EV MemProt Atlas

Basic Information11

Protein Names

Kinesin light chain 1 (KLC 1)

Protein Class

Predicted intracellular proteins

Protein Function

Predicted intracellular proteins

Ensembl

ENSG00000126214

Entrez Gene Symbol

KLC1

Gene Synonym (10)

hKLC1BhKLC1GhKLC1JhKLC1NhKLC1PhKLC1RhKLC1SKLCKNS2KNS2A

Gene Description

Kinesin light chain 1

Chromosome

14

Position

103561896-103714249

Supporting publications (n)

18

EVMP confidence score

0.60

Fluorescence & Localization5

Tissue Specificheart muscleCell SpecificExtravillous trophoblastsSingle-Nuclei Brain Specificendothelial cellBlood Cell Specificclassical monocyteBlood Lineage Specificdendritic cells

Function & Pathway6

Protein Function

Predicted intracellular proteins

Cellular Component (7)

Molecular Function (3)

KEGG (8)

Reactome (15)

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Mediation Categories (4)

Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence30

Enzyme-Mediated Modification (7)

7 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
KLC1	PRKAB1	Q9Y478	S	521	phosphorylation	dbPTM	dbPTM:18669648 dbPTM:20074060
KLC1	PRKAB1	Q9Y478	S	524	phosphorylation	dbPTM	dbPTM:18669648 dbPTM:20074060
KLC1	PRKAA2	P54646	S	521	phosphorylation	dbPTM	dbPTM:18669648 dbPTM:20074060
KLC1	PRKAA2	P54646	S	524	phosphorylation	dbPTM	dbPTM:18669648 dbPTM:20074060
KLC1	MAPK3	P27361	S	460	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	SIGNOR:21385839 ProtMapper:21385839
KLC1	MAPK1	P28482	S	460	phosphorylation	SIGNOR_ProtMapperSIGNORProtMapper	SIGNOR:21385839 ProtMapper:21385839
KLC1	PRKAA1	Q13131	S	521	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper

Ligand-Receptor Signaling (5)

5 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Regulatory Interaction Network (4)

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MK03	P27361	KLC1	Q07866	Yes	No	Yes	SIGNOR_ProtMapperiPTMnetSIGNORProtMapper	SIGNOR:21385839 ProtMapper:21385839
KLC1	Q07866	TOR1A	O14656	Yes	Yes	No	SIGNOR	SIGNOR:14970196
MK01	P28482	KLC1	Q07866	Yes	No	Yes	SIGNOR_ProtMapperiPTMnetSIGNORProtMapper	SIGNOR:21385839 ProtMapper:21385839
AAPK1	Q13131	KLC1	Q07866	Yes	No	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:20074060

Protein Complex Composition (13)

13 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_SC_Cluster366	COA8 GIT1 KLC1	Q07866 Q96IL0 Q9Y2X7	1:1:1	Compleat	Compleat:HC3147
KLC1-nKHC-uKHC kinesin complex	COA8 KIF5A KIF5B KIF5C KLC1	O60282 P33176 Q07866 Q12840 Q96IL0	1:1:1:1:1	Compleat	Compleat:HC2971	9624122
RAB27A-SLP3-KLC1 transport complex	KLC1 RAB27A SYTL3	P51159 Q07866 Q4VX76	0:0:0	CORUM	CORUM:6307	22308290
polarisome complex	COA8 GIT1 KLC1 PRPF40A	O75400 Q07866 Q96IL0 Q9Y2X7	1:1:1:1	Compleat	Compleat:HC3614	9632790
	ARHGAP29 CDC42 DIAPH2 GIT1 KLC1 MAPK8IP3 RHOD TBC1D3F	A6NER0 O00212 O60879 P60953 Q07866 Q52LW3 Q9UPT6 Q9Y2X7	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6831
	CDC42 DIAPH2 GIT1 GRTP1 KLC1 PAK3 TBC1D3F	A6NER0 O60879 O75914 P60953 Q07866 Q5TC63 Q9Y2X7	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4101
	CDC42 DIAPH2 GIT1 KLC1 PAK3 SGSM3 TBC1D3F	A6NER0 O60879 O75914 P60953 Q07866 Q96HU1 Q9Y2X7	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6503
	KIF2A KIF5A KIF5B KIF5C KLC1 RHOT1 UBC	O00139 O60282 P0CG48 P33176 Q07866 Q12840 Q8IXI2	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7644
	ARHGAP27 CDC42 DIAPH2 GIT1 KLC1 PAK3 TBC1D10B UBC	O60879 O75914 P0CG48 P60953 Q07866 Q4KMP7 Q6ZUM4 Q9Y2X7	1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8592
	CDC42 FHOD1 GIT1 KLC1 PAK3 SGSM3 USP6NL	O75914 P60953 Q07866 Q92738 Q96HU1 Q9Y2X7 Q9Y613	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8670

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	38071653

Sequence, Structure & Domains15

Sequences

Length

573

Mass

65,310

Sequence

MYDNMSTMVYIKEDKLEKLTQDEIISKTKQVIQGLEALKNEHNSILQSLLETLKCLKKDDESNLVEEKSNMIRKSLEMLELGLSEAQVMMALSNHLNAVESEKQKLRAQVRRLCQENQWLRDELANTQQKLQKSEQSVAQLEEEKKHLEFMNQLKKYDDDISPSEDKDTDSTKEPLDDLFPNDEDDPGQGIQQQHSSAAAAAQQGGYEIPARLRTLHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKDAANLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEYYYQRALEIYQTKLGPDDPNVAKTKNNLASCYLKQGKFKQAETLYKEILTRAHEREFGSVDDENKPIWMHAEEREECKGKQKDGTSFGEYGGWYKACKVDSPTVTTTLKNLGALYRRQGKFEAAETLEEAAMRSRKQGLDNVHKQRVAEVLNDPENMEKRRSRESLNVDVVKYESGPDGGEEVSMSVEWNGGVSGRASFCGKRQQQQWPGRRHR

Alternative Products

Event=Alternative splicing; Named isoforms=10; Comment=Additional isoforms seem to exist. Has the potential to produce 285'919 splice forms.; Name=A; IsoId=Q07866-1; Sequence=Displayed; Name=C; Synonyms=KLC1C, R, KLC1R; IsoId=Q07866-2; Sequence=VSP_008018; Name=G; Synonyms=KLC1G; IsoId=Q07866-3; Sequence=VSP_008017; Name=J; Synonyms=KLC1J; IsoId=Q07866-4; Sequence=VSP_008019, VSP_008020; Name=K; Synonyms=KLC1K; IsoId=Q07866-5; Sequence=VSP_008019; Name=N; Synonyms=KLC1N; IsoId=Q07866-6; Sequence=VSP_008017, VSP_008019, VSP_008020; Name=P; Synonyms=KLC1P; IsoId=Q07866-7; Sequence=VSP_008021; Name=S; Synonyms=KLC1S, Q, KLC1Q; IsoId=Q07866-8; Sequence=VSP_008017, VSP_008018; Name=I; IsoId=Q07866-9; Sequence=VSP_023323; Name=D; Synonyms=KLC1D; IsoId=Q07866-10; Sequence=VSP_046424

Alternative Sequence

542..573; VSMSVEWNGGVSGRASFCGKRQQQQWPGRRHR -> MKRASSLNVLNVGGKAAEDRFQERNNCLADSRALSASHTDLAH (in isoform P); 542..550; Missing (in isoform G, isoform N and isoform S); 550; G -> GDGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPGMKRASSLNVLNVGGKAAEDRFQ (in isoform I); 551..573; GVSGRASFCGKRQQQQWPGRRHR -> MRKMKLGLVN (in isoform C and isoform S); 551..573; GVSGRASFCGKRQQQQWPGRRHR -> DGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPGASLAEPLFVENDSSSSGLEDATAN (in isoform D); 551; G -> DGTGSLKRSGSFSKLRASIRRSSEKLVRKLKGGSSRESEPKNPG (in isoform J, isoform K and isoform N); 552..573; VSGRASFCGKRQQQQWPGRRHR -> MKRASSLNVLNVGGKAAEDRFQERNNCLADSRALSASHTDLAH (in isoform J and isoform N)

3D Structural Models

Turn

351..353

Helix

211..225; 229..247; 252..267; 271..289; 294..309; 313..331; 336..350; 355..372; 378..394; 397..415; 426..435; 463..477; 480..494

Beta Strand

203..205; 249..251

3D Structure

X-ray crystallography (4)

Domain & Motif Annotations

Compositional Bias

155..176; Basic and acidic residues; 188..203; Low complexity

Repeat

213..246; TPR 1; 255..288; TPR 2; 297..330; TPR 3; 339..372; TPR 4; 381..414; TPR 5; 464..497; TPR 6

Coiled Coil

27..156

Region

155..203; Disordered; 553..573; Disordered

Protein Families

Kinesin light chain family

Sequence Similarities

Belongs to the kinesin light chain family.

Clinical Relevance5

Drugs (3)

FLUOROURACIL IRINOTECAN HYDROCHLORIDE LEUCOVORIN CALCIUM

Antibody (3)

CAB009798 HPA044617 HPA052450

Interaction Protein (9)

ENSG00000108953ENSG00000128245ENSG00000134308ENSG00000137171ENSG00000164924ENSG00000166913ENSG00000170027ENSG00000170759ENSG00000174996

Interaction Count

9

Interaction Dataset (2)

biogrid_opencellintact_biogrid_opencell

Supporting Publications18

PMID	Title	Abstract
26826536	[Cardiovascular risk study in patients with renin-angiotensin system blockade by means of the proteone of circulating extracellular vesicles].	No abstract available
30915084	Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton.	No abstract available
31805958	Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.	No abstract available
32560723	T2 and T17 cytokines alter the cargo and function of airway epithelium-derived extracellular vesicles.	No abstract available
33592500	A Proteomic Approach to Understand the Clinical Significance of Acute Myeloid Leukemia-Derived Extracellular Vesicles Reflecting Essential Characteristics of Leukemia.	No abstract available
34064677	Ubiquinone Metabolism and Transcription HIF-1 Targets Pathway Are Toxicity Signature Pathways Present in Extracellular Vesicles of Paraquat-Exposed Human Brain Microvascular Endothelial Cells.	No abstract available
36064647	Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells.	No abstract available
36146834	Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.	No abstract available
36686464	Extracellular vesicles of human diabetic retinopathy retinal tissue and urine of diabetic retinopathy patients are enriched for the junction plakoglo bin protein.	No abstract available
37322475	Comprehensive profiling of extracellular vesicles in uveitis and scleritis enables biomarker discovery and mechanism exploration.	No abstract available

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Entry name KLC1	UniProt ID Q07866	EVMP confidence score 0.60
Supporting publications (n) 18	Transmembrane count	Protein classification Predicted intracellular proteins