNFAEREGSKRYCIQTKHVAILCAVVVGVGLIVGLAVGLTRSCDSSGDGGPGTAPAPSHLPSSTASPSGPPAQDQDICPASEDESGQWKNFRLPDFVNPVHYDLHVKPLLEEDTYTGTVSISINLSAPTRYLWLHLRETRITRLPELKRPSGDQVQVRRCFEYKKQEYVVVEAEEELTPSSGDGLYLLTMEFAGWLNGSLVGFYRTTYTENGQVKSIVATDHEPTDARKSFPCFDEPNKKATYTISITHPKEYGALSNMPVAKEESVDDKWTRTTFEKSVPMSTYLVCFAVHQFDSVKRISNSGKPLTIYVQPEQKHTAEYAANITKSVFDYFEEYFAMNYSLPKLDKIAIPDFGTGAMENWGLITYRETNLLYDPKESASSNQQRVATVVAHELVHQWFGNIVTMDWWEDLWLNEGFASFFEFLGVNHAETDWQMRDQMLLEDVLPVQEDDSLMSSHPIIVTVTTPDEITSVFDGISYSKGSSILRMLEDWIKPENFQKGCQMYLEKYQFKNAKTSDFWAALEEASRLPVKEVMDTWTRQMGYPVLNVNGVKNITQKRFLLDPRANPSQPPSDLGYTWNIPVKWTEDNITSSVLFNRSEKEGITLNSSNPSGNAFLKINPDHIGFYRVNYEVATWDSIATALSLNHKTFSSADRASLIDDAFALARAQLLDYKVALNLTKYLKREENFLPWQRVISAVTYIISMFEDDKELYPMIEEYFQGQVKPIADSLGWNDAGDHVTKLLRSSVLGFACKMGDREALNNASSLFEQWLNGTVSLPVNLRLLVYRYGMQNSGNEISWNYTLEQYQKTSLAQEKEKLLYGLASVKNVTLLSRYLDLLKDTNLIKTQDVFTVIRYISYNSYGKNMAWNWIQLNWDYLVNRYTLNNRNLGRIVTIAEPFNTELQLWQMESFFAKYPQAGAGEKPREQVLETVKNNIEWLKQHRNTIREWFFNLLESG
3D Structural Models
Turn
223..226; 376..378; 401..403; 551..553; 574..577; 679..682; 706..708; 780..782; 842..844
Helix
87..89; 110..112; 164..166; 227..230; 284..286; 313..319; 320..336; 369..371; 381..397; 409..412; 413..430; 432..434; 436..443; 445..451; 467..472; 476..493; 495..508; 516..527; 531..535; 536..538; 621..623; 633..646; 647..649; 652..667; 673..678; 683..685; 689..705; 712..731; 739..754; 758..771; 783..794; 797..809; 813..823; 829..838; 847..849; 850..858; 863..873; 875..882; 887..891; 892..896; 902..914; 919..921; 922..953
Beta Strand
90..92; 97..109; 114..125; 129..135; 138..148; 157..163; 168..177; 181..183; 186..195; 200..210; 213..221; 241..250; 253..259; 261..276; 289..292; 295..300; 306..311; 342..344; 346..353; 355..359; 364..368; 404..408; 512..514; 545..550; 554..559; 581..587; 590..596; 618..620; 625..630
3D Structure
X-ray crystallography (7)
Domain & Motif Annotations
Region
44..83; Disordered
Protein Families
Peptidase M1 family
Sequence Similarities
Belongs to the peptidase M1 family.
Clinical Relevance
Related Diseases
Biomarker
Phase 2
Antibody